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IPR008962 is a PapD-like superfamily.
<p>The PapD-like superfamily of periplasmic chaperones directs the assembly of over 30 diverse adhesive surface organelles that mediate the attachment of many different pathogenic bacteria to host tissues, a critical early step in the development of disease. PapD, the prototypical chaperone, is necessary for the assembly of P pili. P pili contain the adhesin PapG, which mediates the attachment of uropathogenic Escherichia coli to Gal(alpha) Gal receptors present on kidney cells and are critical for the initiation of pyelonephritis. The PapD-like chaperones consist of two Ig-like domains oriented toward each other, forming L-shaped molecules. In the chaperone-subunit complex, the G1beta strand of the chaperone completes an atypical Ig fold in the subunit by occupying the groove and running parallel to the subunit C-terminal F strand. This donor strand complementation interaction simultaneously stabilises pilus subunits and caps their interactive surfaces, preventing their premature oligomerisation in the periplasm. During pilus biogenesis, the highly conserved N-terminal extension of one subunit has been proposed to displace the chaperone G1beta strand from its neighbouring subunit in a mechanism termed donor strand exchange [[cite:PUB00010640]].</p> <p>This entry represents the immunoglobulin (Ig)-like β-sandwich domain found in PapD, as well as in other periplasmic chaperone proteins that include FimC and SfaE from E. coli, and Caf1m from Yersinia pestis [[cite:PUB00016285]]. In addition, major sperm proteins (MSP) and other related sperm proteins (such as WR4 and SSP-19) contain an Ig-like domain with a similar structural fold to PapD [[cite:PUB00016286], [cite:PUB00016287]]. Major sperm proteins are central components in molecular interactions underlying sperm motility, with many isoforms existing in Caenorhabditis elegans.</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Hermes [Medicago truncatula] gi|261824308|gb|ACX94227.1| | 18 | ||
| – | PREDICTED: ankyrin repeat and protein kinase domain-containing protein 1-like [Fragaria vesca subsp]. vesca] gi|470103946|ref|XP_004288386.1| | 18 | ||
| – | PREDICTED: vesicle-associated protein 2-1-like [Cicer arietinum] gi|502160402|ref|XP_004511733.1| | 15 | ||
| – | PREDICTED: vesicle-associated protein 2-1-like [Cicer arietinum] gi|502160402|ref|XP_004511733.1| | 14 | ||
| – | PREDICTED: vesicle-associated protein 1-2-like [Glycine max] gi|356495613|ref|XP_003516669.1| | 16 | ||
| – | Disease resistance-like protein GS0-1 [Medicago truncatula] gi|357494437|ref|XP_003617507.1| | 15 | ||
| – | PREDICTED: vesicle-associated protein 1-1-like [Fragaria vesca subsp]. vesca] gi|470126951|ref|XP_004299443.1| | 9 | ||
| – | PREDICTED: vesicle-associated protein 1-2-like [Glycine max] gi|356495613|ref|XP_003516669.1| | 14 | ||
| – | PREDICTED: ankyrin-2-like [Cicer arietinum] gi|502097529|ref|XP_004491016.1| | 18 | ||
| – | PREDICTED: vesicle-associated protein 1-2-like [Glycine max] gi|356496332|ref|XP_003517022.1| | 11 | ||
| – | PREDICTED: vesicle-associated protein 1-2-like [Glycine max] gi|356496332|ref|XP_003517022.1| | 15 | ||
| – | PREDICTED: vesicle-associated protein 4-2-like [Glycine max] gi|356543790|ref|XP_003540343.1| | 10 | ||
| – | PREDICTED: vesicle-associated protein 4-2-like [Glycine max] gi|356517568|ref|XP_003527459.1| | 10 | ||
| – | Vesicle-associated membrane protein-associated protein A [Medicago truncatula] gi|357475961|ref|XP_003608266.1| | 10 | ||
| – | Vesicle-associated membrane protein-associated protein SCS2 [Medicago truncatula] gi|357478585|ref|XP_003609578.1| | 11 | ||
| – | Vesicle-associated membrane protein-associated protein SCS2 [Medicago truncatula] gi|357478585|ref|XP_003609578.1| | 11 | ||
| – | PREDICTED: vesicle-associated protein 2-2-like [Glycine max] gi|356574914|ref|XP_003555588.1| | 12 | ||
| – | PREDICTED: vesicle-associated protein 2-2-like [Glycine max] gi|356574914|ref|XP_003555588.1| | 10 | ||
| – | PREDICTED: ankyrin-2-like [Cicer arietinum] gi|502118004|ref|XP_004496053.1| | 17 | ||
| – | Ankyrin repeat-containing protein, putative; TAIR: AT2G03430.1 Ankyrin repeat family protein; Swiss-Prot: sp|Q08DV6|ASB3_BOVIN Ankyrin repeat and SOCS box protein 3; TrEMBL-Plants: tr|I1JIE8|I1JIE8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0074700 | 19 | ||
| – | Ankyrin repeat-containing protein; TAIR: AT5G13530.1 protein kinases;ubiquitin-protein ligase; Swiss-Prot: sp|Q9ULJ7|ANR50_HUMAN Ankyrin repeat domain-containing protein 50; TrEMBL-Plants: tr|A0A1J7G1T5|A0A1J7G1T5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0646300 | 21 | ||
| – | Ankyrin repeat-containing protein; TAIR: AT5G14230.1 ankyrin; Swiss-Prot: sp|Q01484|ANK2_HUMAN Ankyrin-2; TrEMBL-Plants: tr|D3J162|D3J162_MEDTR Ankyrin repeat RF-like protein, putative; Found in the gene: LotjaGi2g1v0091200 | 19 | ||
| – | Vesicle-associated protein 1-1; TAIR: AT5G47180.1 Plant VAMP (vesicle-associated membrane protein) family protein; Swiss-Prot: sp|Q9LVU1|VAP21_ARATH Vesicle-associated protein 2-1; TrEMBL-Plants: tr|I3SMW1|I3SMW1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0419800 | 16 | ||
| – | Vesicle-associated protein 1-1; TAIR: AT5G47180.1 Plant VAMP (vesicle-associated membrane protein) family protein; Swiss-Prot: sp|Q9LVU1|VAP21_ARATH Vesicle-associated protein 2-1; TrEMBL-Plants: tr|I3SMW1|I3SMW1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0419800 | 17 | ||
| – | Vesicle-associated 1-1-like protein; TAIR: AT2G45140.1 plant VAP homolog 12; Swiss-Prot: sp|Q9SHC8|VAP12_ARATH Vesicle-associated protein 1-2; TrEMBL-Plants: tr|I3S2M8|I3S2M8_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0424200 | 17 | ||
| – | Vesicle-associated 1-1-like protein; TAIR: AT2G45140.1 plant VAP homolog 12; Swiss-Prot: sp|Q9SHC8|VAP12_ARATH Vesicle-associated protein 1-2; TrEMBL-Plants: tr|I3SEQ0|I3SEQ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0424300 | 17 | ||
| – | Vesicle-associated 1-1-like protein; TAIR: AT2G45140.1 plant VAP homolog 12; Swiss-Prot: sp|Q9SHC8|VAP12_ARATH Vesicle-associated protein 1-2; TrEMBL-Plants: tr|I3SEQ0|I3SEQ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0424300 | 15 | ||
| – | Vesicle-associated 1-1-like protein; TAIR: AT2G45140.1 plant VAP homolog 12; Swiss-Prot: sp|Q9SHC8|VAP12_ARATH Vesicle-associated protein 1-2; TrEMBL-Plants: tr|I3SEQ0|I3SEQ0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0424300 | 17 | ||
| – | Vesicle-associated 1-1-like protein; TAIR: AT2G45140.1 plant VAP homolog 12; Swiss-Prot: sp|Q9SHC8|VAP12_ARATH Vesicle-associated protein 1-2; TrEMBL-Plants: tr|K7K3P5|K7K3P5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0206300 | 16 | ||
| – | Vesicle-associated protein 4-2; TAIR: AT4G21450.1 PapD-like superfamily protein; Swiss-Prot: sp|Q8VYN2|VAP42_ARATH Vesicle-associated protein 4-2; TrEMBL-Plants: tr|I3SHF4|I3SHF4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0439800 | 11 | ||
| – | Vesicle-associated protein 4-2; TAIR: AT4G21450.1 PapD-like superfamily protein; Swiss-Prot: sp|Q8VYN2|VAP42_ARATH Vesicle-associated protein 4-2; TrEMBL-Plants: tr|I3T8Y7|I3T8Y7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0459500 | 11 | ||
| – | Vesicle-associated protein 4-2; TAIR: AT4G21450.1 PapD-like superfamily protein; Swiss-Prot: sp|Q8VYN2|VAP42_ARATH Vesicle-associated protein 4-2; TrEMBL-Plants: tr|I3T8Y7|I3T8Y7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0459500 | 11 | ||
| – | Vesicle-associated protein 4-2; TAIR: AT4G21450.1 PapD-like superfamily protein; Swiss-Prot: sp|Q8VYN2|VAP42_ARATH Vesicle-associated protein 4-2; TrEMBL-Plants: tr|I3T8Y7|I3T8Y7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0459500 | 11 | ||
| – | Vesicle-associated protein 4-2; TAIR: AT4G21450.1 PapD-like superfamily protein; Swiss-Prot: sp|Q8VYN2|VAP42_ARATH Vesicle-associated protein 4-2; TrEMBL-Plants: tr|Q2HTV7|Q2HTV7_MEDTR Major sperm protein; Found in the gene: LotjaGi4g1v0048100 | 11 | ||
| – | Vesicle-associated protein 4-2; TAIR: AT4G21450.1 PapD-like superfamily protein; Swiss-Prot: sp|Q8VYN2|VAP42_ARATH Vesicle-associated protein 4-2; TrEMBL-Plants: tr|Q2HTV7|Q2HTV7_MEDTR Major sperm protein; Found in the gene: LotjaGi4g1v0048100 | 11 | ||
| – | Vesicle-associated protein 1-2; TAIR: AT1G08820.1 vamp/synaptobrevin-associated protein 27-2; Swiss-Prot: sp|B9DHD7|VAP22_ARATH Vesicle-associated protein 2-2; TrEMBL-Plants: tr|C6THF6|C6THF6_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi4g1v0346700 | 16 | ||
| – | Vesicle-associated protein 1-2; TAIR: AT1G08820.1 vamp/synaptobrevin-associated protein 27-2; Swiss-Prot: sp|B9DHD7|VAP22_ARATH Vesicle-associated protein 2-2; TrEMBL-Plants: tr|A0A0R0EF48|A0A0R0EF48_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0217200 | 16 | ||
| – | Ankyrin repeat-containing protein, putative; TAIR: AT5G20350.1 Ankyrin repeat family protein with DHHC zinc finger domain-containing protein; Swiss-Prot: sp|Q01484|ANK2_HUMAN Ankyrin-2; TrEMBL-Plants: tr|D3J163|D3J163_MEDTR Ankyrin repeat, PH and SEC7 domain secG-like protein; Found in the gene: LotjaGi5g1v0260800 | 18 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF49354 | SUPERFAMILY | 1 | 2.63 |