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IPR039417 is a Papain-like cysteine endopeptidase.
<p>This entry represents homologues of papain, from peptidase family C1 subfamily A, including the mammalian CPs (cathepsins F, H, L, K, O, S, V, X and W) [[cite:PUB00011704]]. Cathepsins B and C, which differ in their activation peptides, are not included here [[cite:PUB00089613]]. Papain is an endopeptidase with specific substrate preferences, primarily for bulky hydrophobic or aromatic residues at the S2 subsite, a hydrophobic pocket in papain that accommodates the P2 sidechain of the substrate (the second residue away from the scissile bond). Most members of the papain subfamily are endopeptidases. Some exceptions to this rule can be explained by specific details of the catalytic domains like the occluding loop in cathepsin B which confers an additional peptidyl-dipeptidase activity and the mini-chain of cathepsin H resulting in an N-terminal exopeptidase activity [[cite:PUB00089615]].</p>
This description is obtained from EB-eye REST.
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Cysteine proteinase; TAIR: AT5G50260.1 Cysteine proteinases superfamily protein; Swiss-Prot: sp|P25803|CYSEP_PHAVU Vignain; TrEMBL-Plants: tr|I1KC88|I1KC88_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0230500 | 27 | ||
– | Cysteine proteinase; TAIR: AT5G43060.1 Granulin repeat cysteine protease family protein; Swiss-Prot: sp|Q9FMH8|RD21B_ARATH Probable cysteine protease RD21B; TrEMBL-Plants: tr|I1M8Q5|I1M8Q5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0357600 | 21 | ||
– | Cysteine proteinase; TAIR: AT4G35350.1 xylem cysteine peptidase 1; Swiss-Prot: sp|O65493|XCP1_ARATH Cysteine protease XCP1; TrEMBL-Plants: tr|G8A0A3|G8A0A3_MEDTR Papain family cysteine protease; Found in the gene: LotjaGi1g1v0411800 | 11 | ||
– | Cysteine protease; TAIR: AT4G23520.1 Cysteine proteinases superfamily protein; Swiss-Prot: sp|F4JNL3|RDL6_ARATH Probable cysteine protease RDL6; TrEMBL-Plants: tr|A0A0E0MEC8|A0A0E0MEC8_ORYPU Uncharacterized protein; Found in the gene: LotjaGi1g1v0420600_LC | 10 | ||
– | Cysteine protease family protein; TAIR: AT1G09850.1 xylem bark cysteine peptidase 3; Swiss-Prot: sp|Q9LT78|RD21C_ARATH Probable cysteine protease RD21C; TrEMBL-Plants: tr|A0A1J7IIQ9|A0A1J7IIQ9_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0423400 | 34 | ||
– | Cysteine proteinase; TAIR: AT4G39090.1 Papain family cysteine protease; Swiss-Prot: sp|P25804|CYSP_PEA Cysteine proteinase 15A; TrEMBL-Plants: tr|A0A151RQM7|A0A151RQM7_CAJCA Cysteine proteinase RD19a; Found in the gene: LotjaGi1g1v0424400 | 27 | ||
– | Cysteine proteinase; TAIR: AT4G35350.1 xylem cysteine peptidase 1; Swiss-Prot: sp|O65493|XCP1_ARATH Cysteine protease XCP1; TrEMBL-Plants: tr|I1K796|I1K796_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0569300 | 26 | ||
– | Cysteine protease; TAIR: AT1G06260.1 Cysteine proteinases superfamily protein; Swiss-Prot: sp|Q9FJ47|SAG12_ARATH Senescence-specific cysteine protease SAG12; TrEMBL-Plants: tr|A0A1J7H619|A0A1J7H619_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0245200 | 28 | ||
– | Cysteine protease; TAIR: AT1G06260.1 Cysteine proteinases superfamily protein; Swiss-Prot: sp|Q9FJ47|SAG12_ARATH Senescence-specific cysteine protease SAG12; TrEMBL-Plants: tr|G8A001|G8A001_MEDTR Papain family cysteine protease; Found in the gene: LotjaGi3g1v0245300 | 27 | ||
– | Cysteine protease; TAIR: AT5G45890.1 senescence-associated gene 12; Swiss-Prot: sp|A2XQE8|SAG39_ORYSI Senescence-specific cysteine protease SAG39; TrEMBL-Plants: tr|K7K0Y1|K7K0Y1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0248000 | 27 | ||
– | Cysteine protease, putative; TAIR: AT5G45890.1 senescence-associated gene 12; Swiss-Prot: sp|A2XQE8|SAG39_ORYSI Senescence-specific cysteine protease SAG39; TrEMBL-Plants: tr|K4MQ82|K4MQ82_LOTJA Cysteine proteinase; Found in the gene: LotjaGi3g1v0249300 | 27 | ||
– | Cysteine protease, putative; TAIR: AT5G45890.1 senescence-associated gene 12; Swiss-Prot: sp|A2XQE8|SAG39_ORYSI Senescence-specific cysteine protease SAG39; TrEMBL-Plants: tr|A4PIZ3|A4PIZ3_LOTJA Cysteine proteinase; Found in the gene: LotjaGi3g1v0254300 | 20 | ||
– | Cysteine protease; TAIR: AT5G45890.1 senescence-associated gene 12; Swiss-Prot: sp|A2XQE8|SAG39_ORYSI Senescence-specific cysteine protease SAG39; TrEMBL-Plants: tr|A4PIZ2|A4PIZ2_LOTJA Cysteine proteinase; Found in the gene: LotjaGi3g1v0489300 | 27 | ||
– | Cysteine protease, putative; TAIR: AT5G45890.1 senescence-associated gene 12; Swiss-Prot: sp|A2XQE8|SAG39_ORYSI Senescence-specific cysteine protease SAG39; TrEMBL-Plants: tr|A4PIZ2|A4PIZ2_LOTJA Cysteine proteinase; Found in the gene: LotjaGi3g1v0489400 | 26 | ||
– | Cysteine proteinase; TAIR: AT4G39090.1 Papain family cysteine protease; Swiss-Prot: sp|P43296|RD19A_ARATH Cysteine protease RD19A; TrEMBL-Plants: tr|B0BL96|B0BL96_LOTJA CM0216.510.nc protein; Found in the gene: LotjaGi3g1v0508700 | 27 | ||
– | Cysteine proteinase; TAIR: AT4G39090.1 Papain family cysteine protease; Swiss-Prot: sp|P43296|RD19A_ARATH Cysteine protease RD19A; TrEMBL-Plants: tr|Q70I35|Q70I35_LOTJA Papain-like cysteine proteinase-like protein 2; Found in the gene: LotjaGi3g1v0512500 | 26 | ||
– | Cysteine proteinase; TAIR: AT4G39090.1 Papain family cysteine protease; Swiss-Prot: sp|P43296|RD19A_ARATH Cysteine protease RD19A; TrEMBL-Plants: tr|B0BL95|B0BL95_LOTJA CM0216.500.nc protein; Found in the gene: LotjaGi3g1v0512700 | 26 | ||
– | Cysteine protease; TAIR: AT1G47128.1 Granulin repeat cysteine protease family protein; Swiss-Prot: sp|P43297|RD21A_ARATH Cysteine proteinase RD21A; TrEMBL-Plants: tr|I1K268|I1K268_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0101100 | 27 | ||
– | Cysteine proteinase; TAIR: AT5G50260.1 Cysteine proteinases superfamily protein; Swiss-Prot: sp|P25803|CYSEP_PHAVU Vignain; TrEMBL-Plants: tr|I1MUK9|I1MUK9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0226000 | 24 | ||
– | Cysteine protease, putative; TAIR: AT5G50260.1 Cysteine proteinases superfamily protein; Swiss-Prot: sp|P25803|CYSEP_PHAVU Vignain; TrEMBL-Plants: tr|A0A072UQV2|A0A072UQV2_MEDTR KDEL-tailed cysteine endopeptidase CEP1; Found in the gene: LotjaGi4g1v0226100 | 27 | ||
– | Cysteine protease; TAIR: AT3G45310.1 Cysteine proteinases superfamily protein; Swiss-Prot: sp|Q8RWQ9|ALEUL_ARATH Thiol protease aleurain-like; TrEMBL-Plants: tr|I3SZ47|I3SZ47_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0324600 | 27 | ||
– | Cysteine proteinase; TAIR: AT4G39090.1 Papain family cysteine protease; Swiss-Prot: sp|P25804|CYSP_PEA Cysteine proteinase 15A; TrEMBL-Plants: tr|K7MNZ5|K7MNZ5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0010700 | 14 | ||
– | Cysteine proteinase; TAIR: AT4G39090.1 Papain family cysteine protease; Swiss-Prot: sp|P25804|CYSP_PEA Cysteine proteinase 15A; TrEMBL-Plants: tr|I1MC68|I1MC68_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0010700 | 27 | ||
– | Cysteine proteinase; TAIR: AT1G47128.1 Granulin repeat cysteine protease family protein; Swiss-Prot: sp|P43297|RD21A_ARATH Cysteine proteinase RD21A; TrEMBL-Plants: tr|A0A1J7IKX0|A0A1J7IKX0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0030300 | 33 | ||
– | Cysteine proteinase; TAIR: AT3G54940.2 Papain family cysteine protease; Swiss-Prot: sp|Q8VYS0|RD19D_ARATH Probable cysteine protease RD19D; TrEMBL-Plants: tr|A0A072VPA6|A0A072VPA6_MEDTR Papain family cysteine protease; Found in the gene: LotjaGi5g1v0269900 | 25 | ||
– | Cysteine protease, putative; TAIR: AT5G43060.1 Granulin repeat cysteine protease family protein; Swiss-Prot: sp|Q9FMH8|RD21B_ARATH Probable cysteine protease RD21B; TrEMBL-Plants: tr|A0A1J7HJC8|A0A1J7HJC8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0329500 | 33 | ||
– | Cysteine protease; TAIR: AT1G09850.1 xylem bark cysteine peptidase 3; Swiss-Prot: sp|P25776|ORYA_ORYSJ Oryzain alpha chain; TrEMBL-Plants: tr|A0A151S6D2|A0A151S6D2_CAJCA Cysteine proteinase RD21a; Found in the gene: LotjaGi6g1v0322400 | 35 | ||
– | Cysteine protease; TAIR: AT1G20850.1 xylem cysteine peptidase 2; Swiss-Prot: sp|P22895|P34_SOYBN P34 probable thiol protease; TrEMBL-Plants: tr|G7ILJ3|G7ILJ3_MEDTR Papain family cysteine protease; Found in the gene: LotjaGi6g1v0323700 | 26 | ||
– | Cysteine protease; TAIR: AT3G49340.1 Cysteine proteinases superfamily protein; Swiss-Prot: sp|Q9FJ47|SAG12_ARATH Senescence-specific cysteine protease SAG12; TrEMBL-Plants: tr|I3S8V9|I3S8V9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0324000 | 26 | ||
– | Cysteine protease; TAIR: AT2G34080.1 Cysteine proteinases superfamily protein; Swiss-Prot: sp|Q9FJ47|SAG12_ARATH Senescence-specific cysteine protease SAG12; TrEMBL-Plants: tr|I3S8V9|I3S8V9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0324100 | 27 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 3.33 |