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IPR031468

Source: InterPro

Description

IPR031468 is a Synaptotagmin-like mitochondrial-lipid-binding domain.

<p>Membrane contacts sites (MCSs), regions where two organelles come in close proximity to one another, act as molecular hubs for the exchange of small molecules (e.g. lipids) and signals (e.g. calcium ions). Synaptotagmin-like Mitochondrial lipid-binding Proteins (SMP) domains are exclusively found at MCSs between different organelles such as endoplasmic reticulum (ER)- Mitochondrion, ER-Plasma membrane (PM) and Nucleus-Vacuole junctions. The SMP domain is able to homo- or heterodimerize, harbors lipids in a hydrophobic cavity and mediates lipid transfer between the two adjacent bilayers independently of membrane fusion and fission reactions. SMP proteins are widespread amongst eukaryotic species with a particular enrichment in plants and features suggestive of species-specific functional variations. SMP domain- containing proteins have been classified into four broad groups: C2 domain synaptotagmin-like, PH domain-containing HT-008, PDZK8 and mitochondrial protein families [[cite:PUB00075642], [cite:PUB00088664], [cite:PUB00087563], [cite:PUB00075878], [cite:PUB00088665], [cite:PUB00088666]].</p> <p>The SMP domain consists of 6 β-strands and 3 helices arranged to form a barrel whose interior is lined almost exclusively by hydrophobic residues. The resulting elongated barrel-shaped cylindrical structure harbors a lateral opening and a central hydrophobic cavity where phospholipids can bind. It dimerizes in an anti-parallel fashion to form a cylinder traversed by a deep hydrophobic groove [[cite:PUB00075878], [cite:PUB00088665], [cite:PUB00088666]]. The SMP domain belongs to the TULIP (for TUbular LIPid-binding) protein superfamily of lipid transfer proteins [[cite:PUB00088667]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0008289
Molecular function Lipid binding Interacting selectively and non-covalently with a lipid.
Subterm of

Associated Lotus transcripts 45

Transcript Name Description Predicted domains Domain count
Lj0g3v0075379.1
– PREDICTED: extended synaptotagmin-3-like [Glycine max] gi|356538638|ref|XP_003537808.1|
Domains
16
Lj0g3v0075379.3
– PREDICTED: extended synaptotagmin-3-like [Glycine max] gi|356538638|ref|XP_003537808.1|
Domains
8
Lj0g3v0105589.1
– PREDICTED: synaptotagmin-4-like isoform X2 [Cicer arietinum] gi|502104829|ref|XP_004492658.1|
Domains
18
Lj0g3v0105589.2
– PREDICTED: synaptotagmin-4-like isoform X2 [Cicer arietinum] gi|502104829|ref|XP_004492658.1|
Domains
16
Lj0g3v0266549.1
– PREDICTED: tricalbin-2-like [Glycine max] gi|356535625|ref|XP_003536345.1|
Domains
16
Lj0g3v0288789.1
– PREDICTED: tricalbin-2-like [Glycine max] gi|356535625|ref|XP_003536345.1|
Domains
16
Lj1g3v3342730.1
– PREDICTED: synaptotagmin-2-like isoform X2 [Cicer arietinum] gi|502130682|ref|XP_004500733.1|
Domains
4
Lj3g3v2720280.2
– PREDICTED: extended synaptotagmin-2-like [Glycine max] gi|356505439|ref|XP_003521498.1|
Domains
22
Lj4g3v1893260.1
– PREDICTED: synaptotagmin-5-like isoform X2 [Cicer arietinum] gi|502151448|ref|XP_004508446.1|
Domains
8
Lj5g3v0239180.1
– PREDICTED: extended synaptotagmin-1-like [Glycine max] gi|356553367|ref|XP_003545028.1|
Domains
17
LotjaGi1g1v0381800.1
– Synaptotagmin-5; TAIR: AT5G11100.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|A0JJX5|SYT4_ARATH Synaptotagmin-4; TrEMBL-Plants: tr|A0A0R0JHJ4|A0A0R0JHJ4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0381800
Domains
19
LotjaGi1g1v0381800.2
– Synaptotagmin-5; TAIR: AT5G11100.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|A0JJX5|SYT4_ARATH Synaptotagmin-4; TrEMBL-Plants: tr|I1K8T0|I1K8T0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0381800
Domains
13
LotjaGi1g1v0381800.3
– Synaptotagmin-5; TAIR: AT5G11100.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|A0JJX5|SYT4_ARATH Synaptotagmin-4; TrEMBL-Plants: tr|A0A0R0JHJ4|A0A0R0JHJ4_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0381800
Domains
19
LotjaGi1g1v0465600.1
– Calcium lipid binding protein, putative; TAIR: AT3G61050.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|A0JJX5|SYT4_ARATH Synaptotagmin-4; TrEMBL-Plants: tr|I1L6S3|I1L6S3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0465600
Domains
24
LotjaGi1g1v0465600.2
– Calcium lipid binding protein, putative; TAIR: AT3G61050.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|A0JJX5|SYT4_ARATH Synaptotagmin-4; TrEMBL-Plants: tr|I1L6S3|I1L6S3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0465600
Domains
24
LotjaGi1g1v0465600.3
– Extended synaptotagmin-2; TAIR: AT3G61050.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|Q8L706|SYT5_ARATH Synaptotagmin-5; TrEMBL-Plants: tr|G7L1E7|G7L1E7_MEDTR C2 calcium/lipid-binding and GRAM domain protein; Found in the gene: LotjaGi1g1v0465600
Domains
13
LotjaGi1g1v0465600.4
– Synaptotagmin-5; TAIR: AT3G61050.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|A0JJX5|SYT4_ARATH Synaptotagmin-4; TrEMBL-Plants: tr|A0A0B2P651|A0A0B2P651_GLYSO Extended synaptotagmin-2; Found in the gene: LotjaGi1g1v0465600
Domains
21
LotjaGi1g1v0465600.5
– Calcium lipid binding protein, putative; TAIR: AT3G61050.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|A0JJX5|SYT4_ARATH Synaptotagmin-4; TrEMBL-Plants: tr|I1L6S3|I1L6S3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0465600
Domains
24
LotjaGi1g1v0465600.6
– Calcium lipid binding protein, putative; TAIR: AT3G61050.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|A0JJX5|SYT4_ARATH Synaptotagmin-4; TrEMBL-Plants: tr|I1L6S3|I1L6S3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0465600
Domains
17
LotjaGi1g1v0559400.1
– Synaptotagmin-1; TAIR: AT1G20080.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|B6ETT4|SYT2_ARATH Synaptotagmin-2; TrEMBL-Plants: tr|A0A151TMN0|A0A151TMN0_CAJCA Extended synaptotagmin-2-B; Found in the gene: LotjaGi1g1v0559400
Domains
19
LotjaGi1g1v0559400.2
– Synaptotagmin, putative; TAIR: AT1G20080.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|B6ETT4|SYT2_ARATH Synaptotagmin-2; TrEMBL-Plants: tr|A0A1J7IIF6|A0A1J7IIF6_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0559400
Domains
15
LotjaGi2g1v0169800.1
– Testis-expressed sequence 2 protein; TAIR: AT1G17820.1 testis-expressed sequence 2-like protein (DUF2404); Swiss-Prot: sp|Q6ZPJ0|TEX2_MOUSE Testis-expressed protein 2; TrEMBL-Plants: tr|A0A0B2QWR0|A0A0B2QWR0_GLYSO Testis-expressed sequence 2 protein; Found in the gene: LotjaGi2g1v0169800
Domains
7
LotjaGi2g1v0169800.2
– Testis-expressed sequence 2 protein; TAIR: AT1G17820.1 testis-expressed sequence 2-like protein (DUF2404); Swiss-Prot: sp|Q6ZPJ0|TEX2_MOUSE Testis-expressed protein 2; TrEMBL-Plants: tr|A0A0B2QWR0|A0A0B2QWR0_GLYSO Testis-expressed sequence 2 protein; Found in the gene: LotjaGi2g1v0169800
Domains
14
LotjaGi2g1v0206200.1
– C2 domain-containing family protein; TAIR: AT3G18370.1 C2 domain-containing protein; Swiss-Prot: sp|Q8L706|SYT5_ARATH Synaptotagmin-5; TrEMBL-Plants: tr|G7KN36|G7KN36_MEDTR Plant synaptotagmin; Found in the gene: LotjaGi2g1v0206200
Domains
15
LotjaGi2g1v0206200.2
– C2 domain-containing family protein; TAIR: AT3G18370.1 C2 domain-containing protein; Swiss-Prot: sp|Q8L706|SYT5_ARATH Synaptotagmin-5; TrEMBL-Plants: tr|A0A1J7GSW8|A0A1J7GSW8_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0206200
Domains
14
LotjaGi3g1v0147400.1
– C2 domain-containing protein; TAIR: AT1G53590.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|Q93XX4|C2D61_ARATH C2 domain-containing protein At1g53590; TrEMBL-Plants: tr|A0A072VA30|A0A072VA30_MEDTR Calcium-dependent lipid-binding domain protein; Found in the gene: LotjaGi3g1v0147400
Domains
16
LotjaGi3g1v0147400.2
– C2 domain-containing protein; TAIR: AT1G53590.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|Q93XX4|C2D61_ARATH C2 domain-containing protein At1g53590; TrEMBL-Plants: tr|A0A072VA30|A0A072VA30_MEDTR Calcium-dependent lipid-binding domain protein; Found in the gene: LotjaGi3g1v0147400
Domains
16
LotjaGi3g1v0430200.1
– Calcium lipid binding protein, putative; TAIR: AT3G61050.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|A0JJX5|SYT4_ARATH Synaptotagmin-4; TrEMBL-Plants: tr|K7KCB9|K7KCB9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0430200
Domains
22
LotjaGi3g1v0430200.2
– Synaptotagmin-5; TAIR: AT3G61050.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|A0JJX5|SYT4_ARATH Synaptotagmin-4; TrEMBL-Plants: tr|K7KCB9|K7KCB9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0430200
Domains
19
LotjaGi3g1v0430200.3
– Calcium lipid binding protein, putative; TAIR: AT3G61050.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|A0JJX5|SYT4_ARATH Synaptotagmin-4; TrEMBL-Plants: tr|K7KCB9|K7KCB9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0430200
Domains
22
LotjaGi3g1v0430200.4
– Calcium lipid binding protein, putative; TAIR: AT3G61050.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|A0JJX5|SYT4_ARATH Synaptotagmin-4; TrEMBL-Plants: tr|I1JKI9|I1JKI9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0430200
Domains
20
LotjaGi3g1v0521200.1
– Synaptotagmin-1; TAIR: AT2G20990.1 synaptotagmin A; Swiss-Prot: sp|Q9SKR2|SYT1_ARATH Synaptotagmin-1; TrEMBL-Plants: tr|K7LST9|K7LST9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0521200
Domains
19
LotjaGi3g1v0521200.2
– Calcium lipid binding protein, putative; TAIR: AT2G20990.1 synaptotagmin A; Swiss-Prot: sp|Q9SKR2|SYT1_ARATH Synaptotagmin-1; TrEMBL-Plants: tr|I1LJ17|I1LJ17_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0521200
Domains
19
LotjaGi3g1v0521200.3
– Calcium-dependent lipid-binding (CaLB domain) family protein; TAIR: AT2G20990.1 synaptotagmin A; Swiss-Prot: sp|Q9SKR2|SYT1_ARATH Synaptotagmin-1; TrEMBL-Plants: tr|I1LJ17|I1LJ17_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0521200
Domains
19
LotjaGi3g1v0521200.4
– Synaptotagmin-1; TAIR: AT2G20990.1 synaptotagmin A; Swiss-Prot: sp|Q9SKR2|SYT1_ARATH Synaptotagmin-1; TrEMBL-Plants: tr|K7LST9|K7LST9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0521200
Domains
15
LotjaGi3g1v0521200.5
– Synaptotagmin, putative; TAIR: AT1G20080.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|B6ETT4|SYT2_ARATH Synaptotagmin-2; TrEMBL-Plants: tr|I1LPS0|I1LPS0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0521200
Domains
15
LotjaGi3g1v0526000.1
– Calcium-dependent lipid-binding domain protein; TAIR: AT3G19830.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|Q9BSJ8|ESYT1_HUMAN Extended synaptotagmin-1; TrEMBL-Plants: tr|A0A1J7HYK5|A0A1J7HYK5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0526000
Domains
16
LotjaGi4g1v0277600.1
– Synaptotagmin-5; TAIR: AT1G05500.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|Q8L706|SYT5_ARATH Synaptotagmin-5; TrEMBL-Plants: tr|A0A0B2Q5D1|A0A0B2Q5D1_GLYSO Extended synaptotagmin-3; Found in the gene: LotjaGi4g1v0277600
Domains
19
LotjaGi4g1v0277600.2
– Synaptotagmin-5; TAIR: AT1G05500.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|Q8L706|SYT5_ARATH Synaptotagmin-5; TrEMBL-Plants: tr|A0A1J7GHG0|A0A1J7GHG0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0277600
Domains
8
LotjaGi5g1v0004700.1
– Synaptotagmin-1; TAIR: AT1G20080.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|B6ETT4|SYT2_ARATH Synaptotagmin-2; TrEMBL-Plants: tr|A0A151UDU8|A0A151UDU8_CAJCA Extended synaptotagmin-2; Found in the gene: LotjaGi5g1v0004700
Domains
20
LotjaGi5g1v0004700.2
– Synaptotagmin-1; TAIR: AT1G20080.1 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|B6ETT4|SYT2_ARATH Synaptotagmin-2; TrEMBL-Plants: tr|A0A151UDU8|A0A151UDU8_CAJCA Extended synaptotagmin-2; Found in the gene: LotjaGi5g1v0004700
Domains
20
LotjaGi5g1v0004700.3
– Synaptotagmin-1; TAIR: AT2G20990.1 synaptotagmin A; Swiss-Prot: sp|Q9SKR2|SYT1_ARATH Synaptotagmin-1; TrEMBL-Plants: tr|A0A151UDU8|A0A151UDU8_CAJCA Extended synaptotagmin-2; Found in the gene: LotjaGi5g1v0004700
Domains
16
LotjaGi5g1v0273300.1
– Calcium lipid binding protein, putative; TAIR: AT5G04220.3 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|Q7XA06|SYT3_ARATH Synaptotagmin-3; TrEMBL-Plants: tr|A0A151SED0|A0A151SED0_CAJCA Extended synaptotagmin-2; Found in the gene: LotjaGi5g1v0273300
Domains
15
LotjaGi5g1v0273300.2
– Synaptotagmin-2; TAIR: AT5G04220.2 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|Q7XA06|SYT3_ARATH Synaptotagmin-3; TrEMBL-Plants: tr|I1LD00|I1LD00_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0273300
Domains
19
LotjaGi5g1v0273300.3
– Calcium-dependent lipid-binding (CaLB domain) family protein; TAIR: AT5G04220.2 Calcium-dependent lipid-binding (CaLB domain) family protein; Swiss-Prot: sp|Q7XA06|SYT3_ARATH Synaptotagmin-3; TrEMBL-Plants: tr|I1LD00|I1LD00_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0273300
Domains
19

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd00030 CDD 1 2.22