Your browser is unable to support new features implemented in HTML5 and CSS3 to render this site as intended. Your experience may suffer from functionality degradation but the site should remain usable. We strongly recommend the latest version of Google Chrome, OS X Safari or Mozilla Firefox. As Safari is bundled with OS X, if you are unable to upgrade to a newer version of OS X, we recommend using an open source browser. Dismiss message
IPR018117 is a DNA methylase, C-5 cytosine-specific, active site.
<p>C-5 cytosine-specific DNA methylases (C5 Mtase) are enzymes that specifically methylate the C-5 carbon of cytosines in DNA [[cite:PUB00001771], [cite:PUB00004446], [cite:PUB00003244]]. Such enzymes are found in the proteins described below.</p> <ul> <li>As a component of type II restriction-modification systems in prokaryotes and some bacteriophages. Such enzymes recognise a specific DNA sequence where they methylate a cytosine. In doing so, they protect DNA from cleavage by type II restriction enzymes that recognise the same sequence. The sequences of a large number of type II C-5 Mtases are known.</li> <li>In vertebrates, there are a number of C-5 Mtases that methylate CpG dinucleotides. The sequence of the mammalian enzyme is known.</li> </ul> <p>C-5 Mtases share a number of short conserved regions. This conserved region contains a conserved Pro-Cys dipeptide in which the cysteine has been shown to be involved in the catalytic mechanism; it appears to form a covalent intermediate with the C6 position of cytosine [[cite:PUB00000336]].</p>
This description is obtained from EB-eye REST.
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | PREDICTED: DNA (cytosine-5)-methyltransferase CMT2-like [Cicer arietinum] gi|502154028|ref|XP_004509555.1| | 33 | ||
| – | PREDICTED: DNA (cytosine-5)-methyltransferase CMT3-like isoform X2 [Cicer arietinum] gi|502164095|ref|XP_004513047.1| | 18 | ||
| – | PREDICTED: DNA (cytosine-5)-methyltransferase CMT3-like isoform X2 [Cicer arietinum] gi|502164095|ref|XP_004513047.1| | 25 | ||
| – | DNA (cytosine-5)-methyltransferase [Medicago truncatula] gi|357498929|ref|XP_003619753.1| | 25 | ||
| – | LINE-1 reverse transcriptase isogeny; TAIR: AT3G24255.7 RNA-directed DNA polymerase (reverse transcriptase)-related family protein; Swiss-Prot: sp|P0C2F6|RNHX1_ARATH Putative ribonuclease H protein At1g65750; TrEMBL-Plants: tr|A0A151QR03|A0A151QR03_CAJCA Transposon TX1 uncharacterized; Found in the gene: LotjaGi1g1v0153100_LC | 11 | ||
| – | Cytosine-specific methyltransferase; TAIR: AT5G49160.1 methyltransferase 1; Swiss-Prot: sp|P34881|DNMT1_ARATH DNA (cytosine-5)-methyltransferase 1; TrEMBL-Plants: tr|I1JXB2|I1JXB2_SOYBN Cytosine-specific methyltransferase; Found in the gene: LotjaGi2g1v0168300 | 29 | ||
| – | Cytosine-specific methyltransferase; TAIR: AT5G49160.1 methyltransferase 1; Swiss-Prot: sp|P34881|DNMT1_ARATH DNA (cytosine-5)-methyltransferase 1; TrEMBL-Plants: tr|I1KCC0|I1KCC0_SOYBN Cytosine-specific methyltransferase; Found in the gene: LotjaGi2g1v0168300 | 29 | ||
| – | Cytosine-specific methyltransferase; TAIR: AT1G69770.1 chromomethylase 3; Swiss-Prot: sp|Q94F88|CMT3_ARATH DNA (cytosine-5)-methyltransferase CMT3; TrEMBL-Plants: tr|K7K149|K7K149_SOYBN Cytosine-specific methyltransferase; Found in the gene: LotjaGi2g1v0224800 | 36 | ||
| – | Cytosine-specific methyltransferase; TAIR: AT5G49160.1 methyltransferase 1; Swiss-Prot: sp|P34881|DNMT1_ARATH DNA (cytosine-5)-methyltransferase 1; TrEMBL-Plants: tr|I1JXB2|I1JXB2_SOYBN Cytosine-specific methyltransferase; Found in the gene: LotjaGi3g1v0150100 | 29 | ||
| – | Cytosine-specific methyltransferase; TAIR: AT5G49160.1 methyltransferase 1; Swiss-Prot: sp|P34881|DNMT1_ARATH DNA (cytosine-5)-methyltransferase 1; TrEMBL-Plants: tr|I1KCC0|I1KCC0_SOYBN Cytosine-specific methyltransferase; Found in the gene: LotjaGi3g1v0150100 | 29 | ||
| – | Cytosine-specific methyltransferase; TAIR: AT4G19020.1 chromomethylase 2; Swiss-Prot: sp|Q94F87|CMT2_ARATH DNA (cytosine-5)-methyltransferase CMT2; TrEMBL-Plants: tr|A0A0B2PQY3|A0A0B2PQY3_GLYSO Cytosine-specific methyltransferase; Found in the gene: LotjaGi4g1v0146500 | 32 | ||
| – | Cytosine-specific methyltransferase; TAIR: AT4G19020.1 chromomethylase 2; Swiss-Prot: sp|Q94F87|CMT2_ARATH DNA (cytosine-5)-methyltransferase CMT2; TrEMBL-Plants: tr|A0A0B2PQY3|A0A0B2PQY3_GLYSO Cytosine-specific methyltransferase; Found in the gene: LotjaGi4g1v0146500 | 32 | ||
| – | LINE-1 reverse transcriptase like; TAIR: AT3G24255.7 RNA-directed DNA polymerase (reverse transcriptase)-related family protein; Swiss-Prot: sp|P0C2F6|RNHX1_ARATH Putative ribonuclease H protein At1g65750; TrEMBL-Plants: tr|A0A151QR03|A0A151QR03_CAJCA Transposon TX1 uncharacterized; Found in the gene: LotjaGi4g1v0243500_LC | 10 | ||
| – | Cytosine-specific methyltransferase; TAIR: AT1G69770.1 chromomethylase 3; Swiss-Prot: sp|Q94F88|CMT3_ARATH DNA (cytosine-5)-methyltransferase CMT3; TrEMBL-Plants: tr|K7K149|K7K149_SOYBN Cytosine-specific methyltransferase; Found in the gene: LotjaGi4g1v0407700 | 35 | ||
| – | Cytosine-specific methyltransferase; TAIR: AT5G49160.1 methyltransferase 1; Swiss-Prot: sp|Q7Y1I7|DNM1A_ORYSJ DNA (cytosine-5)-methyltransferase 1A; TrEMBL-Plants: tr|A0A0B2RC49|A0A0B2RC49_GLYSO Cytosine-specific methyltransferase; Found in the gene: LotjaGi5g1v0197200 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| TIGR00675 | TIGRFAM | 1 | 6.67 |