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IPR020084

Source: InterPro

Description

IPR020084 is a NUDIX hydrolase, conserved site.

<p>MutT is a small bacterial protein (~12-15Kd) involved in the GO system [[cite:PUB00002202]] responsible for removing an oxidatively damaged form of guanine (8-hydroxy- guanine or 7,8-dihydro-8-oxoguanine) from DNA and the nucleotide pool. 8-oxo-dGTP is inserted opposite dA and dC residues of template DNA with near equal efficiency, leading to A.T to G.C transversions. MutT specifically degrades 8-oxo-dGTP to the monophosphate, with the concomitant release of pyrophosphate. A short conserved N-terminal region of mutT (designated the MutT domain) is also found in a variety of other prokaryotic, viral and eukaryotic proteins [[cite:PUB00004433], [cite:PUB00003856], [cite:PUB00002808], [cite:PUB00006677]].<p>The generic name `NUDIX hydrolases' (NUcleoside DIphosphate linked to some other moiety X) has been coined for this domain family [[cite:PUB00006662]]. The family can be divided into a number of subgroups, of which MutT anti- mutagenic activity represents only one type; most of the rest hydrolyse diverse nucleoside diphosphate derivatives (including ADP-ribose, GDP- mannose, TDP-glucose, NADH, UDP-sugars, dNTP and NTP).</p> <p>This signature covers the core region of the NUDIX domain and contains four conserved glutamate residues [[cite:PUB00004433]]. The region spanned by this signature could be part of the active centre of a family of pyrophosphate-releasing NTPases.</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0016787
Molecular function Hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. Hydrolase is the systematic name for any enzyme of EC class 3.
Subterm of

Associated Lotus transcripts 52

Transcript Name Description Predicted domains Domain count
Lj0g3v0079109.1
– PREDICTED: nudix hydrolase 17, mitochondrial-like [Glycine max] gi|356553271|ref|XP_003544981.1|
Domains
11
Lj0g3v0105609.1
– Nudix hydrolase [Medicago truncatula] gi|357476761|ref|XP_003608666.1|
Domains
12
Lj0g3v0105609.2
– Nudix hydrolase [Medicago truncatula] gi|357476761|ref|XP_003608666.1|
Domains
13
Lj0g3v0201549.1
– PREDICTED: nudix hydrolase 16, mitochondrial-like [Glycine max] gi|356556803|ref|XP_003546710.1|
Domains
11
Lj0g3v0296919.1
– PREDICTED: nudix hydrolase 17, mitochondrial-like [Glycine max] gi|356502376|ref|XP_003519995.1|
Domains
11
Lj0g3v0300239.1
– PREDICTED: mRNA-decapping enzyme subunit 2-like isoform X1 [Cicer arietinum] gi|502169822|ref|XP_004514693.1|
Domains
14
Lj0g3v0334059.1
– PREDICTED: nudix hydrolase 19, chloroplastic-like [Glycine max] gi|356514398|ref|XP_003525893.1|
Domains
13
Lj0g3v0334059.2
– PREDICTED: nudix hydrolase 19, chloroplastic-like [Glycine max] gi|356514398|ref|XP_003525893.1|
Domains
13
Lj1g3v3930310.1
– PREDICTED: nudix hydrolase 12, mitochondrial-like isoform X2 [Cicer arietinum] gi|502106928|ref|XP_004493101.1|
Domains
12
Lj1g3v3930310.2
– PREDICTED: nudix hydrolase 12, mitochondrial-like isoform X2 [Cicer arietinum] gi|502106928|ref|XP_004493101.1|
Domains
11
Lj1g3v4327730.1
– PREDICTED: nudix hydrolase 23, chloroplastic-like [Cicer arietinum] gi|502109215|ref|XP_004493593.1|
Domains
13
Lj2g3v0125090.1
– PREDICTED: nudix hydrolase 25-like [Glycine max] gi|356530740|ref|XP_003533938.1|
Domains
15
Lj2g3v0658260.1
– PREDICTED: nudix hydrolase 4 [Glycine max] gi|356531134|ref|XP_003534133.1|
Domains
11
Lj2g3v1989220.1
– PREDICTED: nudix hydrolase 8-like [Glycine max] gi|356540550|ref|XP_003538751.1|
Domains
13
Lj2g3v1989220.2
– PREDICTED: nudix hydrolase 8-like [Glycine max] gi|356540550|ref|XP_003538751.1|
Domains
17
Lj2g3v1989220.3
– PREDICTED: deSI-like protein At4g17486-like isoform X1 [Cicer arietinum] gi|502160360|ref|XP_004511719.1|
Domains
17
Lj3g3v1907670.1
– PREDICTED: nudix hydrolase 16, mitochondrial-like [Glycine max] gi|356548857|ref|XP_003542815.1|
Domains
11
Lj4g3v0109380.1
– PREDICTED: nudix hydrolase 2-like [Glycine max] gi|356532784|ref|XP_003534950.1|
Domains
12
Lj4g3v1865760.1
– Nudix hydrolase [Medicago truncatula] gi|357477993|ref|XP_003609282.1|
Domains
17
Lj4g3v1865760.3
– Nudix hydrolase [Medicago truncatula] gi|357477993|ref|XP_003609282.1|
Domains
17
Lj4g3v3113010.1
– PREDICTED: nudix hydrolase 17, mitochondrial-like [Glycine max] gi|356513062|ref|XP_003525233.1|
Domains
11
Lj5g3v1697790.1
– PREDICTED: nudix hydrolase 26, chloroplastic-like isoform X2 [Cicer arietinum] gi|502118121|ref|XP_004496111.1|
Domains
15
Lj6g3v0214770.1
– PREDICTED: nudix hydrolase 2-like [Cicer arietinum] gi|502134634|ref|XP_004502189.1|
Domains
19
Lj6g3v0340630.1
– PREDICTED: nudix hydrolase 4 [Glycine max] gi|356531134|ref|XP_003534133.1|
Domains
11
Lj6g3v0410600.1
– Nudix hydrolase [Medicago truncatula] gi|357460851|ref|XP_003600707.1|
Domains
17
Lj6g3v0739980.1
– PREDICTED: nudix hydrolase 2-like [Glycine max] gi|356524366|ref|XP_003530800.1|
Domains
19
LotjaGi1g1v0005100.1
– Nudix family hydrolase; TAIR: AT5G47650.1 nudix hydrolase homolog 2; Swiss-Prot: sp|Q94B74|NUDT2_ARATH Nudix hydrolase 2; TrEMBL-Plants: tr|I1M666|I1M666_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0005100
Domains
16
LotjaGi1g1v0095300.1
– Nudix hydrolase-like protein; TAIR: AT2G01670.1 nudix hydrolase homolog 17; Swiss-Prot: sp|Q9ZU95|NUD17_ARATH Nudix hydrolase 17, mitochondrial; TrEMBL-Plants: tr|A0A151RI97|A0A151RI97_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0095300
Domains
11
LotjaGi1g1v0200500.1
– Nudix family hydrolase; TAIR: AT5G20070.1 nudix hydrolase homolog 19; Swiss-Prot: sp|Q94A82|NUD19_ARATH Nudix hydrolase 19, chloroplastic; TrEMBL-Plants: tr|A0A151UGE9|A0A151UGE9_CAJCA Uncharacterized protein; Found in the gene: LotjaGi1g1v0200500
Domains
18
LotjaGi1g1v0636000.1
– Nudix hydrolase-like protein; TAIR: AT1G12880.1 nudix hydrolase homolog 12; Swiss-Prot: sp|Q93ZY7|NUD12_ARATH Nudix hydrolase 12, mitochondrial; TrEMBL-Plants: tr|I3T351|I3T351_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0636000
Domains
12
LotjaGi1g1v0726600.1
– Nudix hydrolase-like protein; TAIR: AT2G42070.1 nudix hydrolase homolog 23; Swiss-Prot: sp|P93740|NUD23_ARATH Nudix hydrolase 23, chloroplastic; TrEMBL-Plants: tr|I3SGQ4|I3SGQ4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0726600
Domains
13
LotjaGi1g1v0726600.2
– Nudix hydrolase-like protein; TAIR: AT2G42070.1 nudix hydrolase homolog 23; Swiss-Prot: sp|P93740|NUD23_ARATH Nudix hydrolase 23, chloroplastic; TrEMBL-Plants: tr|I3SGQ4|I3SGQ4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0726600
Domains
13
LotjaGi2g1v0063200.1
– RNA pyrophosphohydrolase; TAIR: AT1G30110.1 nudix hydrolase homolog 25; Swiss-Prot: sp|Q9C6Z2|NUD25_ARATH Nudix hydrolase 25; TrEMBL-Plants: tr|I3T716|I3T716_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0063200
Domains
15
LotjaGi2g1v0070200.1
– Nudix hydrolase-like protein; TAIR: AT2G01670.1 nudix hydrolase homolog 17; Swiss-Prot: sp|Q9ZU95|NUD17_ARATH Nudix hydrolase 17, mitochondrial; TrEMBL-Plants: tr|A0A151QZU3|A0A151QZU3_CAJCA Uncharacterized protein; Found in the gene: LotjaGi2g1v0070200
Domains
11
LotjaGi2g1v0119900.1
– MRNA decapping protein 2; TAIR: AT5G13570.1 decapping 2; Swiss-Prot: sp|Q8GW31|DCP2_ARATH mRNA-decapping enzyme subunit 2; TrEMBL-Plants: tr|A0A0L9TCG1|A0A0L9TCG1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0119900
Domains
17
LotjaGi2g1v0119900.3
– MRNA decapping protein 2; TAIR: AT5G13570.1 decapping 2; Swiss-Prot: sp|Q8GW31|DCP2_ARATH mRNA-decapping enzyme subunit 2; TrEMBL-Plants: tr|A0A0L9TCG1|A0A0L9TCG1_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0119900
Domains
17
LotjaGi2g1v0119900.5
– MRNA decapping protein 2; TAIR: AT5G13570.1 decapping 2; Swiss-Prot: sp|Q8GW31|DCP2_ARATH mRNA-decapping enzyme subunit 2; TrEMBL-Plants: tr|C6TF29|C6TF29_SOYBN Putative uncharacterized protein; Found in the gene: LotjaGi2g1v0119900
Domains
17
LotjaGi2g1v0193100.1
– Nudix hydrolase-like protein; TAIR: AT1G18300.1 nudix hydrolase homolog 4; Swiss-Prot: sp|Q9LE73|NUDT4_ARATH Nudix hydrolase 4; TrEMBL-Plants: tr|I3SE70|I3SE70_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0193100
Domains
11
LotjaGi2g1v0193100.2
– Nudix hydrolase-like protein; TAIR: AT1G18300.1 nudix hydrolase homolog 4; Swiss-Prot: sp|Q9LE73|NUDT4_ARATH Nudix hydrolase 4; TrEMBL-Plants: tr|I3SE70|I3SE70_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0193100
Domains
11
LotjaGi2g1v0283400.1
– RNA pyrophosphohydrolase; TAIR: AT1G68760.1 nudix hydrolase 1; Swiss-Prot: sp|Q9CA40|NUDT1_ARATH Nudix hydrolase 1; TrEMBL-Plants: tr|A0A0L9UU59|A0A0L9UU59_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0283400
Domains
12
LotjaGi3g1v0108700.1
– Nudix hydrolase-like protein; TAIR: AT3G12600.1 nudix hydrolase homolog 16; Swiss-Prot: sp|Q9LHK1|NUD16_ARATH Nudix hydrolase 16, mitochondrial; TrEMBL-Plants: tr|A0A151T1U1|A0A151T1U1_CAJCA Uncharacterized protein; Found in the gene: LotjaGi3g1v0108700
Domains
11
LotjaGi3g1v0317100.1
– Nudix hydrolase-like protein; TAIR: AT3G12600.1 nudix hydrolase homolog 16; Swiss-Prot: sp|Q9LHK1|NUD16_ARATH Nudix hydrolase 16, mitochondrial; TrEMBL-Plants: tr|I3T356|I3T356_LOTJA Uncharacterized protein; Found in the gene: LotjaGi3g1v0317100
Domains
11
LotjaGi4g1v0006000.1
– Nudix hydrolase; TAIR: AT5G47650.1 nudix hydrolase homolog 2; Swiss-Prot: sp|Q94B74|NUDT2_ARATH Nudix hydrolase 2; TrEMBL-Plants: tr|I3SKF0|I3SKF0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0006000
Domains
16
LotjaGi4g1v0199700.1
– Nudix family hydrolase; TAIR: AT5G47240.1 nudix hydrolase homolog 8; Swiss-Prot: sp|Q8L7W2|NUDT8_ARATH Nudix hydrolase 8; TrEMBL-Plants: tr|G7JHP2|G7JHP2_MEDTR Nudix family hydrolase; Found in the gene: LotjaGi4g1v0199700
Domains
16
LotjaGi4g1v0268700.1
– Nudix family hydrolase; TAIR: AT5G20070.1 nudix hydrolase homolog 19; Swiss-Prot: sp|Q94A82|NUD19_ARATH Nudix hydrolase 19, chloroplastic; TrEMBL-Plants: tr|G7JVC3|G7JVC3_MEDTR Nudix family hydrolase; Found in the gene: LotjaGi4g1v0268700
Domains
18
LotjaGi4g1v0268700.2
– Nudix family hydrolase; TAIR: AT5G20070.1 nudix hydrolase homolog 19; Swiss-Prot: sp|Q94A82|NUD19_ARATH Nudix hydrolase 19, chloroplastic; TrEMBL-Plants: tr|G7JVC3|G7JVC3_MEDTR Nudix family hydrolase; Found in the gene: LotjaGi4g1v0268700
Domains
18
LotjaGi4g1v0456400.1
– Nudix hydrolase-like protein; TAIR: AT2G01670.1 nudix hydrolase homolog 17; Swiss-Prot: sp|Q9ZU95|NUD17_ARATH Nudix hydrolase 17, mitochondrial; TrEMBL-Plants: tr|I3S2L4|I3S2L4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi4g1v0456400
Domains
11
LotjaGi5g1v0255500.1
– RNA pyrophosphohydrolase; TAIR: AT3G10620.1 nudix hydrolase homolog 26; Swiss-Prot: sp|Q9CAF2|NUD26_ARATH Nudix hydrolase 26, chloroplastic; TrEMBL-Plants: tr|I3T6R0|I3T6R0_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0255500
Domains
15
LotjaGi6g1v0024100.1
– Nudix family hydrolase; TAIR: AT5G47650.1 nudix hydrolase homolog 2; Swiss-Prot: sp|Q94B74|NUDT2_ARATH Nudix hydrolase 2; TrEMBL-Plants: tr|I1NDT8|I1NDT8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0024100
Domains
16
LotjaGi6g1v0024100.2
– Nudix family hydrolase; TAIR: AT5G47650.1 nudix hydrolase homolog 2; Swiss-Prot: sp|Q94B74|NUDT2_ARATH Nudix hydrolase 2; TrEMBL-Plants: tr|G7J8V6|G7J8V6_MEDTR Nudix family hydrolase; Found in the gene: LotjaGi6g1v0024100
Domains
23
LotjaGi6g1v0055500.1
– Nudix hydrolase-like protein; TAIR: AT2G01670.1 nudix hydrolase homolog 17; Swiss-Prot: sp|Q9ZU95|NUD17_ARATH Nudix hydrolase 17, mitochondrial; TrEMBL-Plants: tr|I3SJG4|I3SJG4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0055500
Domains
17
LotjaGi6g1v0142600.1
– Nudix family hydrolase; TAIR: AT4G25434.10 nudix hydrolase homolog 10; Swiss-Prot: sp|Q6NPD7|NUD10_ARATH Nudix hydrolase 10; TrEMBL-Plants: tr|A0A0L9VBB2|A0A0L9VBB2_PHAAN Uncharacterized protein; Found in the gene: LotjaGi6g1v0142600
Domains
22

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
cd04670 CDD 1 1.92