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GO:0004525

View this GO term in other databases

Overview

Field Value
Namespace Molecular function
Short description Ribonuclease III activity
Full defintion Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt.
Subterm of

Relationships

The relationship of GO:0004525 with other GO terms.

Relationship type GO terms
Is a
Regulates n.a.
Part of n.a.
Positively regulates n.a.
Negatively regulates n.a.

Ancestor tree

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Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field Value
PMID
Single processing center models for human Dicer and bacterial RNase III.Zhang H, Kolb FA, Jaskiewicz L, Westhof E, Filipowicz W
Cell. 2004 Jul 9; 118 (1): 57–68.PMID: 15242644

Dicer is a multidomain ribonuclease that processes double-stranded RNAs (dsRNAs) to 21 nt small interfering RNAs (siRNAs) during RNA interference, and excises microRNAs from precursor hairpins. Dicer contains two domains related to the bacterial dsRNA-specific endonuclease, RNase III, which is known to function as a homodimer. Based on an X-ray structure of the Aquifex aeolicus RNase III, models of the enzyme interaction with dsRNA, and its cleavage at two composite catalytic centers, have been proposed. We have generated mutations in human Dicer and Escherichia coli RNase III residues implicated in the catalysis, and studied their effect on RNA processing. Our results indicate that both enzymes have only one processing center, containing two RNA cleavage sites and generating products with 2 nt 3' overhangs. Based on these and other data, we propose that Dicer functions through intramolecular dimerization of its two RNase III domains, assisted by the flanking RNA binding domains, PAZ and dsRBD.

Associated Lotus transcripts 38

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

Transcript Name Description GO terms GO count
Lj0g3v0041629.1
– PREDICTED: dicer-like protein 4-like [Glycine max] gi|356565129|ref|XP_003550797.1|
GO terms
2
Lj0g3v0041629.2
– PREDICTED: dicer-like protein 4-like [Glycine max] gi|356565129|ref|XP_003550797.1|
GO terms
2
Lj0g3v0060749.1
– PREDICTED: mini-ribonuclease 3-like isoform X2 [Cicer arietinum] gi|502081294|ref|XP_004486823.1|
GO terms
2
Lj0g3v0186219.1
– Ribonuclease III family protein [Theobroma cacao] gi|508699738|gb|EOX91634.1|
GO terms
2
Lj1g3v1788430.1
– PREDICTED: LOW QUALITY PROTEIN: endoribonuclease Dicer homolog 3a-like [Cicer arietinum] gi|502132552|ref|XP_004501416.1|
GO terms
2
Lj1g3v5034650.1
– PREDICTED: endoribonuclease Dicer homolog 2-like [Glycine max] gi|356571230|ref|XP_003553782.1|
GO terms
2
Lj2g3v0866690.1
– PREDICTED: LOW QUALITY PROTEIN: endoribonuclease Dicer homolog 3a-like [Cicer arietinum] gi|502132552|ref|XP_004501416.1|
GO terms
2
Lj2g3v1963040.1
– Ribonuclease [Medicago truncatula] gi|357453661|ref|XP_003597111.1|
GO terms
2
Lj2g3v3188380.1
– PREDICTED: ribonuclease 3-like protein 2-like [Cicer arietinum] gi|502099207|ref|XP_004491416.1|
GO terms
2
Lj3g3v0306890.1
– PREDICTED: mini-ribonuclease 3-like isoform X2 [Cicer arietinum] gi|502081294|ref|XP_004486823.1|
GO terms
2
Lj4g3v1535060.1
– Ribonuclease [Medicago truncatula] gi|357477313|ref|XP_003608942.1|
GO terms
2
Lj5g3v0962640.1
– PREDICTED: ribonuclease 3-like protein 2-like [Cicer arietinum] gi|502099207|ref|XP_004491416.1|
GO terms
2
Lj6g3v1629840.1
– PREDICTED: endoribonuclease Dicer homolog 2-like [Glycine max] gi|356533095|ref|XP_003535104.1|
GO terms
2
Lj6g3v1629870.1
– PREDICTED: endoribonuclease Dicer homolog 2-like [Glycine max] gi|356532427|ref|XP_003534774.1|
GO terms
2
Lj6g3v1629940.1
– PREDICTED: endoribonuclease Dicer homolog 2-like [Glycine max] gi|356532427|ref|XP_003534774.1|
GO terms
2
LotjaGi1g1v0026400.1
– Ribonuclease 3-like protein 3; TAIR: AT3G20420.1 RNAse THREE-like protein 2; Swiss-Prot: sp|Q9LTQ0|RTL2_ARATH Ribonuclease 3-like protein 2; TrEMBL-Plants: tr|A0A1J7IPZ1|A0A1J7IPZ1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0026400
GO terms
2
LotjaGi1g1v0372300.1
– Dicer-like protein 3; TAIR: AT3G43920.2 dicer-like 3; Swiss-Prot: sp|Q5N870|DCL3A_ORYSJ Endoribonuclease Dicer homolog 3a; TrEMBL-Plants: tr|K7KIB7|K7KIB7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0372300
GO terms
2
LotjaGi1g1v0791500.1
– Ribonuclease 3-like protein 3; TAIR: AT3G03300.1 dicer-like 2; Swiss-Prot: sp|Q3EBC8|DCL2_ARATH Endoribonuclease Dicer homolog 2; TrEMBL-Plants: tr|A0A151TUM2|A0A151TUM2_CAJCA Endoribonuclease Dicer isogeny 2a; Found in the gene: LotjaGi1g1v0791500
GO terms
2
LotjaGi1g1v0798000.1
– Endoribonuclease Dicer-like protein 3; TAIR: AT1G01040.1 dicer-like 1; Swiss-Prot: sp|Q9SP32|DCL1_ARATH Endoribonuclease Dicer homolog 1; TrEMBL-Plants: tr|K7N0F5|K7N0F5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0798000
GO terms
2
LotjaGi1g1v0798000.2
– Ribonuclease 3-like protein 3; TAIR: AT1G01040.1 dicer-like 1; Swiss-Prot: sp|Q9SP32|DCL1_ARATH Endoribonuclease Dicer homolog 1; TrEMBL-Plants: tr|A0A072U4N5|A0A072U4N5_MEDTR Endoribonuclease dicer-like protein; Found in the gene: LotjaGi1g1v0798000
GO terms
2
LotjaGi1g1v0798000.3
– Ribonuclease 3-like protein 3; TAIR: AT1G01040.1 dicer-like 1; Swiss-Prot: sp|Q9SP32|DCL1_ARATH Endoribonuclease Dicer homolog 1; TrEMBL-Plants: tr|A0A072U4N5|A0A072U4N5_MEDTR Endoribonuclease dicer-like protein; Found in the gene: LotjaGi1g1v0798000
GO terms
2
LotjaGi1g1v0798000.4
– Endoribonuclease Dicer-like protein 3; TAIR: AT1G01040.1 dicer-like 1; Swiss-Prot: sp|Q9SP32|DCL1_ARATH Endoribonuclease Dicer homolog 1; TrEMBL-Plants: tr|K7N0F5|K7N0F5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0798000
GO terms
2
LotjaGi1g1v0798000.5
– Endoribonuclease Dicer-like protein 3; TAIR: AT1G01040.1 dicer-like 1; Swiss-Prot: sp|Q9SP32|DCL1_ARATH Endoribonuclease Dicer homolog 1; TrEMBL-Plants: tr|K7N0F5|K7N0F5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0798000
GO terms
2
LotjaGi2g1v0407000.3
– Ribonuclease 3; TAIR: AT4G37510.1 Ribonuclease III family protein; Swiss-Prot: sp|Q9SZV0|RNC1_ARATH Ribonuclease III domain-containing protein RNC1, chloroplastic; TrEMBL-Plants: tr|A0A151SCA9|A0A151SCA9_CAJCA Ribonuclease 3; Found in the gene: LotjaGi2g1v0407000
GO terms
2
LotjaGi2g1v0407000.5
– Ribonuclease 3; TAIR: AT4G37510.1 Ribonuclease III family protein; Swiss-Prot: sp|Q9SZV0|RNC1_ARATH Ribonuclease III domain-containing protein RNC1, chloroplastic; TrEMBL-Plants: tr|A0A151SCA9|A0A151SCA9_CAJCA Ribonuclease 3; Found in the gene: LotjaGi2g1v0407000
GO terms
2
LotjaGi3g1v0025300.1
– Mini-ribonuclease 3; TAIR: AT1G55140.1 Ribonuclease III family protein; Swiss-Prot: sp|P74327|MRNC_SYNY3 Mini-ribonuclease 3; TrEMBL-Plants: tr|A0A0S3SFS1|A0A0S3SFS1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0025300
GO terms
2
LotjaGi4g1v0097200.1
– Ribonuclease 3; TAIR: AT4G37510.1 Ribonuclease III family protein; Swiss-Prot: sp|Q9SZV0|RNC1_ARATH Ribonuclease III domain-containing protein RNC1, chloroplastic; TrEMBL-Plants: tr|A0A0S3R594|A0A0S3R594_PHAAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0097200
GO terms
2
LotjaGi4g1v0097200.2
– Ribonuclease 3; TAIR: AT4G37510.1 Ribonuclease III family protein; Swiss-Prot: sp|A6YSL1|RNC1_MAIZE Ribonuclease III domain-containing protein RNC1, chloroplastic; TrEMBL-Plants: tr|G7JCT8|G7JCT8_MEDTR Ribonuclease III domain protein; Found in the gene: LotjaGi4g1v0097200
GO terms
2
LotjaGi4g1v0239100.1
– Ribonuclease 3; TAIR: AT1G24450.1 Ribonuclease III family protein; Swiss-Prot: sp|Q9FYL8|NFD2_ARATH Protein NUCLEAR FUSION DEFECTIVE 2; TrEMBL-Plants: tr|I3T487|I3T487_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0239100
GO terms
2
LotjaGi4g1v0239400.1
– Ribonuclease 3; TAIR: AT1G24450.1 Ribonuclease III family protein; Swiss-Prot: sp|Q9FYL8|NFD2_ARATH Protein NUCLEAR FUSION DEFECTIVE 2; TrEMBL-Plants: tr|I3T487|I3T487_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0239400
GO terms
2
LotjaGi4g1v0239400.2
– Ribonuclease 3; TAIR: AT1G24450.1 Ribonuclease III family protein; Swiss-Prot: sp|Q9FYL8|NFD2_ARATH Protein NUCLEAR FUSION DEFECTIVE 2; TrEMBL-Plants: tr|I3T487|I3T487_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0239400
GO terms
2
LotjaGi4g1v0239400.3
– Ribonuclease 3; TAIR: AT1G24450.1 Ribonuclease III family protein; Swiss-Prot: sp|Q9FYL8|NFD2_ARATH Protein NUCLEAR FUSION DEFECTIVE 2; TrEMBL-Plants: tr|I3T487|I3T487_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0239400
GO terms
2
LotjaGi4g1v0283700.1
– Dicer-like 3; TAIR: AT5G20320.1 dicer-like 4; Swiss-Prot: sp|P84634|DCL4_ARATH Dicer-like protein 4; TrEMBL-Plants: tr|K7MKZ2|K7MKZ2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0283700
GO terms
2
LotjaGi5g1v0164100.1
– Ribonuclease 3-like protein 3; TAIR: AT3G20420.1 RNAse THREE-like protein 2; Swiss-Prot: sp|Q9LTQ0|RTL2_ARATH Ribonuclease 3-like protein 2; TrEMBL-Plants: tr|A0A1J7IPZ1|A0A1J7IPZ1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0164100
GO terms
2
LotjaGi5g1v0164100.2
– Ribonuclease 3-like protein 3; TAIR: AT3G20420.1 RNAse THREE-like protein 2; Swiss-Prot: sp|Q9LTQ0|RTL2_ARATH Ribonuclease 3-like protein 2; TrEMBL-Plants: tr|A0A1J7IPZ1|A0A1J7IPZ1_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0164100
GO terms
2
LotjaGi6g1v0269600.1
– Endoribonuclease Dicer-like protein 3; TAIR: AT3G03300.1 dicer-like 2; Swiss-Prot: sp|Q3EBC8|DCL2_ARATH Endoribonuclease Dicer homolog 2; TrEMBL-Plants: tr|I1L0G0|I1L0G0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0269600
GO terms
2
LotjaGi6g1v0269600.2
– Endoribonuclease Dicer-like protein 3; TAIR: AT3G03300.1 dicer-like 2; Swiss-Prot: sp|Q3EBC8|DCL2_ARATH Endoribonuclease Dicer homolog 2; TrEMBL-Plants: tr|I1L0G0|I1L0G0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0269600
GO terms
2
LotjaGi6g1v0269800_LC.1
– Ribonuclease 3-like protein 3; TAIR: AT3G03300.4 dicer-like 2; Swiss-Prot: sp|Q3EBC8|DCL2_ARATH Endoribonuclease Dicer homolog 2; TrEMBL-Plants: tr|A0A1J7HMM6|A0A1J7HMM6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0269800_LC
GO terms
2

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space:

GO term Namespace Name Observations Saturation (%)
GO:0006396
Biological process RNA processing 1 2.63