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IPR017921 is a Zinc finger, CTCHY-type.
<p>Zinc finger (Znf) domains are relatively small protein motifs which contain multiple finger-like protrusions that make tandem contacts with their target molecule. Some of these domains bind zinc, but many do not; instead binding other metals such as iron, or no metal at all. For example, some family members form salt bridges to stabilise the finger-like folds. They were first identified as a DNA-binding motif in transcription factor TFIIIA from Xenopus laevis (African clawed frog), however they are now recognised to bind DNA, RNA, protein and/or lipid substrates [[cite:PUB00035807], [cite:PUB00035805], [cite:PUB00035806], [cite:PUB00035804], [cite:PUB00014077]]. Their binding properties depend on the amino acid sequence of the finger domains and of the linker between fingers, as well as on the higher-order structures and the number of fingers. Znf domains are often found in clusters, where fingers can have different binding specificities. There are many superfamilies of Znf motifs, varying in both sequence and structure. They display considerable versatility in binding modes, even between members of the same class (e.g. some bind DNA, others protein), suggesting that Znf motifs are stable scaffolds that have evolved specialised functions. For example, Znf-containing proteins function in gene transcription, translation, mRNA trafficking, cytoskeleton organisation, epithelial development, cell adhesion, protein folding, chromatin remodelling and zinc sensing, to name but a few [[cite:PUB00035812]]. Zinc-binding motifs are stable structures, and they rarely undergo conformational changes upon binding their target.</p> <p>Pirh2 is an eukaryotic ubiquitin protein ligase, which has been shown to promote p53 degradation in mammals. Pirh2 physically interacts with p53 and promotes ubiquitination of p53 independently of MDM2. Like MDM2, Pirh2 is thought to participate in an autoregulatory feedback loop that controls p53 function. Pirh2 proteins contain three distinct zinc fingers, the CHY-type, the CTCHY-type which is C-terminal to the CHY-type zinc finger and a RING finger. The CHY-type zinc finger has no known functions but the region encompassing the CTCHY-type zinc finger is required for binding to p53 in mammals [[cite:PUB00043738]].</p> <p>The CTCHY-type zinc finger has so far only been found in Pirh2 proteins. It binds 3 zinc atoms as shown in the following schematic representation:</p> <pre> The CTCHY-type zinc finger: +--+------------+------+ | | | | CxxCxxxxxxxxxxHCxxCxxCxxxxxxxxxHCxxCxxCxxxxxxxxHxC | | | | | | | | +--+----------+------+ +--+-----------+-+ 'C': conserved cysteine involved in the binding of one zinc atom. 'H': conserved histidine involved in the binding of one zinc atom. </pre>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Zinc finger protein-related isoform 1 [Theobroma cacao] gi|508708206|gb|EOY00103.1| | 21 | ||
– | Zinc finger protein-related isoform 1 [Theobroma cacao] gi|508708206|gb|EOY00103.1| | 24 | ||
– | PREDICTED: RING finger and CHY zinc finger domain-containing protein 1-like [Glycine max] gi|356515508|ref|XP_003526442.1| | 10 | ||
– | PREDICTED: RING finger and CHY zinc finger domain-containing protein 1-like [Glycine max] gi|356555553|ref|XP_003546095.1| | 21 | ||
– | PREDICTED: RING finger and CHY zinc finger domain-containing protein 1-like [Glycine max] gi|356505514|ref|XP_003521535.1| | 20 | ||
– | Zinc finger protein-like protein [Medicago truncatula] gi|357500299|ref|XP_003620438.1| | 24 | ||
– | PREDICTED: RING finger and CHY zinc finger domain-containing protein 1-like [Glycine max] gi|356539356|ref|XP_003538164.1| | 22 | ||
– | RING finger and CHY zinc finger domain-containing protein [Medicago truncatula] gi|357504223|ref|XP_003622400.1| | 24 | ||
– | Zinc finger protein-like protein [Medicago truncatula] gi|357500299|ref|XP_003620438.1| | 24 | ||
– | Zinc finger protein-like protein [Medicago truncatula] gi|357500299|ref|XP_003620438.1| | 24 | ||
