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IPR033010

Source: InterPro

Description

IPR033010 is a WD repeat Cdc20/Fizzy.

<p>The anaphase promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that targets mitotic regulators for degradation in exit from mitosis. At the end of mitosis, APC/C is activated by phosphorylation and association with the WD-40 protein Cdc20/Fizzy [[cite:PUB00077383]]. The inhibitory phosphorylation of Cdc20/Fizzy may have a role as a safeguard to keep the cyclosome inactive in early mitosis and under conditions of mitotic checkpoint arrest [[cite:PUB00077383]]. This entry includes Cdc20/Fizzy homologues from fungi, plants and animals.</p> <p>Three characterised budding yeasts homologues are included in this entry: Cdc20, Cdh1 and Ama1. Cdc20 and Cdh1 have been shown to activate APC/C during mitosis, while Ama1 is a meiosis-specific activator of the APC/C [[cite:PUB00077391]]. The APC/C-Cdh1 is also found involved in the cellular response to DNA damage [[cite:PUB00077392]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0010997
Molecular function Anaphase-promoting complex binding Interacting selectively and non-covalently with an anaphase-promoting complex. A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis.
Subterm of
GO:0097027
Molecular function Ubiquitin-protein transferase activator activity Increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein.
Subterm of
GO:1904668
Biological process Positive regulation of ubiquitin protein ligase activity Any process that activates or increases the frequency, rate or extent of ubiquitin protein ligase activity.
Subterm of

Associated Lotus transcripts 38

Transcript Name Description Predicted domains Domain count
Lj0g3v0012509.1
– PREDICTED: anaphase-promoting complex subunit cdc20-like [Glycine max] gi|356533257|ref|XP_003535182.1|
Domains
16
Lj0g3v0096189.1
– PREDICTED: anaphase-promoting complex subunit cdc20-like [Cicer arietinum] gi|502122681|ref|XP_004497861.1|
Domains
16
Lj0g3v0232589.1
– PREDICTED: anaphase-promoting complex subunit cdc20-like [Glycine max] gi|356533257|ref|XP_003535182.1|
Domains
16
Lj0g3v0283109.1
– WD-repeat cell cycle regulatory protein [Glycine max] gi|351727655|ref|NP_001237168.1|
Domains
17
Lj0g3v0283109.3
– PREDICTED: protein FIZZY-RELATED 3-like [Glycine max] gi|356569370|ref|XP_003552875.1|
Domains
17
Lj0g3v0310479.1
– PREDICTED: anaphase-promoting complex subunit cdc20-like [Glycine max] gi|356533257|ref|XP_003535182.1|
Domains
16
Lj1g3v4753210.1
– PREDICTED: anaphase-promoting complex subunit cdc20-like [Cicer arietinum] gi|502112266|ref|XP_004494277.1|
Domains
18
Lj2g3v2003020.1
– PREDICTED: protein FIZZY-RELATED 2-like [Glycine max] gi|356565305|ref|XP_003550882.1|
Domains
19
Lj2g3v2124610.1
– PREDICTED: anaphase-promoting complex subunit cdc20-like [Glycine max] gi|356497369|ref|XP_003517533.1|
Domains
15
Lj3g3v1906530.1
– PREDICTED: anaphase-promoting complex subunit cdc20 [Vitis vinifera] gi|225463838|ref|XP_002264396.1|
Domains
17
Lj4g3v1287260.1
– PREDICTED: protein FIZZY-RELATED 2-like [Glycine max] gi|356565305|ref|XP_003550882.1|
Domains
18
Lj4g3v1327590.1
– Cell cycle switch protein CCS52A [Lotus japonicus] gi|66932877|gb|AAY58271.1|
Domains
17
Lj4g3v1327590.2
– Cell cycle switch protein CCS52A [Lotus japonicus] gi|66932877|gb|AAY58271.1|
Domains
17
Lj6g3v0145990.1
– PREDICTED: anaphase-promoting complex subunit cdc20-like [Cicer arietinum] gi|502122681|ref|XP_004497861.1|
Domains
14
Lj6g3v0156180.1
– PREDICTED: anaphase-promoting complex subunit cdc20-like [Cicer arietinum] gi|502122681|ref|XP_004497861.1|
Domains
16
Lj6g3v0156180.2
– PREDICTED: anaphase-promoting complex subunit cdc20-like [Cicer arietinum] gi|502122681|ref|XP_004497861.1|
Domains
12
Lj6g3v0157220.1
– PREDICTED: anaphase-promoting complex subunit cdc20-like [Glycine max] gi|356533257|ref|XP_003535182.1|
Domains
15
LotjaGi1g1v0202500.1
– WD-repeat protein; TAIR: AT4G33270.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q54MZ3|CDC20_DICDI Anaphase-promoting complex subunit cdc20; TrEMBL-Plants: tr|A0A151SFQ0|A0A151SFQ0_CAJCA Anaphase-promoting complex subunit cdc20; Found in the gene: LotjaGi1g1v0202500
Domains
17
LotjaGi1g1v0210300.1
– WD-repeat protein; TAIR: AT4G33260.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9SZA4|CDC21_ARATH Cell division cycle 20.1, cofactor of APC complex; TrEMBL-Plants: tr|K7LIT2|K7LIT2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0210300
Domains
17
LotjaGi1g1v0673600.1
– WD-repeat protein; TAIR: AT4G33270.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q54MZ3|CDC20_DICDI Anaphase-promoting complex subunit cdc20; TrEMBL-Plants: tr|A0A1J7HIB5|A0A1J7HIB5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0673600
Domains
17
LotjaGi1g1v0673600.2
– WD-repeat protein; TAIR: AT4G33270.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q54MZ3|CDC20_DICDI Anaphase-promoting complex subunit cdc20; TrEMBL-Plants: tr|K7LIT2|K7LIT2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0673600
Domains
17
LotjaGi1g1v0673600.3
– WD-repeat protein; TAIR: AT4G33270.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q54MZ3|CDC20_DICDI Anaphase-promoting complex subunit cdc20; TrEMBL-Plants: tr|A0A1J7HIB5|A0A1J7HIB5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0673600
Domains
17
LotjaGi1g1v0740400.1
– WD-repeat cell cycle regulatory protein; TAIR: AT4G33270.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9SZA4|CDC21_ARATH Cell division cycle 20.1, cofactor of APC complex; TrEMBL-Plants: tr|A5BP73|A5BP73_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi1g1v0740400
Domains
19
LotjaGi2g1v0429800.1
– WD-repeat protein, putative; TAIR: AT4G22910.1 FIZZY-related 2; Swiss-Prot: sp|Q8L3Z8|FZR2_ARATH Protein FIZZY-RELATED 2; TrEMBL-Plants: tr|A0A024FRG3|A0A024FRG3_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0429800
Domains
19
LotjaGi2g1v0447700.1
– WD-repeat cell cycle regulatory protein; TAIR: AT4G33270.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9SZA4|CDC21_ARATH Cell division cycle 20.1, cofactor of APC complex; TrEMBL-Plants: tr|A0A0L9TAL3|A0A0L9TAL3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0447700
Domains
18
LotjaGi3g1v0132100_LC.1
– WD repeat-containing protein 1; TAIR: AT4G33260.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9SZA4|CDC21_ARATH Cell division cycle 20.1, cofactor of APC complex; TrEMBL-Plants: tr|K7LIT2|K7LIT2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0132100_LC
Domains
14
LotjaGi3g1v0132200_LC.1
– WD-repeat protein; TAIR: AT4G33260.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9SZA4|CDC21_ARATH Cell division cycle 20.1, cofactor of APC complex; TrEMBL-Plants: tr|K7LIT2|K7LIT2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0132200_LC
Domains
17
LotjaGi3g1v0220800.1
– WD-repeat cell cycle regulatory protein; TAIR: AT4G33270.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9SZA4|CDC21_ARATH Cell division cycle 20.1, cofactor of APC complex; TrEMBL-Plants: tr|A5BP73|A5BP73_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0220800
Domains
19
LotjaGi3g1v0220800.2
– WD-repeat protein; TAIR: AT4G33270.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9SZA4|CDC21_ARATH Cell division cycle 20.1, cofactor of APC complex; TrEMBL-Plants: tr|A5BP73|A5BP73_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0220800
Domains
19
LotjaGi3g1v0316200.1
– WD-repeat cell cycle regulatory protein; TAIR: AT4G33260.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9SZA4|CDC21_ARATH Cell division cycle 20.1, cofactor of APC complex; TrEMBL-Plants: tr|A5BP73|A5BP73_VITVI Putative uncharacterized protein; Found in the gene: LotjaGi3g1v0316200
Domains
18
LotjaGi4g1v0217500.1
– WD-repeat protein, putative; TAIR: AT4G22910.1 FIZZY-related 2; Swiss-Prot: sp|Q8L3Z8|FZR2_ARATH Protein FIZZY-RELATED 2; TrEMBL-Plants: tr|A0A024FSI1|A0A024FSI1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0217500
Domains
18
LotjaGi4g1v0217500.2
– WD-repeat protein, putative; TAIR: AT4G22910.1 FIZZY-related 2; Swiss-Prot: sp|Q8L3Z8|FZR2_ARATH Protein FIZZY-RELATED 2; TrEMBL-Plants: tr|A0A024FSI1|A0A024FSI1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0217500
Domains
18
LotjaGi4g1v0217500.3
– WD-repeat protein, putative; TAIR: AT4G22910.1 FIZZY-related 2; Swiss-Prot: sp|Q8L3Z8|FZR2_ARATH Protein FIZZY-RELATED 2; TrEMBL-Plants: tr|A0A024FSI1|A0A024FSI1_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0217500
Domains
17
LotjaGi6g1v0016000.1
– WD-repeat protein; TAIR: AT4G33270.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q54MZ3|CDC20_DICDI Anaphase-promoting complex subunit cdc20; TrEMBL-Plants: tr|A0A151SFQ0|A0A151SFQ0_CAJCA Anaphase-promoting complex subunit cdc20; Found in the gene: LotjaGi6g1v0016000
Domains
17
LotjaGi6g1v0017200_LC.1
– WD-repeat protein; TAIR: AT4G33270.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9SZA4|CDC21_ARATH Cell division cycle 20.1, cofactor of APC complex; TrEMBL-Plants: tr|A0A1J7HIB5|A0A1J7HIB5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0017200_LC
Domains
17
LotjaGi6g1v0018900.1
– WD-repeat protein; TAIR: AT4G33260.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9S7I8|CDC22_ARATH Cell division cycle 20.2, cofactor of APC complex; TrEMBL-Plants: tr|K7LIT2|K7LIT2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0018900
Domains
17
LotjaGi6g1v0019100_LC.1
– WD-repeat protein; TAIR: AT4G33270.1 Transducin family protein / WD-40 repeat family protein; Swiss-Prot: sp|Q9SZA4|CDC21_ARATH Cell division cycle 20.1, cofactor of APC complex; TrEMBL-Plants: tr|K7LIT2|K7LIT2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0019100_LC
Domains
17
LotjaGi6g1v0062300.1
– WD-repeat cell cycle regulatory protein; TAIR: AT5G13840.1 FIZZY-related 3; Swiss-Prot: sp|Q8LPL5|FZR3_ARATH Protein FIZZY-RELATED 3; TrEMBL-Plants: tr|A0A0L9U9C3|A0A0L9U9C3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0062300
Domains
17

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 2.63