Overview

Relationships

The relationship of GO:0000159 with other GO terms.

Ancestor tree

A force layout showing the ancestor tree for GO:0000159, and its immediate children. If you wish to explore the tree dynamically, please use the GO Explorer.

• Drag and drop nodes to manually position (i.e. fix) them
• Double click on a node to unfix the node
• Press Alt and double click to visit the page containing further details of a GO term
• Right clicking on a node will reveal a context menu

Additional data

This table contains additional metadata associated with the GO entry's definition field.

Field	Value
GOC	mah
ISBN	Oxford Dictionary of Biochemistry and Molecular Biology Anthony David Smith · ISBN: 0198547684 Oxford University Press, USA, 1997 · 762 pages Arranged in A-to-Z order, the more than 17,000 entries provide basic information about fundamental, physiochemical laws, chemical compounds, constants, and formulae. The Dictionary also describes the essential features of some 2,000 enzymes and proteins, the reactions they catalyze and the functions they perform. These entries also include filenames to facilitate the location of entries in databases of sequences and definitions of 950 abbreviations and symbols. Designed for students, teachers, researchers and other professionals in any area of the biomedical sciences, the Dictionary has been fully updated anf revised to incorporate new information discovered since the original edition was published in 1997.
PMID	A specific PP2A regulatory subunit, B56gamma, mediates DNA damage-induced dephosphorylation of p53 at Thr55.Li HH, Cai X, Shouse GP, Piluso LG, Liu X EMBO J. 2007 Jan 24; 26 (2): 402–11.PMID: 17245430 Protein phosphatase 2A (PP2A) has been implicated to exert its tumor suppressive function via a small subset of regulatory subunits. In this study, we reported that the specific B regulatory subunits of PP2A B56gamma1 and B56gamma3 mediate dephosphorylation of p53 at Thr55. Ablation of the B56gamma protein by RNAi, which abolishes the Thr55 dephosphorylation in response to DNA damage, reduces p53 stabilization, Bax expression and cell apoptosis. To investigate the molecular mechanisms, we have shown that the endogenous B56gamma protein level and association with p53 increase after DNA damage. Finally, we demonstrate that Thr55 dephosphorylation is required for B56gamma3-mediated inhibition of cell proliferation and cell transformation. These results suggest a molecular mechanism for B56gamma-mediated tumor suppression and provide a potential route for regulation of B56gamma-specific PP2A complex function.

Associated Lotus transcripts 63

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Co-occuring GO terms 1

A list of co-occurring GO terms within the L. japonicus gene space: