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IPR008395

Description

IPR008395 is a Agenet-like domain.

<p>Fragile X messenger ribonucleoprotein 1 (FMR1/FMRP), and its autosomal paralogues, RNA-binding proteins FXR1/2 (Fragile X-related protein 1/2), comprise a family of RNA-binding proteins that are involved the regulation of alternative mRNA splicing, mRNA stability, mRNA dendritic transport and postsynaptic local protein synthesis of a subset of mRNAs, playing a crucial role in neuronal development and synaptic plasticity [[cite:PUB00054919], [cite:PUB00090595], [cite:PUB00090596], [cite:PUB00091337], [cite:PUB00091115]]. These proteins are highly similar to one another and also retain highly conserved domain architecture. The three ribonucleoprotein K homology (KH) domains and the cluster of arginine and glycine residues that constitute the RGG box, comprise a large region that is important for RNA binding and polyribosome association [[cite:PUB00091115]]. In addition, two Agenet-like domains exist in tandem within the N-terminal regions of FMRP family proteins. The Agenet-like domain belongs to the "Royal" domain superfamily which contains also the Tudor, chromo, MBT, PWWP and plant Agenet domains. Biochemical analysis of the tandem Agenet-like domains reveals their ability to preferentially recognise trimethylated peptides in a sequence-specific manner [[cite:PUB00011247], [cite:PUB00060514], [cite:PUB00039656], [cite:PUB00060515]].</p> <p>The Tudor/Agenet-like domain folds into a bent four-stranded antiparallel β-sheet with a fifth strand closing the cavity of the sheet, similar to a thumb across a semiclosed hand [[cite:PUB00039656], [cite:PUB00060515]]. This domain is also found plant proteins, such as AGDP1 from Arabidopsis, which is required for transcriptional silencing, non-CG DNA methylation and H3K9 dimethylation (H3K9me2) at some loci [[cite:PUB00103107], [cite:PUB00103108]]. It preferentially occupies long transposons and specifically recognizes the histone H3 'Lys-9' methylation (H3K9me) marks, with a stronger affinity for dimethylated H3K9 (H3K9me2) [[cite:PUB00103107], [cite:PUB00103108]]. Plant DUF724 domain-containing proteins are also members of this entry, and they may be involved in the polar growth of plant cells via transportation of RNAs [[cite:PUB00086467]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 77

Transcript Name Description Predicted domains Domain count
RNA binding protein [Medicago truncatula] gi|357479531|ref|XP_003610051.1| 6
RNA binding protein [Medicago truncatula] gi|357479531|ref|XP_003610051.1| 6
RNA binding protein [Medicago truncatula] gi|357437873|ref|XP_003589212.1| 5
Agenet domain-containing protein / bromo-adjacent homology (BAH) domain-containing protein [Arabidopsis thaliana] gi|22327858|ref|NP_200371.2| 10
Plant Tudor-like protein [Arabidopsis thaliana] gi|15221452|ref|NP_172123.1| 2
RNA binding protein [Medicago truncatula] gi|357479531|ref|XP_003610051.1| 6
Agenet domain-containing protein / bromo-adjacent homology (BAH) domain-containing protein [Arabidopsis thaliana] gi|22327858|ref|NP_200371.2| 9
Chromodomain helicase-DNA-binding protein [Medicago truncatula] gi|357490843|ref|XP_003615709.1| 7
Chromodomain helicase-DNA-binding protein [Medicago truncatula] gi|357490843|ref|XP_003615709.1| 7
RNA binding protein [Medicago truncatula] gi|357479531|ref|XP_003610051.1| 5
RNA binding protein [Medicago truncatula] gi|357448811|ref|XP_003594681.1| 5
Agenet domain-containing protein [Arabidopsis thaliana] gi|15230734|ref|NP_187304.1| 5
RNA binding protein [Medicago truncatula] gi|357479531|ref|XP_003610051.1| 5
RNA binding protein [Medicago truncatula] gi|357479531|ref|XP_003610051.1| 5
RNA binding protein [Medicago truncatula] gi|357466301|ref|XP_003603435.1| 6
RNA binding protein [Medicago truncatula] gi|357466301|ref|XP_003603435.1| 6
RNA binding protein [Medicago truncatula] gi|357466301|ref|XP_003603435.1| 6
RNA binding protein [Medicago truncatula] gi|357466301|ref|XP_003603435.1| 6
Agenet domain-containing protein [Arabidopsis lyrata subsp]. lyrata] gi|297849236|ref|XP_002892499.1| 7
RNA binding protein [Zea mays] gi|226508782|ref|NP_001151949.1| 6
Agenet domain-containing protein [Arabidopsis lyrata subsp]. lyrata] gi|297849236|ref|XP_002892499.1| 5
Agenet and bromo-adjacent homology (BAH) domain-containing protein-like protein [Medicago truncatula] gi|357488501|ref|XP_003614538.1| 11
PREDICTED: serine-rich adhesin for platelets-like isoform X4 [Cicer arietinum] gi|502160284|ref|XP_004511695.1| 8
Agenet domain containing protein expressed [Medicago truncatula] gi|357482073|ref|XP_003611322.1| 8
Agenet domain containing protein expressed [Medicago truncatula] gi|357482073|ref|XP_003611322.1| 8
RNA binding protein [Medicago truncatula] gi|357479531|ref|XP_003610051.1| 6
RNA binding protein [Medicago truncatula] gi|357477933|ref|XP_003609252.1| 8
T31J12.4 [Arabidopsis thaliana] gi|4337176|gb|AAD18097.1| 6
T31J12.4 [Arabidopsis thaliana] gi|4337176|gb|AAD18097.1| 6
Agenet domain-containing protein / bromo-adjacent homology (BAH) domain-containing protein [Arabidopsis thaliana] gi|22327858|ref|NP_200371.2| 4
Agenet domain-containing protein [Arabidopsis thaliana] gi|42561856|ref|NP_172403.3| 5
Agenet domain-containing protein [Arabidopsis thaliana] gi|42561856|ref|NP_172403.3| 5
Agenet domain-containing protein / bromo-adjacent homology (BAH) domain-containing protein [Arabidopsis thaliana] gi|22327858|ref|NP_200371.2| 11
Agenet domain-containing protein / bromo-adjacent homology (BAH) domain-containing protein [Arabidopsis thaliana] gi|22327858|ref|NP_200371.2| 12
Agenet domain-containing protein / bromo-adjacent homology (BAH) domain-containing protein [Arabidopsis thaliana] gi|22327858|ref|NP_200371.2| 7
Agenet domain-containing protein [Arabidopsis lyrata subsp]. lyrata] gi|297849236|ref|XP_002892499.1| 5
Agenet domain protein; TAIR: AT1G06340.1 Plant Tudor-like protein; Swiss-Prot: sp|F4I8W1|DUF2_ARATH DUF724 domain-containing protein 2; TrEMBL-Plants: tr|I1KEN6|I1KEN6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi0g1v0000600 6
Agenet domain protein; TAIR: AT1G06340.1 Plant Tudor-like protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|I1KEN6|I1KEN6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi0g1v0000700 6
Agenet domain protein; TAIR: AT1G06340.1 Plant Tudor-like protein; Swiss-Prot: sp|F4I8W1|DUF2_ARATH DUF724 domain-containing protein 2; TrEMBL-Plants: tr|I1KEN6|I1KEN6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi0g1v0000800 7
RING/FYVE/PHD zinc finger protein; TAIR: AT5G58610.4 PHD finger transcription factor; Swiss-Prot: sp|F4IXE7|IDM1_ARATH Increased DNA methylation 1; TrEMBL-Plants: tr|G7JZJ8|G7JZJ8_MEDTR PHD zinc finger protein; Found in the gene: LotjaGi1g1v0118400_LC 26
Plant tudor-like RNA-binding protein; TAIR: AT4G32440.1 Plant Tudor-like RNA-binding protein; Swiss-Prot: sp|Q08A72|EML4_ARATH Protein EMSY-LIKE 4; TrEMBL-Plants: tr|I1JUF7|I1JUF7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0386200 13
Agenet domain protein; TAIR: AT4G32440.1 Plant Tudor-like RNA-binding protein; Swiss-Prot: sp|O22897|DUF6_ARATH DUF724 domain-containing protein 6; TrEMBL-Plants: tr|I1JUF8|I1JUF8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0386200 6
Agenet domain protein; TAIR: AT4G32440.1 Plant Tudor-like RNA-binding protein; Swiss-Prot: sp|O22897|DUF6_ARATH DUF724 domain-containing protein 6; TrEMBL-Plants: tr|I1JUF8|I1JUF8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0386200 6
Plant tudor-like RNA-binding protein; TAIR: AT4G32440.1 Plant Tudor-like RNA-binding protein; Swiss-Prot: sp|Q08A72|EML4_ARATH Protein EMSY-LIKE 4; TrEMBL-Plants: tr|I1JUF7|I1JUF7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0386200 13
Agenet domain protein; TAIR: AT1G09320.1 agenet domain-containing protein; Swiss-Prot: sp|Q8H0V4|DUF7_ARATH DUF724 domain-containing protein 7; TrEMBL-Plants: tr|A0A1J7H2H3|A0A1J7H2H3_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0674600_LC 6
Agenet domain-containing protein; TAIR: AT1G09320.1 agenet domain-containing protein; Swiss-Prot: sp|O22897|DUF6_ARATH DUF724 domain-containing protein 6; TrEMBL-Plants: tr|V4TB28|V4TB28_9ROSI Uncharacterized protein; Found in the gene: LotjaGi2g1v0188800_LC 6
Agenet domain-containing protein / bromo-adjacent domain-containing protein, putative; TAIR: AT1G68580.2 Agenet and bromo-adjacent homology (BAH) domain-containing protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|K7K2M6|K7K2M6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0278400 13
Agenet domain protein; TAIR: AT4G17330.3 G2484-1 protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|G7JXC3|G7JXC3_MEDTR Agenet domain protein; Found in the gene: LotjaGi2g1v0422300_LC 8
Agenet domain protein; TAIR: AT1G06340.1 Plant Tudor-like protein; Swiss-Prot: sp|Q8H0V4|DUF7_ARATH DUF724 domain-containing protein 7; TrEMBL-Plants: tr|I1KEN6|I1KEN6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0248700 6
Agenet domain protein; TAIR: AT1G06340.1 Plant Tudor-like protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|I1KEN6|I1KEN6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0249000 6
Agenet domain protein; TAIR: AT1G06340.1 Plant Tudor-like protein; Swiss-Prot: sp|F4I8W1|DUF2_ARATH DUF724 domain-containing protein 2; TrEMBL-Plants: tr|V7AJ16|V7AJ16_PHAVU Uncharacterized protein; Found in the gene: LotjaGi3g1v0249800 7
Agenet domain protein; TAIR: AT1G06340.1 Plant Tudor-like protein; Swiss-Prot: sp|F4I8W1|DUF2_ARATH DUF724 domain-containing protein 2; TrEMBL-Plants: tr|G7KCV4|G7KCV4_MEDTR Agenet domain protein; Found in the gene: LotjaGi3g1v0250100 6
Agenet domain protein; TAIR: AT5G42670.1 Agenet domain-containing protein; Swiss-Prot: sp|Q8H0V4|DUF7_ARATH DUF724 domain-containing protein 7; TrEMBL-Plants: tr|K7LS74|K7LS74_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0557900 6
Agenet domain protein; TAIR: AT4G17330.1 G2484-1 protein; Swiss-Prot: sp|Q9ZVT1|DUF1_ARATH DUF724 domain-containing protein 1; TrEMBL-Plants: tr|K7KN46|K7KN46_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0202100 7
Agenet domain protein; TAIR: AT4G17330.1 G2484-1 protein; Swiss-Prot: sp|Q9ZVT1|DUF1_ARATH DUF724 domain-containing protein 1; TrEMBL-Plants: tr|K7KN46|K7KN46_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0202100 7
Plant tudor-like RNA-binding protein; TAIR: AT4G32440.1 Plant Tudor-like RNA-binding protein; Swiss-Prot: sp|Q9C7C4|EML1_ARATH Protein EMSY-LIKE 1; TrEMBL-Plants: tr|K7ML77|K7ML77_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0267300 13
Plant tudor-like RNA-binding protein; TAIR: AT4G32440.1 Plant Tudor-like RNA-binding protein; Swiss-Prot: sp|Q9C7C4|EML1_ARATH Protein EMSY-LIKE 1; TrEMBL-Plants: tr|K7ML77|K7ML77_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0267300 13
Agenet domain-containing family protein; TAIR: AT4G32440.1 Plant Tudor-like RNA-binding protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|K7ML77|K7ML77_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0267300 6
Plant tudor-like RNA-binding protein; TAIR: AT4G32440.1 Plant Tudor-like RNA-binding protein; Swiss-Prot: sp|Q9C7C4|EML1_ARATH Protein EMSY-LIKE 1; TrEMBL-Plants: tr|K7ML77|K7ML77_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0267300 13
Plant tudor-like RNA-binding protein; TAIR: AT4G32440.1 Plant Tudor-like RNA-binding protein; Swiss-Prot: sp|Q9C7C4|EML1_ARATH Protein EMSY-LIKE 1; TrEMBL-Plants: tr|K7ML77|K7ML77_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0267300 13
Agenet domain-containing protein, putative; TAIR: AT1G09320.1 agenet domain-containing protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|A0A1J7GLB7|A0A1J7GLB7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0231900 6
Agenet domain-containing protein, putative; TAIR: AT1G09320.1 agenet domain-containing protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|A0A1J7GLB7|A0A1J7GLB7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0231900 6
Agenet domain-containing protein, putative; TAIR: AT1G09320.1 agenet domain-containing protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|A0A1J7GLB7|A0A1J7GLB7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0231900 6
Agenet domain-containing protein, putative; TAIR: AT1G09320.1 agenet domain-containing protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|A0A1J7GLB7|A0A1J7GLB7_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0231900 6
Agenet domain-containing protein, putative; TAIR: AT1G09320.1 agenet domain-containing protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|A0A1J7H2I0|A0A1J7H2I0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0338600 7
Agenet domain-containing protein, putative; TAIR: AT1G09320.1 agenet domain-containing protein; Swiss-Prot: sp|Q9ZVT1|DUF1_ARATH DUF724 domain-containing protein 1; TrEMBL-Plants: tr|M5W1D4|M5W1D4_PRUPE Uncharacterized protein; Found in the gene: LotjaGi5g1v0338800_LC 7
RING/FYVE/PHD zinc finger protein; TAIR: AT5G58610.3 PHD finger transcription factor; Swiss-Prot: sp|F4IXE7|IDM1_ARATH Increased DNA methylation 1; TrEMBL-Plants: tr|A0A1J7H9H6|A0A1J7H9H6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0122700_LC 27
RING/FYVE/PHD zinc finger protein; TAIR: AT5G58610.4 PHD finger transcription factor; Swiss-Prot: sp|F4IXE7|IDM1_ARATH Increased DNA methylation 1; TrEMBL-Plants: tr|A0A1J7H9H6|A0A1J7H9H6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0122700_LC 27
RING/FYVE/PHD zinc finger protein; TAIR: AT5G58610.4 PHD finger transcription factor; Swiss-Prot: sp|F4IXE7|IDM1_ARATH Increased DNA methylation 1; TrEMBL-Plants: tr|A0A1J7H9H6|A0A1J7H9H6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0122700_LC 28
PHD zinc finger protein; TAIR: AT5G58610.1 PHD finger transcription factor; Swiss-Prot: sp|F4IXE7|IDM1_ARATH Increased DNA methylation 1; TrEMBL-Plants: tr|I1LLM4|I1LLM4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0122700_LC 13
PHD zinc finger protein; TAIR: AT5G58610.3 PHD finger transcription factor; Swiss-Prot: sp|F4IXE7|IDM1_ARATH Increased DNA methylation 1; TrEMBL-Plants: tr|A0A1J7H9H6|A0A1J7H9H6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0122700_LC 13
Agenet domain-containing protein / bromo-adjacent domain-containing protein, putative; TAIR: AT5G55600.1 Agenet and bromo-adjacent homology (BAH) domain-containing protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|A0A0B2NVF2|A0A0B2NVF2_GLYSO Uncharacterized protein; Found in the gene: LotjaGi6g1v0144600 13
Agenet domain-containing protein / bromo-adjacent domain-containing protein, putative; TAIR: AT5G55600.1 Agenet and bromo-adjacent homology (BAH) domain-containing protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|K7MQK7|K7MQK7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0144800_LC 4
Agenet domain-containing protein; TAIR: AT3G06520.1 agenet domain-containing protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|A0A151T678|A0A151T678_CAJCA Uncharacterized protein; Found in the gene: LotjaGi6g1v0261900 6
Agenet domain-containing protein; TAIR: AT3G06520.1 agenet domain-containing protein; Swiss-Prot: sp|Q9FZD9|DUF3_ARATH DUF724 domain-containing protein 3; TrEMBL-Plants: tr|A0A151T678|A0A151T678_CAJCA Uncharacterized protein; Found in the gene: LotjaGi6g1v0261900 6
Agenet domain-containing protein / bromo-adjacent domain-containing protein, putative; TAIR: AT5G55600.1 Agenet and bromo-adjacent homology (BAH) domain-containing protein; Swiss-Prot: sp|F4I8W1|DUF2_ARATH DUF724 domain-containing protein 2; TrEMBL-Plants: tr|K7LB84|K7LB84_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0284100 13
Agenet domain-containing protein / bromo-adjacent domain-containing protein, putative; TAIR: AT5G55600.1 Agenet and bromo-adjacent homology (BAH) domain-containing protein; Swiss-Prot: sp|F4I8W1|DUF2_ARATH DUF724 domain-containing protein 2; TrEMBL-Plants: tr|K7LB84|K7LB84_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0284100 13

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 1.30