Description

IPR000535 is a Major sperm protein (MSP) domain.

<p>Nematode sperm are unusual amoeboid cells in which motility is not based on actin, but instead on the major sperm protein (MSP). MSP is a dimeric molecule that polymerises to form non-polar filaments constructed from two helical subfilaments that wind round one another. The filaments then assemble into larger macromolecular assemblies called fibre complexes. MSP is a small (~14kDa) basic protein typically encoded by a multigene family of up to 28 members [[cite:PUB00003372], [cite:PUB00016286], [cite:PUB00018203], [cite:PUB00018204]]. An about 120-amino acid domain similar to MSP has been found in other proteins, including: </p> <ul> <li>Animal Vesicle-Associated Membrane Protein-associated (VAMP-associated) protein family of 33kDa (VAP33). VAP33 is required for neurotransmitter release. It binds to the v-SNARE synaptobrevin/VAMP which is associated with vesicle fusion. VAP33 has a two-domain structure with its N terminus being highly homologous to MSP, whereas its C terminus is based on a putative α-helical coiled-coil combined with an extremely hydrophobic membrane-attachment region [[cite:PUB00018205]].</li> <li>Nicotiana plumbaginifolia VAP27, a VAP33 homologue. It interacts with the resistance protein Cf9 [[cite:PUB00018206]].</li> <li>Yeast inositol regulator SCS2, a VAP33 homologue. It is C-terminally anchored to the endoplasmic reticulum [[cite:PUB00018207]].</li> </ul> <p>The MSP polypeptide chain has an immunoglobulin-like fold based on a seven-stranded β sandwich measuring approximately 15 A x 20 A x 45 A and having opposing three-stranded and four-stranded β sheets [[cite:PUB00003372]].</p> <p>This entry represents the MSP domain.</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 40

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: