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IPR004331 is a SPX domain.
<p>The SPX domain is named after SYG1/Pho81/XPR1 proteins. This 180 residue length domain is found at the amino terminus of a variety of proteins. In the yeast protein SYG1, the N terminus directly binds to the G- protein beta subunit and inhibits transduction of the mating pheromone signal [[cite:PUB00007515]] suggesting that all the members of this family are involved in G-protein associated signal transduction. The C-terminal of these proteins often have an EXS domain ([interpro:IPR004342]) [[cite:PUB00007516]].</p> <p>The N-termini of several proteins involved in the regulation of phosphate transport, including the putative phosphate level sensors PHO81 from Saccharomyces cerevisiae and NUC-2 from Neurospora crassa, are also members of this family [[cite:PUB00007517], [cite:PUB00007518]]. NUC-2 contains several ankyrin repeats ([interpro:IPR002110]).</p> <p>Several members of this family are the XPR1 proteins: the xenotropic and polytropic retrovirus receptor confers susceptibility to infection with Murine leukemia virus (MLV) [[cite:PUB00007516]]. The similarity between SYG1, phosphate regulators and XPR1 sequences has been previously noted, as has the additional similarity to several predicted proteins, of unknown function, from Drosophila melanogaster, Arabidopsis thaliana, Caenorhabditis elegans, Schizosaccharomyces pombe, and Saccharomyces cerevisiae [[cite:PUB00007516], [cite:PUB00007519]]. In addition, given the similarities between XPR1 and SYG1 and phosphate regulatory proteins, it has been proposed that XPR1 might be involved in G-protein associated signal transduction [[cite:PUB00043762], [cite:PUB00043763], [cite:PUB00043764]] and may itself function as a phosphate sensor [[cite:PUB00007516]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: SPX domain-containing membrane protein At4g22990-like isoform 1 [Glycine max] gi|356532044|ref|XP_003534584.1| | 17 | ||
| – | PREDICTED: SPX domain-containing membrane protein At4g22990-like [Cicer arietinum] gi|502180691|ref|XP_004516695.1| | 16 | ||
| – | PREDICTED: SPX domain-containing membrane protein At4g22990-like [Cicer arietinum] gi|502180691|ref|XP_004516695.1| | 16 | ||
| – | PREDICTED: SPX domain-containing protein 3-like [Glycine max] gi|356496328|ref|XP_003517020.1| | 7 | ||
| – | Vacuolar transporter chaperone [Medicago truncatula] gi|357436969|ref|XP_003588760.1| | 7 | ||
| – | PREDICTED: SPX domain-containing protein 2-like [Glycine max] gi|356548579|ref|XP_003542678.1| | 8 | ||
| – | PREDICTED: SPX domain-containing membrane protein At4g22990-like isoform 1 [Glycine max] gi|356532044|ref|XP_003534584.1| | 17 | ||
| – | PREDICTED: phosphate transporter PHO1 homolog 9-like [Glycine max] gi|356568688|ref|XP_003552542.1| | 15 | ||
| – | PREDICTED: phosphate transporter PHO1 homolog 9-like [Glycine max] gi|356568688|ref|XP_003552542.1| | 15 | ||
| – | PREDICTED: E3 ubiquitin-protein ligase BAH1-like isoform 1 [Glycine max] gi|356505572|ref|XP_003521564.1| | 16 | ||
| – | SPX-domain protein [Medicago truncatula] gi|357518245|ref|XP_003629411.1| | 7 | ||
| – | PREDICTED: phosphate transporter PHO1 homolog 1-like isoform 1 [Glycine max] gi|356496020|ref|XP_003516868.1| | 13 | ||
| – | PREDICTED: phosphate transporter PHO1 homolog 1-like isoform 1 [Glycine max] gi|356496020|ref|XP_003516868.1| | 14 | ||
| – | PREDICTED: phosphate transporter PHO1 homolog 10-like [Glycine max] gi|356502567|ref|XP_003520090.1| | 13 | ||
| – | PREDICTED: SPX domain-containing protein 3-like [Glycine max] gi|356496328|ref|XP_003517020.1| | 6 | ||
| – | PREDICTED: SPX domain-containing protein 2-like [Glycine max] gi|356548579|ref|XP_003542678.1| | 8 | ||
| – | PREDICTED: phosphate transporter PHO1 homolog 1-like isoform 1 [Glycine max] gi|356500006|ref|XP_003518826.1| | 12 | ||
| – | PREDICTED: phosphate transporter PHO1 homolog 1-like isoform 1 [Glycine max] gi|356500006|ref|XP_003518826.1| | 12 | ||
| – | Vacuolar transporter chaperone [Medicago truncatula] gi|357436969|ref|XP_003588760.1| | 7 | ||
| – | PREDICTED: SPX domain-containing protein 2-like [Glycine max] gi|356548579|ref|XP_003542678.1| | 8 | ||
| – | PREDICTED: phosphate transporter PHO1-like [Glycine max] gi|356535386|ref|XP_003536227.1| | 13 | ||
| – | PREDICTED: phosphate transporter PHO1-like [Glycine max] gi|356535386|ref|XP_003536227.1| | 14 | ||
| – | PREDICTED: E3 ubiquitin-protein ligase BAH1-like isoform X1 [Cicer arietinum] gi|502117818|ref|XP_004495961.1| | 16 | ||
| – | Vacuolar transporter chaperone [Medicago truncatula] gi|357436969|ref|XP_003588760.1| | 7 | ||
| – | Pho1-like protein [Medicago truncatula] gi|357452341|ref|XP_003596447.1| | 14 | ||
| – | SPX domain-containing family protein; TAIR: AT5G20150.1 SPX domain-containing protein 1; Swiss-Prot: sp|Q8LBH4|SPX1_ARATH SPX domain-containing protein 1; TrEMBL-Plants: tr|A0A0U1SH93|A0A0U1SH93_SOYBN SPX domain-containing protein 3; Found in the gene: LotjaGi1g1v0199500 | 8 | ||
| – | SPX domain-containing family protein; TAIR: AT4G22990.2 Major Facilitator Superfamily with SPX (SYG1/Pho81/XPR1) domain-containing protein; Swiss-Prot: sp|Q93ZQ5|SPXM3_ARATH SPX domain-containing membrane protein At4g22990; TrEMBL-Plants: tr|A0A151TBH1|A0A151TBH1_CAJCA Putative membrane protein family; Found in the gene: LotjaGi1g1v0471200 | 16 | ||
| – | SPX domain-containing family protein; TAIR: AT4G22990.1 Major Facilitator Superfamily with SPX (SYG1/Pho81/XPR1) domain-containing protein; Swiss-Prot: sp|Q93ZQ5|SPXM3_ARATH SPX domain-containing membrane protein At4g22990; TrEMBL-Plants: tr|A0A151TBH1|A0A151TBH1_CAJCA Putative membrane protein family; Found in the gene: LotjaGi1g1v0471200 | 16 | ||
| – | SPX domain-containing family protein; TAIR: AT4G22990.1 Major Facilitator Superfamily with SPX (SYG1/Pho81/XPR1) domain-containing protein; Swiss-Prot: sp|Q93ZQ5|SPXM3_ARATH SPX domain-containing membrane protein At4g22990; TrEMBL-Plants: tr|A0A151TBH1|A0A151TBH1_CAJCA Putative membrane protein family; Found in the gene: LotjaGi1g1v0471200 | 16 | ||
| – | SPX domain-containing family protein; TAIR: AT4G22990.1 Major Facilitator Superfamily with SPX (SYG1/Pho81/XPR1) domain-containing protein; Swiss-Prot: sp|Q93ZQ5|SPXM3_ARATH SPX domain-containing membrane protein At4g22990; TrEMBL-Plants: tr|A0A151TBH1|A0A151TBH1_CAJCA Putative membrane protein family; Found in the gene: LotjaGi1g1v0471200 | 16 | ||
| – | SPX domain-containing membrane protein; TAIR: AT4G22990.1 Major Facilitator Superfamily with SPX (SYG1/Pho81/XPR1) domain-containing protein; Swiss-Prot: sp|Q93ZQ5|SPXM3_ARATH SPX domain-containing membrane protein At4g22990; TrEMBL-Plants: tr|A0A151TBH1|A0A151TBH1_CAJCA Putative membrane protein family; Found in the gene: LotjaGi1g1v0471200 | 14 | ||
| – | Phosphate transporter PHO1-like protein; TAIR: AT3G29060.1 EXS (ERD1/XPR1/SYG1) family protein; Swiss-Prot: sp|Q9LJW0|PHO19_ARATH Phosphate transporter PHO1 homolog 9; TrEMBL-Plants: tr|A0A151TCA7|A0A151TCA7_CAJCA Putative phosphate transporter 1; Found in the gene: LotjaGi1g1v0505800 | 16 | ||
| – | SPX domain protein; TAIR: AT2G45130.1 SPX domain protein 3; Swiss-Prot: sp|Q5PP62|SPX3_ARATH SPX domain-containing protein 3; TrEMBL-Plants: tr|K7K3P1|K7K3P1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0601400 | 6 | ||
| – | E3 ubiquitin-protein ligase; TAIR: AT2G38920.1 SPX (SYG1/Pho81/XPR1) domain-containing protein / zinc finger (C3HC4-type RING finger) protein-like protein; Swiss-Prot: sp|Q8GW10|BAH1L_ARATH Probable E3 ubiquitin-protein ligase BAH1-like; TrEMBL-Plants: tr|A0A151TVX6|A0A151TVX6_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0741800 | 16 | ||
| – | E3 ubiquitin-protein ligase; TAIR: AT1G02860.1 SPX (SYG1/Pho81/XPR1) domain-containing protein; Swiss-Prot: sp|Q9SRX9|BAH1_ARATH E3 ubiquitin-protein ligase BAH1; TrEMBL-Plants: tr|A0A0L9UA81|A0A0L9UA81_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0765300 | 15 | ||
| – | E3 ubiquitin-protein ligase; TAIR: AT1G02860.1 SPX (SYG1/Pho81/XPR1) domain-containing protein; Swiss-Prot: sp|Q9SRX9|BAH1_ARATH E3 ubiquitin-protein ligase BAH1; TrEMBL-Plants: tr|A0A0L9UA81|A0A0L9UA81_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0765300 | 15 | ||
| – | SPX domain-containing family protein; TAIR: AT4G22990.1 Major Facilitator Superfamily with SPX (SYG1/Pho81/XPR1) domain-containing protein; Swiss-Prot: sp|Q93ZQ5|SPXM3_ARATH SPX domain-containing membrane protein At4g22990; TrEMBL-Plants: tr|A0A1J7GX73|A0A1J7GX73_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0138800 | 14 | ||
| – | SPX domain-containing family protein; TAIR: AT4G22990.2 Major Facilitator Superfamily with SPX (SYG1/Pho81/XPR1) domain-containing protein; Swiss-Prot: sp|Q93ZQ5|SPXM3_ARATH SPX domain-containing membrane protein At4g22990; TrEMBL-Plants: tr|A0A1J7GX73|A0A1J7GX73_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0138800 | 14 | ||
| – | SPX domain-containing family protein; TAIR: AT4G22990.2 Major Facilitator Superfamily with SPX (SYG1/Pho81/XPR1) domain-containing protein; Swiss-Prot: sp|Q93ZQ5|SPXM3_ARATH SPX domain-containing membrane protein At4g22990; TrEMBL-Plants: tr|A0A1J7GX73|A0A1J7GX73_LUPAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0138800 | 14 | ||
| – | SPX domain protein; TAIR: AT5G15330.1 SPX domain-containing protein 4; Swiss-Prot: sp|Q94A21|SPX4_ARATH SPX domain-containing protein 4; TrEMBL-Plants: tr|I3S328|I3S328_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0261200 | 9 | ||
| – | Phosphate transporter PHO1-like protein; TAIR: AT1G68740.1 EXS (ERD1/XPR1/SYG1) family protein; Swiss-Prot: sp|Q93ZF5|PHO11_ARATH Phosphate transporter PHO1 homolog 1; TrEMBL-Plants: tr|I1J6T3|I1J6T3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0284100 | 15 | ||
| – | Phosphate transporter PHO1-like protein; TAIR: AT1G68740.1 EXS (ERD1/XPR1/SYG1) family protein; Swiss-Prot: sp|Q93ZF5|PHO11_ARATH Phosphate transporter PHO1 homolog 1; TrEMBL-Plants: tr|I1J6T3|I1J6T3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0284100 | 15 | ||
| – | Phosphate transporter PHO1-like protein; TAIR: AT1G69480.1 EXS (ERD1/XPR1/SYG1) family protein; Swiss-Prot: sp|Q6R8G0|PHO1A_ARATH Phosphate transporter PHO1 homolog 10; TrEMBL-Plants: tr|G7JWG7|G7JWG7_MEDTR Phosphate transporter PHO1-like protein; Found in the gene: LotjaGi2g1v0300900 | 15 | ||
| – | Phosphate transporter PHO1-like protein; TAIR: AT1G69480.1 EXS (ERD1/XPR1/SYG1) family protein; Swiss-Prot: sp|Q6R8G0|PHO1A_ARATH Phosphate transporter PHO1 homolog 10; TrEMBL-Plants: tr|G7JWG7|G7JWG7_MEDTR Phosphate transporter PHO1-like protein; Found in the gene: LotjaGi2g1v0300900 | 15 | ||
| – | SPX domain-containing protein; TAIR: AT2G45130.1 SPX domain protein 3; Swiss-Prot: sp|Q5PP62|SPX3_ARATH SPX domain-containing protein 3; TrEMBL-Plants: tr|K7K3P1|K7K3P1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0206000 | 7 | ||
| – | Phosphate transporter PHO1-like protein; TAIR: AT1G68740.1 EXS (ERD1/XPR1/SYG1) family protein; Swiss-Prot: sp|Q93ZF5|PHO11_ARATH Phosphate transporter PHO1 homolog 1; TrEMBL-Plants: tr|A0A1J7HP60|A0A1J7HP60_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0152100 | 16 | ||
| – | Phosphate transporter PHO1 like 1; TAIR: AT1G68740.1 EXS (ERD1/XPR1/SYG1) family protein; Swiss-Prot: sp|Q93ZF5|PHO11_ARATH Phosphate transporter PHO1 homolog 1; TrEMBL-Plants: tr|A0A1J7HP60|A0A1J7HP60_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0152100 | 16 | ||
| – | Phosphate transporter PHO1-like protein; TAIR: AT1G68740.1 EXS (ERD1/XPR1/SYG1) family protein; Swiss-Prot: sp|Q93ZF5|PHO11_ARATH Phosphate transporter PHO1 homolog 1; TrEMBL-Plants: tr|A0A1J7HP60|A0A1J7HP60_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0152100 | 16 | ||
| – | SPX domain-containing family protein; TAIR: AT5G20150.1 SPX domain-containing protein 1; Swiss-Prot: sp|Q8LBH4|SPX1_ARATH SPX domain-containing protein 1; TrEMBL-Plants: tr|I3S3A7|I3S3A7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0270900 | 8 | ||
| – | SPX domain-containing family protein; TAIR: AT2G26660.1 SPX domain-containing protein 2 (SPX2); Swiss-Prot: sp|O48781|SPX2_ARATH SPX domain-containing protein 2; TrEMBL-Plants: tr|I3SQV7|I3SQV7_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0060400 | 8 | ||
| – | Phosphate transporter PHO1; TAIR: AT3G23430.1 phosphate 1; Swiss-Prot: sp|Q8S403|PHO1_ARATH Phosphate transporter PHO1; TrEMBL-Plants: tr|A0A151U5X3|A0A151U5X3_CAJCA Putative phosphate transporter 1; Found in the gene: LotjaGi5g1v0188800 | 15 | ||
| – | Phosphate transporter PHO1; TAIR: AT3G23430.1 phosphate 1; Swiss-Prot: sp|Q8S403|PHO1_ARATH Phosphate transporter PHO1; TrEMBL-Plants: tr|A0A151U5X3|A0A151U5X3_CAJCA Putative phosphate transporter 1; Found in the gene: LotjaGi5g1v0188800 | 15 | ||
| – | E3 ubiquitin-protein ligase; TAIR: AT1G02860.1 SPX (SYG1/Pho81/XPR1) domain-containing protein; Swiss-Prot: sp|Q9SRX9|BAH1_ARATH E3 ubiquitin-protein ligase BAH1; TrEMBL-Plants: tr|I1JQL7|I1JQL7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0251200 | 16 | ||
| – | E3 ubiquitin-protein ligase; TAIR: AT1G02860.1 SPX (SYG1/Pho81/XPR1) domain-containing protein; Swiss-Prot: sp|Q9SRX9|BAH1_ARATH E3 ubiquitin-protein ligase BAH1; TrEMBL-Plants: tr|A0A0L9UA81|A0A0L9UA81_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0251200 | 15 | ||
| – | Phosphate transporter PHO1-like protein; TAIR: AT3G23430.1 phosphate 1; Swiss-Prot: sp|Q8S403|PHO1_ARATH Phosphate transporter PHO1; TrEMBL-Plants: tr|A0A072VHJ2|A0A072VHJ2_MEDTR Phosphate transporter PHO1-like protein; Found in the gene: LotjaGi6g1v0003600 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| mobidb-lite | MobiDBLite | 1 | 1.82 |