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Field | Value |
---|---|
Namespace | Biological process |
Short description | Clathrin coat assembly |
Full defintion | The process that results in the assembly of clathrin triskelia into the ordered structure known as a clathrin cage. |
Subterm of |
The relationship of GO:0048268 with other GO terms.
Relationship type | GO terms |
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Is a | |
Regulates | n.a. |
Part of | n.a. |
Positively regulates | n.a. |
Negatively regulates | n.a. |
A force layout showing the ancestor tree for GO:0048268, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.
This table contains additional metadata associated with the GO entry's definition field.
Field | Value |
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GOC | jid |
PMID | Pan1p, yeast eps15, functions as a multivalent adaptor that coordinates protein-protein interactions essential for endocytosis. J Cell Biol. 1998 Apr 6; 141 (1): 71–84.PMID: 9531549 A genetic screen for factors required for endocytosis in the budding yeast Saccharomyces cerevisiae previously identified PAN1. Pan1p is a homologue of the mammalian protein eps15, which has been implicated in endocytosis by virtue of its association with the plasma membrane clathrin adaptor complex AP-2. Pan1p contains two eps15 homology (EH) domains, a protein-protein interaction motif also present in other proteins that function in membrane trafficking. To address the role of Pan1p and EH domains in endocytosis, a yeast two-hybrid screen was performed using the EH domain-containing region of Pan1p. This screen identified yAP180A, one of two yeast homologues of a class of clathrin assembly proteins (AP180) that exhibit in vitro clathrin cage assembly activity. In vitro binding studies using GST fusion proteins and yeast extracts defined distinct binding sites on yAP180A for Pan1p and clathrin. yAP180 proteins and Pan1p, like actin, localize to peripheral patches along the plasma membrane. Mammalian synaptojanin, a phosphatidylinositol polyphosphate-5-phosphatase, also has been implicated in endocytosis recently, and three synaptojanin-like genes have been identified in yeast. We observed genetic interactions between the yeast SJL1 gene and PAN1, which suggest a role for phosphoinositide metabolites in Pan1p function. Together with other studies, these findings suggest that Pan1p coordinates regulatory interactions between proteins required for both endocytosis and actin-cytoskeleton organization; these proteins include the yAP180 proteins, clathrin, the ubiquitin-protein ligase Rsp5p, End3p, and synaptojanin. We suggest that Pan1p (and by extension eps15) serves as a multivalent adaptor around which dynamic interactions between structural and regulatory components of the endocytic pathway converge. |
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
Transcript | Name | Description | GO terms | GO count |
---|---|---|---|---|
– | Epsin N-terminal homology (ENTH) domain-containing protein [Medicago truncatula] gi|357466187|ref|XP_003603378.1| | 4 | ||
– | Epsin N-terminal domain-containing protein / clathrin assembly protein-related isoform 1 [Theobroma cacao] gi|508782208|gb|EOY29464.1| | 4 | ||
– | 4 | |||
– | ENTH/ANTH/VHS superfamily protein [Theobroma cacao] gi|508706974|gb|EOX98870.1| | 4 | ||
– | Epsin N-terminal homology (ENTH) domain-containing protein [Medicago truncatula] gi|357478179|ref|XP_003609375.1| | 4 | ||
– | ENTH/ANTH/VHS superfamily protein isoform 1 [Theobroma cacao] gi|508783924|gb|EOY31180.1| | 4 | ||
– | Phosphoprotein-like protein [Medicago truncatula] gi|357479541|ref|XP_003610056.1| | 4 | ||
– | ENTH/VHS/GAT family protein [Arabidopsis thaliana] gi|15222535|ref|NP_173895.1| | 4 | ||
– | ENTH/ANTH/VHS superfamily protein [Theobroma cacao] gi|508709143|gb|EOY01040.1| | 4 | ||
– | ENTH/ANTH/VHS superfamily protein [Theobroma cacao] gi|508706974|gb|EOX98870.1| | 4 | ||
– | Clathrin assembly family protein; TAIR: AT2G25430.1 epsin N-terminal homology (ENTH) domain-containing protein / clathrin assembly protein-like protein; Swiss-Prot: sp|Q8LF20|CAP2_ARATH Putative clathrin assembly protein At2g25430; TrEMBL-Plants: tr|A0A151RLK9|A0A151RLK9_CAJCA Putative clathrin assembly protein family; Found in the gene: LotjaGi1g1v0382900 | 4 | ||
– | Clathrin assembly family protein; TAIR: AT2G25430.1 epsin N-terminal homology (ENTH) domain-containing protein / clathrin assembly protein-like protein; Swiss-Prot: sp|Q8LF20|CAP2_ARATH Putative clathrin assembly protein At2g25430; TrEMBL-Plants: tr|A0A151RLK9|A0A151RLK9_CAJCA Putative clathrin assembly protein family; Found in the gene: LotjaGi1g1v0382900 | 4 | ||
– | Clathrin assembly family protein; TAIR: AT2G25430.1 epsin N-terminal homology (ENTH) domain-containing protein / clathrin assembly protein-like protein; Swiss-Prot: sp|Q8LF20|CAP2_ARATH Putative clathrin assembly protein At2g25430; TrEMBL-Plants: tr|A0A151RLK9|A0A151RLK9_CAJCA Putative clathrin assembly protein family; Found in the gene: LotjaGi1g1v0382900 | 4 | ||
– | ENTH/ANTH/VHS superfamily protein; TAIR: AT1G25240.1 ENTH/VHS/GAT family protein; Swiss-Prot: sp|Q9FRH3|CAP13_ARATH Putative clathrin assembly protein At1g25240; TrEMBL-Plants: tr|A0A151R3S9|A0A151R3S9_CAJCA Putative clathrin assembly protein family; Found in the gene: LotjaGi2g1v0007300 | 4 | ||
– | Clathrin assembly family protein; TAIR: AT1G03050.1 ENTH/ANTH/VHS superfamily protein; Swiss-Prot: sp|Q9SA65|CAP4_ARATH Putative clathrin assembly protein At1g03050; TrEMBL-Plants: tr|A0A1J7IJM8|A0A1J7IJM8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0032300 | 4 | ||
– | Clathrin assembly family protein; TAIR: AT2G25430.1 epsin N-terminal homology (ENTH) domain-containing protein / clathrin assembly protein-like protein; Swiss-Prot: sp|Q8LF20|CAP2_ARATH Putative clathrin assembly protein At2g25430; TrEMBL-Plants: tr|I1LZP6|I1LZP6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0273600 | 4 | ||
– | ENTH/ANTH/VHS superfamily protein; TAIR: AT5G35200.1 ENTH/ANTH/VHS superfamily protein; Swiss-Prot: sp|Q9LHS0|CAP10_ARATH Putative clathrin assembly protein At5g35200; TrEMBL-Plants: tr|I3SKY7|I3SKY7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0275800 | 4 | ||
– | ENTH/ANTH/VHS superfamily protein; TAIR: AT5G35200.1 ENTH/ANTH/VHS superfamily protein; Swiss-Prot: sp|Q9LHS0|CAP10_ARATH Putative clathrin assembly protein At5g35200; TrEMBL-Plants: tr|I3SKY7|I3SKY7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0275800 | 4 | ||
– | ENTH/ANTH/VHS superfamily protein; TAIR: AT5G35200.1 ENTH/ANTH/VHS superfamily protein; Swiss-Prot: sp|Q9LHS0|CAP10_ARATH Putative clathrin assembly protein At5g35200; TrEMBL-Plants: tr|I3SKY7|I3SKY7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0275800 | 4 | ||
– | ENTH/ANTH/VHS superfamily protein; TAIR: AT4G25940.1 ENTH/ANTH/VHS superfamily protein; Swiss-Prot: sp|Q8VYT2|CAP6_ARATH Putative clathrin assembly protein At4g25940; TrEMBL-Plants: tr|I1LVM2|I1LVM2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0305400 | 4 | ||
– | ENTH/ANTH/VHS superfamily protein; TAIR: AT1G25240.1 ENTH/VHS/GAT family protein; Swiss-Prot: sp|Q9FRH3|CAP13_ARATH Putative clathrin assembly protein At1g25240; TrEMBL-Plants: tr|I1K3B5|I1K3B5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0354300 | 4 | ||
– | ENTH/ANTH/VHS superfamily protein; TAIR: AT2G01600.1 ENTH/ANTH/VHS superfamily protein; Swiss-Prot: sp|Q8LBH2|CAP8_ARATH Putative clathrin assembly protein At2g01600; TrEMBL-Plants: tr|A0A151T2E9|A0A151T2E9_CAJCA Putative clathrin assembly protein family; Found in the gene: LotjaGi4g1v0358800 | 4 | ||
– | Clathrin assembly protein; TAIR: AT1G05020.1 ENTH/ANTH/VHS superfamily protein; Swiss-Prot: sp|Q9ZVN6|AP180_ARATH Clathrin coat assembly protein AP180; TrEMBL-Plants: tr|K7LYR1|K7LYR1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0022100 | 4 | ||
– | Clathrin assembly protein; TAIR: AT1G05020.1 ENTH/ANTH/VHS superfamily protein; Swiss-Prot: sp|Q9ZVN6|AP180_ARATH Clathrin coat assembly protein AP180; TrEMBL-Plants: tr|K7LYR1|K7LYR1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0022100 | 4 | ||
– | ENTH/ANTH/VHS superfamily protein; TAIR: AT5G35200.1 ENTH/ANTH/VHS superfamily protein; Swiss-Prot: sp|Q9LHS0|CAP10_ARATH Putative clathrin assembly protein At5g35200; TrEMBL-Plants: tr|A0A072TEL9|A0A072TEL9_MEDTR Clathrin assembly protein; Found in the gene: LotjaGi6g1v0199000 | 4 | ||
– | ENTH/ANTH/VHS superfamily protein; TAIR: AT4G25940.1 ENTH/ANTH/VHS superfamily protein; Swiss-Prot: sp|Q8VYT2|CAP6_ARATH Putative clathrin assembly protein At4g25940; TrEMBL-Plants: tr|A0A151T5F7|A0A151T5F7_CAJCA Putative clathrin assembly protein family; Found in the gene: LotjaGi6g1v0235700 | 4 | ||
– | Clathrin assembly family protein; TAIR: AT1G03050.1 ENTH/ANTH/VHS superfamily protein; Swiss-Prot: sp|Q9SA65|CAP4_ARATH Putative clathrin assembly protein At1g03050; TrEMBL-Plants: tr|A0A1J7GTW2|A0A1J7GTW2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0355400 | 4 | ||
– | Clathrin assembly family protein; TAIR: AT1G03050.1 ENTH/ANTH/VHS superfamily protein; Swiss-Prot: sp|Q9SA65|CAP4_ARATH Putative clathrin assembly protein At1g03050; TrEMBL-Plants: tr|A0A1J7GTW2|A0A1J7GTW2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0355400 | 4 |
A list of co-occurring GO terms within the L. japonicus gene space:
GO term | Namespace | Name | Observations | Saturation (%) |
---|---|---|---|---|
Biological process | Clathrin coat assembly | 1 | 3.57 |