Description

IPR000164 is a Histone H3/CENP-A.

<p>This entry includes histone H3 and its variant, CENP-A (Cse4 in budding yeast, Cnp1 in fission yeast, and CID/CenH3 in fruit flies). Two primate-specific forms of H3, known as H3.X and H3.Y, are found in the brain [[cite:PUB00090177]].</p> <p>Histone H3 is one of the five histones, along with H1/H5, H2A, H2B and H4. Two copies of each of the H2A, H2B, H3, and H4 histones ensemble to form the core of the nucleosome [[cite:PUB00066796]]. The nucleosome forms octameric structure that wraps DNA in a left-handed manner. H3 is a highly conserved protein of 135 amino acid residues [[cite:PUB00004448], [cite:PUB00004388]]. Histones can undergo several different types of post-translational modifications that affect transcription, DNA repair, DNA replication and chromosomal stability.</p> <p>Eukaryotic centromeres consists of an unique nucleosome in which CENP-A can be found [[cite:PUB00070934]]. Human CENP-A nucleosome forms a histone octamer containing two each of histones H2A, H2B, H4 and CENP-A. Similar to the H3-containing nucleosome, the CENP-A nucleosome wraps DNA in a left-handed orientation [[cite:PUB00070935], [cite:PUB00070936]]. CENP-A nucleosomes function as a scaffold on which other kinetochore proteins assemble. CENP-A may serves as an epigenetic marker for kinetochore assembly [[cite:PUB00070937]]. Deposition of CENP-A to the centromere requires histone chaperone HJURP (Holliday junction recognition protein) [[cite:PUB00070938]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 108

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: