Description

IPR003347 is a JmjC domain.

<p>The JmjN and JmjC domains are two non-adjacent domains which have been identified in the jumonji family of transcription factors. Although it was originally suggested that the JmjN and JmjC domains always co-occur and might form a single functional unit within the folded protein, the JmjC domain was later found without the JmjN domain in organisms from bacteria to human [[cite:PUB00008126], [cite:PUB00007419], [cite:PUB00099121]].</p> <p>Proteins containing JmjC domain are predicted to be metalloenzymes that adopt the cupin fold and are candidates for enzymes that regulate chromatin remodelling [[cite:PUB00007419]]. The cupin fold is a flattened β-barrel structure containing two sheets of five antiparallel β-strands that form the walls of a zinc-binding cleft. Based on the crystal structure of JmjC domain containing protein FIH and JHDM3A/JMJD2A, the JmjC domain forms an enzymatically active pocket that coordinates Fe(III) and alphaKG. Three amino-acid residues within the JmjC domain bind to the Fe(II) cofactor and two additional residues bind to alphaKG [[cite:PUB00070012]].</p> <p>JmjC domains were identified in numerous eukaryotic proteins containing domains typical of transcription factors, such as PHD, C2H2, ARID/BRIGHT and zinc fingers [[cite:PUB00007419], [cite:PUB00021723]]. The JmjC has been shown to function in a histone demethylation mechanism that is conserved from yeast to human [[cite:PUB00033727]]. JmjC domain proteins may be protein hydroxylases that catalyse a novel histone modification [[cite:PUB00021054]]. The human JmjC protein named Tyw5p unexpectedly acts in the biosynthesis of a hypermodified nucleoside, hydroxy-wybutosine, in tRNA-Phe by catalysing hydroxylation [[cite:PUB00057442]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

Unable to find any GO terms for the transcript with the identifier.

Associated Lotus transcripts 78

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: