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IPR019974 is a XPG conserved site.
<p>Xeroderma pigmentosum (XP) [[cite:PUB00005433]] is a human autosomal recessive disease, characterised by a high incidence of sunlight-induced skin cancer. People's skin cells with this condition are hypersensitive to ultraviolet light, due to defects in the incision step of DNA excision repair. There are a minimum of seven genetic complementation groups involved in this pathway: XP-A to XP-G. XP-G is one of the most rare and phenotypically heterogeneous of XP, showing anything from slight to extreme dysfunction in DNA excision repair [[cite:PUB00004415], [cite:PUB00002851]]. XP-G can be corrected by a 133 Kd nuclear protein, XPGC [[cite:PUB00005433]]. XPGC is an acidic protein that confers normal UV resistance in expressing cells [[cite:PUB00002851]]. It is a magnesium-dependent, single-strand DNA endonuclease that makes structure-specific endonucleolytic incisions in a DNA substrate containing a duplex region and single-stranded arms [[cite:PUB00002851], [cite:PUB00004189]]. XPGC cleaves one strand of the duplex at the border with the single-stranded region [[cite:PUB00004189]].</p> <p>XPG (ERCC-5) belongs to a family of proteins that includes RAD2 from Saccharomyces cerevisiae (Baker's yeast) and rad13 from Schizosaccharomyces pombe (Fission yeast), which are single-stranded DNA endonucleases [[cite:PUB00004189], [cite:PUB00004160], [cite:PUB00097845]]; mouse and human FEN-1, a structure-specific endonuclease; RAD2 from fission yeast and RAD27 from budding yeast; fission yeast exo1, a 5'-3' double-stranded DNA exonuclease that may act in a pathway that corrects mismatched base pairs; yeast DHS1, and yeast DIN7. Sequence alignment of this family of proteins reveals that similarities are largely confined to two regions. The first is located at the N-terminal extremity (N-region) and corresponds to the first 95 to 105 amino acids. The second region is internal (I-region) and found towards the C terminus; it spans about 140 residues and contains a highly conserved core of 27 amino acids that includes a conserved pentapeptide (E-A-[DE]-A-[QS]). It is possible that the conserved acidic residues are involved in the catalytic mechanism of DNA excision repair in XPG. The amino acids linking the N-and I-regions are not conserved.</p> <p>The first pattern, [prosite:PS00841], corresponds to the central part of the N-region, the second pattern, [prosite:PS00842], is part of the I-region and includes the putative catalytic core pentapeptide.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | Hydrolase activity, acting on ester bonds | Catalysis of the hydrolysis of any ester bond. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: LOW QUALITY PROTEIN: DNA repair protein UVH3-like [Glycine max] gi|356498232|ref|XP_003517957.1| | 20 | ||
– | PREDICTED: exonuclease 1-like [Cicer arietinum] gi|502140539|ref|XP_004504251.1| | 24 | ||
– | PREDICTED: flap endonuclease 1-like isoform X3 [Cicer arietinum] gi|502117445|ref|XP_004495823.1| | 19 | ||
– | PREDICTED: flap endonuclease 1-like isoform X3 [Cicer arietinum] gi|502117445|ref|XP_004495823.1| | 23 | ||
– | Flap endonuclease 1; TAIR: AT3G28030.1 5'-3' exonuclease family protein; Swiss-Prot: sp|Q9ATY5|UVH3_ARATH DNA repair protein UVH3; TrEMBL-Plants: tr|K7K2I9|K7K2I9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0605700 | 20 | ||
– | Flap endonuclease 1; TAIR: AT3G28030.1 5'-3' exonuclease family protein; Swiss-Prot: sp|Q9ATY5|UVH3_ARATH DNA repair protein UVH3; TrEMBL-Plants: tr|K7K2I9|K7K2I9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0605700 | 26 | ||
– | Flap endonuclease 1; TAIR: AT3G28030.1 5'-3' exonuclease family protein; Swiss-Prot: sp|Q9ATY5|UVH3_ARATH DNA repair protein UVH3; TrEMBL-Plants: tr|K7K2I9|K7K2I9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0605700 | 24 | ||
– | Flap endonuclease 1; TAIR: AT1G29630.2 5'-3' exonuclease family protein; Swiss-Prot: sp|Q60GC1|EXO1_ORYSJ Exonuclease 1; TrEMBL-Plants: tr|K7L667|K7L667_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0382400 | 25 | ||
– | Flap endonuclease 1; TAIR: AT5G26680.2 5'-3' exonuclease family protein; Swiss-Prot: sp|C6TEX6|FEN1_SOYBN Flap endonuclease 1; TrEMBL-Plants: tr|I3SAA1|I3SAA1_LOTJA Flap endonuclease 1; Found in the gene: LotjaGi5g1v0234800 | 27 | ||
– | Flap endonuclease 1; TAIR: AT5G26680.3 5'-3' exonuclease family protein; Swiss-Prot: sp|C6TEX6|FEN1_SOYBN Flap endonuclease 1; TrEMBL-Plants: tr|A0A072VM97|A0A072VM97_MEDTR Flap endonuclease 1; Found in the gene: LotjaGi5g1v0234800 | 26 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd09907 | CDD | 1 | 10.00 |