Description

IPR001525 is a C-5 cytosine methyltransferase.

<p>C-5 cytosine-specific DNA methylases ([ec:2.1.1.37]) (C5 Mtase) are enzymes that specifically methylate the C-5 carbon of cytosines in DNA to produce C5-methylcytosine [[cite:PUB00001771], [cite:PUB00004446], [cite:PUB00003244]]. In mammalian cells, cytosine-specific methyltransferases methylate certain CpG sequences, which are believed to modulate gene expression and cell differentiation. In bacteria, these enzymes are a component of restriction-modification systems and serve as valuable tools for the manipulation of DNA [[cite:PUB00001090], [cite:PUB00004446]]. The structure of HhaI methyltransferase (M.HhaI) has been resolved to 2.5 A [[cite:PUB00000896]]: the molecule folds into 2 domains - a larger catalytic domain containing catalytic and cofactor binding sites, and a smaller DNA recognition domain.</p> <p>This entry also includes tRNA (cytosine(38)-C(5))-methyltransferase ([ec:2.1.1.204]), also known as DNMT2 (DNA (cytosine-5)-methyltransferase-like protein 2), that specifically methylates cytosine 38 in the anticodon loop of tRNA (Asp) [[cite:PUB00058132]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 29

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: