Description

IPR029016 is a GAF-like domain superfamily.

<p>This superfamily represents the GAF domain and domains sharing protein structural similarity, such as the C-terminal domain of the transcription regulator IclR, the C-terminal domain of the heat-inducible transcription repressor HrcA, and the phytochrome chromophore attachment domain.</p> <p>The GAF domain is named after some of the proteins it is found in, including cGMP-specific phosphodiesterases, adenylyl cyclases and FhlA. It is also found in guanylyl cyclases and phytochromes [[cite:PUB00005474], [cite:PUB00057240]]. The structure of a GAF domain shows that the domain shares a similar fold with the PAS domain [[cite:PUB00021559]]. Adenylyl and guanylyl cyclases catalyse ATP and GTP to the second messengers cAMP and cGMP respectively; these products up-regulate catalytic activity by binding to the regulatory GAF domain(s). The opposite hydrolysis reaction is catalysed by phosphodiesterase. cGMP-dependent 3',5'-cyclic phosphodiesterase catalyses the conversion of guanosine 3',5'-cyclic phosphate to guanosine 5'-phosphate. Here too, cGMP regulates catalytic activity by GAF-domain binding.</p> <p>Phytochromes are regulatory photoreceptors in plants and bacteria which exist in two thermally stable states that are reversibly inter-convertible by light, the Pr state absorbs maximally in the red region of the spectrum, while the Pfr state absorbs maximally in the far-red region [[cite:PUB00057239]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 36

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: