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IPR004176 is a Clp, repeat (R) domain.
<p>Molecular chaperones recognize unfolded or misfolded proteins by binding to hydrophobic surface patches not normally exposed in the native proteins. Members of the Clp/Hsp100 family of chaperones are present in eubacteria and within organelles of all eukaryotes, promoting disaggregation and disassembly of protein complexes and participating in energy-dependent protein degradation. The ClpA, ClpB, and ClpC subfamilies of the Clp/Hsp100 ATPases contain a conserved N-terminal domain of ~150 amino acids, which in turn consists of two repeats of ~75 residues. Although the Clp repeat (R) domain contains two approximate sequence repeats, it behaves as a single cooperatively folded unit. The Clp R domain is thought to provide a means for regulating the specificity of and to enlarge the substrate pool available to Clp/Hsp100 chaperone or protease complexes. These roles can be assisted through the binding of an adaptor protein. Adaptor proteins bind to the Clp R domain, modulate the target specificity of the Clp/Hsp100 complex to a particular substrate of interest, and may also regulate the activity of the complex [[cite:PUB00094776], [cite:PUB00030547], [cite:PUB00094777], [cite:PUB00048252], [cite:PUB00094775], [cite:PUB00094778]].</p> <p>The Clp R domain is monomeric and partially α helical. It is a single folding unit with pseudo 2-fold symmetry. The Clp R domain structure consists of two four-helix bundles connected by a flexible loop [[cite:PUB00030547], [cite:PUB00094777], [cite:PUB00048252]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: chaperone protein ClpB4, mitochondrial-like [Glycine max] gi|356507345|ref|XP_003522428.1| | 10 | ||
| – | PREDICTED: chaperone protein ClpB-like [Glycine max] gi|356551867|ref|XP_003544294.1| | 6 | ||
| – | PREDICTED: chaperone protein ClpD, chloroplastic-like [Glycine max] gi|356507402|ref|XP_003522456.1| | 26 | ||
| – | PREDICTED: chaperone protein ClpC, chloroplastic-like [Glycine max] gi|356516495|ref|XP_003526929.1| | 21 | ||
| – | PREDICTED: chaperone protein ClpB4, mitochondrial-like [Cicer arietinum] gi|502132470|ref|XP_004501376.1| | 30 | ||
| – | PREDICTED: chaperone protein ClpB3, chloroplastic-like isoform X1 [Cicer arietinum] gi|502101806|ref|XP_004491878.1| | 28 | ||
| – | PREDICTED: chaperone protein ClpB3, chloroplastic-like isoform X2 [Cicer arietinum] gi|502101810|ref|XP_004491879.1| | 28 | ||
| – | PREDICTED: chaperone protein ClpC, chloroplastic-like isoform 1 [Glycine max] gi|356508861|ref|XP_003523172.1| | 11 | ||
| – | PREDICTED: clp protease-related protein At4g12060, chloroplastic-like [Glycine max] gi|356530947|ref|XP_003534040.1| | 6 | ||
| – | Chaperone protein clpB [Medicago truncatula] gi|357496641|ref|XP_003618609.1| | 28 | ||
| – | Chaperone protein clpB [Medicago truncatula] gi|357496641|ref|XP_003618609.1| | 28 | ||
| – | PREDICTED: chaperone protein ClpB-like [Cicer arietinum] gi|502096027|ref|XP_004490602.1| | 5 | ||
| – | PREDICTED: chaperone protein ClpB-like [Cicer arietinum] gi|502096027|ref|XP_004490602.1| | 5 | ||
| – | Heat shock protein [Glycine max] gi|351725607|ref|NP_001238122.1| | 26 | ||
| – | PREDICTED: chaperone protein ClpC, chloroplastic-like isoform 1 [Glycine max] gi|356508861|ref|XP_003523172.1| | 24 | ||
| – | PREDICTED: chaperone protein ClpC, chloroplastic-like isoform 1 [Glycine max] gi|356508861|ref|XP_003523172.1| | 33 | ||
| – | PREDICTED: chaperone protein ClpB1-like [Vitis vinifera] gi|225440714|ref|XP_002275038.1| | 10 | ||
| – | PREDICTED: chaperone protein ClpB1-like [Glycine max] gi|356533866|ref|XP_003535479.1| | 9 | ||
| – | PREDICTED: chaperone protein ClpB1-like [Glycine max] gi|356564815|ref|XP_003550643.1| | 12 | ||
| – | PREDICTED: chaperone protein ClpB1-like [Glycine max] gi|356564815|ref|XP_003550643.1| | 12 | ||
| – | ATP-dependent Clp protease ATP-binding subunit; TAIR: AT5G51070.1 Clp ATPase; Swiss-Prot: sp|P42762|CLPD_ARATH Chaperone protein ClpD, chloroplastic; TrEMBL-Plants: tr|I1JXT1|I1JXT1_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0330800 | 30 | ||
| – | ATP-dependent Clp protease ATP-binding subunit; TAIR: AT5G50920.1 CLPC homologue 1; Swiss-Prot: sp|P35100|CLPC_PEA Chaperone protein ClpC, chloroplastic; TrEMBL-Plants: tr|A0A0L9UEV5|A0A0L9UEV5_PHAAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0333900 | 32 | ||
| – | ATP-dependent Clp protease ATP-binding subunit; TAIR: AT5G50920.1 CLPC homologue 1; Swiss-Prot: sp|P35100|CLPC_PEA Chaperone protein ClpC, chloroplastic; TrEMBL-Plants: tr|I1JXP9|I1JXP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0333900 | 32 | ||
| – | ATP-dependent chaperone ClpB; TAIR: AT2G25140.1 casein lytic proteinase B4; Swiss-Prot: sp|Q8VYJ7|CLPB4_ARATH Chaperone protein ClpB4, mitochondrial; TrEMBL-Plants: tr|I1JU82|I1JU82_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0378600 | 34 | ||
| – | ATP-dependent chaperone ClpB; TAIR: AT5G15450.1 casein lytic proteinase B3; Swiss-Prot: sp|Q9LF37|CLPB3_ARATH Chaperone protein ClpB3, chloroplastic; TrEMBL-Plants: tr|A0A151TCE6|A0A151TCE6_CAJCA Chaperone protein clpB 2; Found in the gene: LotjaGi1g1v0509100 | 32 | ||
| – | Chaperone clpb, putative; TAIR: AT5G15450.1 casein lytic proteinase B3; Swiss-Prot: sp|Q9LF37|CLPB3_ARATH Chaperone protein ClpB3, chloroplastic; TrEMBL-Plants: tr|A0A1J7HJB5|A0A1J7HJB5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0509100 | 32 | ||
| – | ATP-dependent chaperone ClpB; TAIR: AT5G15450.1 casein lytic proteinase B3; Swiss-Prot: sp|Q9LF37|CLPB3_ARATH Chaperone protein ClpB3, chloroplastic; TrEMBL-Plants: tr|A0A072U702|A0A072U702_MEDTR Casein lytic proteinase B3; Found in the gene: LotjaGi1g1v0509100 | 32 | ||
| – | ATP-dependent chaperone ClpB; TAIR: AT5G15450.1 casein lytic proteinase B3; Swiss-Prot: sp|Q9LF37|CLPB3_ARATH Chaperone protein ClpB3, chloroplastic; TrEMBL-Plants: tr|A0A072U702|A0A072U702_MEDTR Casein lytic proteinase B3; Found in the gene: LotjaGi1g1v0509100 | 32 | ||
| – | ATP-dependent Clp protease ATP-binding subunit; TAIR: AT5G50920.1 CLPC homologue 1; Swiss-Prot: sp|P35100|CLPC_PEA Chaperone protein ClpC, chloroplastic; TrEMBL-Plants: tr|I1JXP9|I1JXP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0684200 | 32 | ||
| – | ATP-dependent Clp protease ATP-binding subunit ClpB; TAIR: AT5G50920.1 CLPC homologue 1; Swiss-Prot: sp|P35100|CLPC_PEA Chaperone protein ClpC, chloroplastic; TrEMBL-Plants: tr|A0A1J7GIN0|A0A1J7GIN0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi1g1v0684200 | 32 | ||
| – | ATP-dependent Clp protease ATP-binding subunit; TAIR: AT5G50920.1 CLPC homologue 1; Swiss-Prot: sp|P35100|CLPC_PEA Chaperone protein ClpC, chloroplastic; TrEMBL-Plants: tr|I1JXP9|I1JXP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0684200 | 32 | ||
| – | ATP-dependent Clp protease ATP-binding subunit; TAIR: AT5G50920.1 CLPC homologue 1; Swiss-Prot: sp|P35100|CLPC_PEA Chaperone protein ClpC, chloroplastic; TrEMBL-Plants: tr|I1JXP9|I1JXP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0684200 | 32 | ||
| – | ATP-dependent Clp protease ATP-binding subunit; TAIR: AT5G50920.1 CLPC homologue 1; Swiss-Prot: sp|P35100|CLPC_PEA Chaperone protein ClpC, chloroplastic; TrEMBL-Plants: tr|I1JXP9|I1JXP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0684200 | 32 | ||
| – | ATP-dependent clp protease, putative; TAIR: AT4G25370.1 Double Clp-N motif protein; Swiss-Prot: sp|Q93WL3|CLPT1_ARATH ATP-dependent Clp protease ATP-binding subunit CLPT1, chloroplastic; TrEMBL-Plants: tr|K7MIQ9|K7MIQ9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0160100 | 8 | ||
| – | ATP-dependent chaperone ClpB; TAIR: AT5G15450.1 casein lytic proteinase B3; Swiss-Prot: sp|Q9LF37|CLPB3_ARATH Chaperone protein ClpB3, chloroplastic; TrEMBL-Plants: tr|G7KLS1|G7KLS1_MEDTR Chaperone protein ClpB3; Found in the gene: LotjaGi2g1v0264100 | 32 | ||
| – | ATP-dependent chaperone ClpB; TAIR: AT5G15450.1 casein lytic proteinase B3; Swiss-Prot: sp|Q9LF37|CLPB3_ARATH Chaperone protein ClpB3, chloroplastic; TrEMBL-Plants: tr|G7KLS1|G7KLS1_MEDTR Chaperone protein ClpB3; Found in the gene: LotjaGi2g1v0264100 | 32 | ||
| – | ATP-dependent chaperone ClpB; TAIR: AT5G15450.1 casein lytic proteinase B3; Swiss-Prot: sp|Q9LF37|CLPB3_ARATH Chaperone protein ClpB3, chloroplastic; TrEMBL-Plants: tr|G7KLS1|G7KLS1_MEDTR Chaperone protein ClpB3; Found in the gene: LotjaGi2g1v0264100 | 32 | ||
| – | ATP-dependent chaperone ClpB; TAIR: AT5G15450.1 casein lytic proteinase B3; Swiss-Prot: sp|Q9LF37|CLPB3_ARATH Chaperone protein ClpB3, chloroplastic; TrEMBL-Plants: tr|G7KLS1|G7KLS1_MEDTR Chaperone protein ClpB3; Found in the gene: LotjaGi2g1v0264100 | 32 | ||
| – | ATP-dependent chaperone ClpB; TAIR: AT5G15450.1 casein lytic proteinase B3; Swiss-Prot: sp|Q9LF37|CLPB3_ARATH Chaperone protein ClpB3, chloroplastic; TrEMBL-Plants: tr|G7KLS1|G7KLS1_MEDTR Chaperone protein ClpB3; Found in the gene: LotjaGi2g1v0264100 | 32 | ||
| – | ATP-dependent Clp protease; TAIR: AT4G12060.1 Double Clp-N motif protein; Swiss-Prot: sp|Q8GW78|CLPT2_ARATH ATP-dependent Clp protease ATP-binding subunit CLPT2, chloroplastic; TrEMBL-Plants: tr|I3SMJ9|I3SMJ9_LOTJA Uncharacterized protein; Found in the gene: LotjaGi2g1v0427900 | 8 | ||
| – | Chaperone clpb, putative; TAIR: AT1G74310.1 heat shock protein 101; Swiss-Prot: sp|P42730|CLPB1_ARATH Chaperone protein ClpB1; TrEMBL-Plants: tr|A0A1J7I0F2|A0A1J7I0F2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0253800 | 30 | ||
| – | ATP-dependent chaperone ClpB; TAIR: AT1G74310.1 heat shock protein 101; Swiss-Prot: sp|P42730|CLPB1_ARATH Chaperone protein ClpB1; TrEMBL-Plants: tr|A0A1J7I0F2|A0A1J7I0F2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0253800 | 22 | ||
| – | Chaperone clpb, putative; TAIR: AT1G74310.1 heat shock protein 101; Swiss-Prot: sp|P42730|CLPB1_ARATH Chaperone protein ClpB1; TrEMBL-Plants: tr|A0A1J7I0F2|A0A1J7I0F2_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0253800 | 30 | ||
| – | ATP-dependent Clp protease ATP-binding subunit; TAIR: AT5G50920.1 CLPC homologue 1; Swiss-Prot: sp|P35100|CLPC_PEA Chaperone protein ClpC, chloroplastic; TrEMBL-Plants: tr|I1JXP9|I1JXP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0421200 | 37 | ||
| – | ATP-dependent Clp protease ATP-binding subunit; TAIR: AT5G50920.1 CLPC homologue 1; Swiss-Prot: sp|P35100|CLPC_PEA Chaperone protein ClpC, chloroplastic; TrEMBL-Plants: tr|I1JXP9|I1JXP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0421200 | 37 | ||
| – | ATP-dependent Clp protease ATP-binding subunit; TAIR: AT5G50920.1 CLPC homologue 1; Swiss-Prot: sp|P35100|CLPC_PEA Chaperone protein ClpC, chloroplastic; TrEMBL-Plants: tr|I1JXP9|I1JXP9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0421200 | 37 | ||
| – | ATP-dependent Clp protease ATP-binding subunit ClpB; TAIR: AT5G50920.1 CLPC homologue 1; Swiss-Prot: sp|P35100|CLPC_PEA Chaperone protein ClpC, chloroplastic; TrEMBL-Plants: tr|A0A1J7GIN0|A0A1J7GIN0_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0421200 | 37 | ||
| – | Chaperone protein clpB; TAIR: AT3G52490.1 Double Clp-N motif-containing P-loop nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9SVD0|SMXL3_ARATH Protein SMAX1-LIKE 3; TrEMBL-Plants: tr|A0A0S3SUQ6|A0A0S3SUQ6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0103200 | 12 | ||
| – | Chaperone protein clpB; TAIR: AT3G52490.1 Double Clp-N motif-containing P-loop nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9SVD0|SMXL3_ARATH Protein SMAX1-LIKE 3; TrEMBL-Plants: tr|A0A0S3SUQ6|A0A0S3SUQ6_PHAAN Uncharacterized protein; Found in the gene: LotjaGi5g1v0103200 | 12 | ||
| – | Chaperone protein ClpB; TAIR: AT3G52490.1 Double Clp-N motif-containing P-loop nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9SVD0|SMXL3_ARATH Protein SMAX1-LIKE 3; TrEMBL-Plants: tr|V7BFA4|V7BFA4_PHAVU Uncharacterized protein; Found in the gene: LotjaGi5g1v0255200 | 10 | ||
| – | Chaperone protein ClpB; TAIR: AT4G29920.2 Double Clp-N motif-containing P-loop nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q9SZR3|SMXL4_ARATH Protein SMAX1-LIKE 4; TrEMBL-Plants: tr|V7AYX8|V7AYX8_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0234400 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| SSF81923 | SUPERFAMILY | 1 | 1.96 |