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IPR004838 is a Aminotransferases, class-I, pyridoxal-phosphate-binding site.
<p>Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [[cite:PUB00035505], [cite:PUB00006322], [cite:PUB00035506]]. PLP-dependent enzymes are primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but they are also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters; pyridoxal phosphate can also inhibit DNA polymerases and several steroid receptors [[cite:PUB00035507]]. Inadequate levels of pyridoxal phosphate in the brain can cause neurological dysfunction, particularly epilepsy [[cite:PUB00035508]].</p> <p>PLP enzymes exist in their resting state as a Schiff base, the aldehyde group of PLP forming a linkage with the ε-amino group of an active site lysine residue on the enzyme. The α-amino group of the substrate displaces the lysine ε-amino group, in the process forming a new aldimine with the substrate. This aldimine is the common central intermediate for all PLP-catalysed reactions, enzymatic and non-enzymatic [[cite:PUB00035504]].</p> <p>Aminotransferases share certain mechanistic features with other pyridoxal-phosphate dependent enzymes, such as the covalent binding of the pyridoxal-phosphate group to a lysine residue. On the basis of sequence similarity, these various enzymes can be grouped [[cite:PUB00002679]] into subfamilies; these sequences are defined by the aminotransferases class-I pyridoxal-phosphate attachment site signature, which contains the lysine residue involved in pyridoxal-phosphate binding.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Molecular function | Catalytic activity | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. | ||
| Biological process | Biosynthetic process | The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. | ||
| Molecular function | Pyridoxal phosphate binding | Interacting selectively and non-covalently with pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: probable aminotransferase TAT2-like isoform X1 [Cicer arietinum] gi|502082746|ref|XP_004487261.1| | 18 | ||
| – | PREDICTED: probable aminotransferase TAT2-like isoform X1 [Cicer arietinum] gi|502082746|ref|XP_004487261.1| | 16 | ||
| – | PREDICTED: probable aminotransferase ACS12-like [Glycine max] gi|356529344|ref|XP_003533255.1| | 19 | ||
| – | 1-aminocyclopropane-1-carboxylic acid synthase [Vigna radiata] gi|5231127|gb|AAD41083.1|AF151961_1 | 14 | ||
| – | PREDICTED: callose synthase 5-like [Cicer arietinum] gi|502137024|ref|XP_004502937.1| | 11 | ||
| – | Aspartate aminotransferase [Lotus japonicus] gi|1122288|emb|CAA63894.1| | 13 | ||
| – | PREDICTED: 1-aminocyclopropane-1-carboxylate synthase 1-like [Cicer arietinum] gi|502105402|ref|XP_004492797.1| | 14 | ||
| – | PREDICTED: 1-aminocyclopropane-1-carboxylate synthase 7-like [Glycine max] gi|356523125|ref|XP_003530192.1| | 15 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase [Medicago truncatula] gi|357482497|ref|XP_003611535.1| | 15 | ||
| – | PREDICTED: 1-aminocyclopropane-1-carboxylate synthase-like [Glycine max] gi|356539620|ref|XP_003538294.1| | 15 | ||
| – | Aspartate aminotransferase [Medicago truncatula] gi|357474641|ref|XP_003607605.1| | 13 | ||
| – | PREDICTED: aspartate aminotransferase, mitochondrial-like [Cicer arietinum] gi|502143818|ref|XP_004505477.1| | 13 | ||
| – | PREDICTED: bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase-like isoform X2 [Cicer arietinum] gi|502147677|ref|XP_004506873.1| | 13 | ||
| – | PREDICTED: probable aminotransferase TAT2-like isoform X2 [Cicer arietinum] gi|502082749|ref|XP_004487262.1| | 16 | ||
| – | PREDICTED: probable aminotransferase TAT2-like isoform X1 [Cicer arietinum] gi|502082746|ref|XP_004487261.1| | 16 | ||
| – | PREDICTED: probable aminotransferase TAT2-like isoform X1 [Cicer arietinum] gi|502082746|ref|XP_004487261.1| | 16 | ||
| – | 1-aminocyclopropane-1-carboxylic acid synthase [Vigna radiata] gi|5231127|gb|AAD41083.1|AF151961_1 | 14 | ||
| – | PREDICTED: bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase-like [Cicer arietinum] gi|502140078|ref|XP_004504047.1| | 13 | ||
| – | PREDICTED: 1-aminocyclopropane-1-carboxylate synthase-like [Cicer arietinum] gi|502139181|ref|XP_004503673.1| | 15 | ||
| – | PREDICTED: 1-aminocyclopropane-1-carboxylate synthase 7-like [Glycine max] gi|356523125|ref|XP_003530192.1| | 14 | ||
| – | Aspartate aminotransferase [Lotus corniculatus] gi|2605932|gb|AAC12674.1| | 15 | ||
| – | Aspartate aminotransferase [Lotus corniculatus] gi|2605932|gb|AAC12674.1| | 12 | ||
| – | PREDICTED: kynurenine--oxoglutarate transaminase 1-like isoform X1 [Cicer arietinum] gi|502117747|ref|XP_004495926.1| | 13 | ||
| – | PREDICTED: bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase-like [Cicer arietinum] gi|502140078|ref|XP_004504047.1| | 13 | ||
| – | Callose synthase; TAIR: AT2G13680.1 callose synthase 5; Swiss-Prot: sp|Q3B724|CALS5_ARATH Callose synthase 5; TrEMBL-Plants: tr|G7JBJ9|G7JBJ9_MEDTR Glucan synthase-like protein; Found in the gene: LotjaGi1g1v0319000 | 18 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase; TAIR: AT4G37770.1 1-amino-cyclopropane-1-carboxylate synthase 8; Swiss-Prot: sp|Q00257|1A12_CUCMA 1-aminocyclopropane-1-carboxylate synthase CMA101; TrEMBL-Plants: tr|A0A0B2R8A7|A0A0B2R8A7_GLYSO 1-aminocyclopropane-1-carboxylate synthase 8; Found in the gene: LotjaGi1g1v0364000_LC | 14 | ||
| – | Aspartate aminotransferase; TAIR: AT5G11520.1 aspartate aminotransferase 3; Swiss-Prot: sp|P28011|AAT1_MEDSA Aspartate aminotransferase 1; TrEMBL-Plants: tr|Q43781|Q43781_LOTJA Aspartate aminotransferase; Found in the gene: LotjaGi1g1v0400200 | 16 | ||
| – | Aspartate aminotransferase; TAIR: AT5G11520.1 aspartate aminotransferase 3; Swiss-Prot: sp|P28011|AAT1_MEDSA Aspartate aminotransferase 1; TrEMBL-Plants: tr|Q43781|Q43781_LOTJA Aspartate aminotransferase; Found in the gene: LotjaGi1g1v0400200 | 15 | ||
| – | Aspartate aminotransferase; TAIR: AT5G11520.1 aspartate aminotransferase 3; Swiss-Prot: sp|P28011|AAT1_MEDSA Aspartate aminotransferase 1; TrEMBL-Plants: tr|Q43781|Q43781_LOTJA Aspartate aminotransferase; Found in the gene: LotjaGi1g1v0400200 | 15 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase; TAIR: AT3G61510.1 ACC synthase 1; Swiss-Prot: sp|Q9MB95|1A11_PRUMU 1-aminocyclopropane-1-carboxylate synthase 1; TrEMBL-Plants: tr|I1N3V1|I1N3V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0481200 | 14 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase; TAIR: AT3G61510.1 ACC synthase 1; Swiss-Prot: sp|Q9MB95|1A11_PRUMU 1-aminocyclopropane-1-carboxylate synthase 1; TrEMBL-Plants: tr|I1N3V1|I1N3V1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0481200 | 14 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase; TAIR: AT5G51690.1 1-amino-cyclopropane-1-carboxylate synthase 12; Swiss-Prot: sp|Q8GYY0|1A112_ARATH Probable aminotransferase ACS12; TrEMBL-Plants: tr|A0A151T460|A0A151T460_CAJCA Putative aminotransferase ACS12; Found in the gene: LotjaGi2g1v0159300 | 19 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase; TAIR: AT4G26200.1 1-amino-cyclopropane-1-carboxylate synthase 7; Swiss-Prot: sp|Q9STR4|1A17_ARATH 1-aminocyclopropane-1-carboxylate synthase 7; TrEMBL-Plants: tr|A0A151RGL0|A0A151RGL0_CAJCA 1-aminocyclopropane-1-carboxylate synthase 7; Found in the gene: LotjaGi2g1v0230900 | 15 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase; TAIR: AT4G37770.1 1-amino-cyclopropane-1-carboxylate synthase 8; Swiss-Prot: sp|Q00257|1A12_CUCMA 1-aminocyclopropane-1-carboxylate synthase CMA101; TrEMBL-Plants: tr|G7K167|G7K167_MEDTR 1-aminocyclopropane-1-carboxylate synthase; Found in the gene: LotjaGi2g1v0412200 | 15 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase; TAIR: AT4G11280.1 1-aminocyclopropane-1-carboxylic acid (acc) synthase 6; Swiss-Prot: sp|P31531|1A1C_SOYBN 1-aminocyclopropane-1-carboxylate synthase; TrEMBL-Plants: tr|I1LGD4|I1LGD4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0436200 | 15 | ||
| – | Aspartate aminotransferase; TAIR: AT2G30970.1 aspartate aminotransferase 1; Swiss-Prot: sp|P46643|AAT1_ARATH Aspartate aminotransferase, mitochondrial; TrEMBL-Plants: tr|G7JCN3|G7JCN3_MEDTR Aspartate aminotransferase; Found in the gene: LotjaGi3g1v0253000 | 15 | ||
| – | Aminotransferase; TAIR: AT1G80360.1 Pyridoxal phosphate (PLP)-dependent transferases superfamily protein; Swiss-Prot: sp|Q9V0L2|AAT_PYRAB Aspartate aminotransferase; TrEMBL-Plants: tr|I3SYN6|I3SYN6_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0361400 | 13 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase 1; TAIR: AT1G01480.1 1-amino-cyclopropane-1-carboxylate synthase 2; Swiss-Prot: sp|Q9MB95|1A11_PRUMU 1-aminocyclopropane-1-carboxylate synthase 1; TrEMBL-Plants: tr|A0A1J7HI44|A0A1J7HI44_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0387700 | 16 | ||
| – | Aminotransferase-related family protein; TAIR: AT5G53970.1 Tyrosine transaminase family protein; Swiss-Prot: sp|Q9FN30|TAT2_ARATH Probable aminotransferase TAT2; TrEMBL-Plants: tr|A0A151SF02|A0A151SF02_CAJCA Tyrosine aminotransferase; Found in the gene: LotjaGi3g1v0446400 | 15 | ||
| – | Aminotransferase-related family protein; TAIR: AT5G53970.1 Tyrosine transaminase family protein; Swiss-Prot: sp|Q9FN30|TAT2_ARATH Probable aminotransferase TAT2; TrEMBL-Plants: tr|I1LUI0|I1LUI0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0446400 | 16 | ||
| – | Aminotransferase-related family protein; TAIR: AT5G53970.1 Tyrosine transaminase family protein; Swiss-Prot: sp|Q9FN30|TAT2_ARATH Probable aminotransferase TAT2; TrEMBL-Plants: tr|A0A072VBJ4|A0A072VBJ4_MEDTR Tyrosine/nicotianamine family aminotransferase; Found in the gene: LotjaGi3g1v0446400 | 16 | ||
| – | Aminotransferase-related family protein; TAIR: AT5G53970.1 Tyrosine transaminase family protein; Swiss-Prot: sp|Q9FN30|TAT2_ARATH Probable aminotransferase TAT2; TrEMBL-Plants: tr|A0A072VBJ4|A0A072VBJ4_MEDTR Tyrosine/nicotianamine family aminotransferase; Found in the gene: LotjaGi3g1v0446400 | 16 | ||
| – | Aminotransferase-related family protein; TAIR: AT5G53970.1 Tyrosine transaminase family protein; Swiss-Prot: sp|Q9FN30|TAT2_ARATH Probable aminotransferase TAT2; TrEMBL-Plants: tr|A0A0B2R6V7|A0A0B2R6V7_GLYSO Tyrosine aminotransferase; Found in the gene: LotjaGi3g1v0446400 | 16 | ||
| – | Aminotransferase-related family protein; TAIR: AT5G53970.1 Tyrosine transaminase family protein; Swiss-Prot: sp|Q9FN30|TAT2_ARATH Probable aminotransferase TAT2; TrEMBL-Plants: tr|A0A072VBJ4|A0A072VBJ4_MEDTR Tyrosine/nicotianamine family aminotransferase; Found in the gene: LotjaGi3g1v0446400 | 16 | ||
| – | Aminotransferase-related family protein; TAIR: AT5G53970.1 Tyrosine transaminase family protein; Swiss-Prot: sp|Q9FN30|TAT2_ARATH Probable aminotransferase TAT2; TrEMBL-Plants: tr|I1LUI0|I1LUI0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0446400 | 16 | ||
| – | Aminotransferase-related family protein; TAIR: AT5G53970.1 Tyrosine transaminase family protein; Swiss-Prot: sp|Q9FN30|TAT2_ARATH Probable aminotransferase TAT2; TrEMBL-Plants: tr|A0A072VBJ4|A0A072VBJ4_MEDTR Tyrosine/nicotianamine family aminotransferase; Found in the gene: LotjaGi3g1v0446400 | 16 | ||
| – | Aminotransferase-related family protein; TAIR: AT5G53970.1 Tyrosine transaminase family protein; Swiss-Prot: sp|Q9FN30|TAT2_ARATH Probable aminotransferase TAT2; TrEMBL-Plants: tr|A0A151SF02|A0A151SF02_CAJCA Tyrosine aminotransferase; Found in the gene: LotjaGi3g1v0446400 | 16 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase; TAIR: AT4G37770.1 1-amino-cyclopropane-1-carboxylate synthase 8; Swiss-Prot: sp|Q00257|1A12_CUCMA 1-aminocyclopropane-1-carboxylate synthase CMA101; TrEMBL-Plants: tr|A0A0L9TPG9|A0A0L9TPG9_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0091800 | 14 | ||
| – | Aminotransferase; TAIR: AT2G22250.2 aspartate aminotransferase; Swiss-Prot: sp|E9L7A5|PAT_PETHY Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase; TrEMBL-Plants: tr|I1KT56|I1KT56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0400300 | 13 | ||
| – | Aminotransferase; TAIR: AT2G22250.2 aspartate aminotransferase; Swiss-Prot: sp|E9L7A5|PAT_PETHY Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase; TrEMBL-Plants: tr|I1KT56|I1KT56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0400300 | 13 | ||
| – | Aminotransferase; TAIR: AT2G22250.2 aspartate aminotransferase; Swiss-Prot: sp|E9L7A5|PAT_PETHY Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase; TrEMBL-Plants: tr|I1KT56|I1KT56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0400300 | 18 | ||
| – | Aminotransferase; TAIR: AT2G22250.2 aspartate aminotransferase; Swiss-Prot: sp|E9L7A5|PAT_PETHY Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase; TrEMBL-Plants: tr|I1KT56|I1KT56_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0400300 | 13 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase; TAIR: AT4G11280.1 1-aminocyclopropane-1-carboxylic acid (acc) synthase 6; Swiss-Prot: sp|P31531|1A1C_SOYBN 1-aminocyclopropane-1-carboxylate synthase; TrEMBL-Plants: tr|A0A1J7GH20|A0A1J7GH20_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0430100 | 15 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase; TAIR: AT4G11280.1 1-aminocyclopropane-1-carboxylic acid (acc) synthase 6; Swiss-Prot: sp|P31531|1A1C_SOYBN 1-aminocyclopropane-1-carboxylate synthase; TrEMBL-Plants: tr|A0A0B2NS63|A0A0B2NS63_GLYSO 1-aminocyclopropane-1-carboxylate synthase; Found in the gene: LotjaGi4g1v0430100 | 15 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase; TAIR: AT4G11280.1 1-aminocyclopropane-1-carboxylic acid (acc) synthase 6; Swiss-Prot: sp|P31531|1A1C_SOYBN 1-aminocyclopropane-1-carboxylate synthase; TrEMBL-Plants: tr|A0A1J7GH20|A0A1J7GH20_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0430100 | 15 | ||
| – | 1-aminocyclopropane-1-carboxylate synthase; TAIR: AT4G26200.1 1-amino-cyclopropane-1-carboxylate synthase 7; Swiss-Prot: sp|Q9STR4|1A17_ARATH 1-aminocyclopropane-1-carboxylate synthase 7; TrEMBL-Plants: tr|I1KJU2|I1KJU2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0441500 | 14 | ||
| – | Aspartate aminotransferase; TAIR: AT4G31990.1 aspartate aminotransferase 5; Swiss-Prot: sp|P26563|AATM_LUPAN Aspartate aminotransferase P2, mitochondrial; TrEMBL-Plants: tr|O22618|O22618_LOTCO Aspartate aminotransferase; Found in the gene: LotjaGi5g1v0056100 | 17 | ||
| – | Aspartate aminotransferase; TAIR: AT4G31990.1 aspartate aminotransferase 5; Swiss-Prot: sp|P26563|AATM_LUPAN Aspartate aminotransferase P2, mitochondrial; TrEMBL-Plants: tr|O22618|O22618_LOTCO Aspartate aminotransferase; Found in the gene: LotjaGi5g1v0056100 | 17 | ||
| – | Aspartate aminotransferase; TAIR: AT4G31990.1 aspartate aminotransferase 5; Swiss-Prot: sp|P26563|AATM_LUPAN Aspartate aminotransferase P2, mitochondrial; TrEMBL-Plants: tr|O22618|O22618_LOTCO Aspartate aminotransferase; Found in the gene: LotjaGi5g1v0056100 | 15 | ||
| – | Aspartate aminotransferase; TAIR: AT4G31990.1 aspartate aminotransferase 5; Swiss-Prot: sp|P26563|AATM_LUPAN Aspartate aminotransferase P2, mitochondrial; TrEMBL-Plants: tr|O22618|O22618_LOTCO Aspartate aminotransferase; Found in the gene: LotjaGi5g1v0056100 | 15 | ||
| – | Aspartate aminotransferase; TAIR: AT4G31990.1 aspartate aminotransferase 5; Swiss-Prot: sp|P26563|AATM_LUPAN Aspartate aminotransferase P2, mitochondrial; TrEMBL-Plants: tr|O22618|O22618_LOTCO Aspartate aminotransferase; Found in the gene: LotjaGi5g1v0056100 | 15 | ||
| – | Aspartate aminotransferase; TAIR: AT4G31990.1 aspartate aminotransferase 5; Swiss-Prot: sp|P26563|AATM_LUPAN Aspartate aminotransferase P2, mitochondrial; TrEMBL-Plants: tr|O22618|O22618_LOTCO Aspartate aminotransferase; Found in the gene: LotjaGi5g1v0056100 | 15 | ||
| – | Aminotransferase; TAIR: AT1G77670.1 Pyridoxal phosphate (PLP)-dependent transferases superfamily protein; Swiss-Prot: sp|Q16773|KAT1_HUMAN Kynurenine--oxoglutarate transaminase 1; TrEMBL-Plants: tr|I1JBI5|I1JBI5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0247400 | 13 | ||
| – | Aminotransferase; TAIR: AT2G22250.1 aspartate aminotransferase; Swiss-Prot: sp|E9L7A5|PAT_PETHY Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase; TrEMBL-Plants: tr|A0A151U932|A0A151U932_CAJCA Aspartate aminotransferase; Found in the gene: LotjaGi6g1v0085500 | 13 | ||
| – | Aminotransferase; TAIR: AT2G22250.1 aspartate aminotransferase; Swiss-Prot: sp|E9L7A5|PAT_PETHY Bifunctional aspartate aminotransferase and glutamate/aspartate-prephenate aminotransferase; TrEMBL-Plants: tr|I1LN02|I1LN02_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0085500 | 13 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd00609 | CDD | 1 | 1.54 |