– | RING finger and CHY zinc finger domain-containing protein [Medicago truncatula] gi|357447417|ref|XP_003593984.1| | 20 | ||
– | RING finger and CHY zinc finger protein; TAIR: AT5G25560.1 CHY-type/CTCHY-type/RING-type Zinc finger protein; Swiss-Prot: sp|Q8VZK0|MIEL1_ARATH E3 ubiquitin-protein ligase MIEL1; TrEMBL-Plants: tr|I1K915|I1K915_SOYBN C2H2-Zn transcription factor; Found in the gene: LotjaGi1g1v0390600 | 22 | ||
– | RING finger and CHY zinc finger protein; TAIR: AT5G18650.1 CHY-type/CTCHY-type/RING-type Zinc finger protein; Swiss-Prot: sp|Q8VZK0|MIEL1_ARATH E3 ubiquitin-protein ligase MIEL1; TrEMBL-Plants: tr|S5U437|S5U437_MAIZE Uncharacterized protein; Found in the gene: LotjaGi1g1v0561900 | 21 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|I1KIY9|I1KIY9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0205100 | 26 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|I1KIZ0|I1KIZ0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0205100 | 19 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|I1KIY9|I1KIY9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0205100 | 21 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|I1KIY9|I1KIY9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0205100 | 26 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|I1KIY9|I1KIY9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0205100 | 26 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|I1L2P4|I1L2P4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0274900 | 27 | ||
– | RING finger and CHY zinc finger protein; TAIR: AT5G22920.1 CHY-type/CTCHY-type/RING-type Zinc finger protein; Swiss-Prot: sp|Q8VZK0|MIEL1_ARATH E3 ubiquitin-protein ligase MIEL1; TrEMBL-Plants: tr|I3SWI0|I3SWI0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0484900 | 23 | ||
– | Zinc finger protein, putative; TAIR: AT1G74770.1 zinc ion binding protein; Swiss-Prot: sp|F4HVS0|BTSL2_ARATH Zinc finger protein BRUTUS-like At1g74770; TrEMBL-Plants: tr|I1MTQ0|I1MTQ0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0244600 | 31 | ||
– | Zinc finger protein, putative; TAIR: AT1G74770.1 zinc ion binding protein; Swiss-Prot: sp|F4HVS0|BTSL2_ARATH Zinc finger protein BRUTUS-like At1g74770; TrEMBL-Plants: tr|I1MTQ0|I1MTQ0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0244600 | 31 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|A0ZT53|A0ZT53_LOTJA Putative E3 ubiquitin ligase; Found in the gene: LotjaGi4g1v0453800 | 26 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|A0ZT53|A0ZT53_LOTJA Putative E3 ubiquitin ligase; Found in the gene: LotjaGi4g1v0453800 | 26 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|A0ZT53|A0ZT53_LOTJA Putative E3 ubiquitin ligase; Found in the gene: LotjaGi4g1v0453800 | 23 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|A0ZT53|A0ZT53_LOTJA Putative E3 ubiquitin ligase; Found in the gene: LotjaGi4g1v0453800 | 26 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|A0ZT53|A0ZT53_LOTJA Putative E3 ubiquitin ligase; Found in the gene: LotjaGi4g1v0453800 | 26 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|A0ZT53|A0ZT53_LOTJA Putative E3 ubiquitin ligase; Found in the gene: LotjaGi4g1v0453800 | 27 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|A0ZT53|A0ZT53_LOTJA Putative E3 ubiquitin ligase; Found in the gene: LotjaGi4g1v0453800 | 26 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|A0ZT53|A0ZT53_LOTJA Putative E3 ubiquitin ligase; Found in the gene: LotjaGi4g1v0453800 | 21 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|A0ZT53|A0ZT53_LOTJA Putative E3 ubiquitin ligase; Found in the gene: LotjaGi4g1v0453800 | 23 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|K7L4Y8|K7L4Y8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0453800 | 26 | ||
– | Zinc finger protein, putative; TAIR: AT3G18290.1 zinc finger protein-like protein; Swiss-Prot: sp|Q8LPQ5|BTS_ARATH Zinc finger protein BRUTUS; TrEMBL-Plants: tr|A0ZT53|A0ZT53_LOTJA Putative E3 ubiquitin ligase; Found in the gene: LotjaGi4g1v0453800 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd16464 | CDD | 1 | 3.03 |