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IPR001223 is a Glycoside hydrolase family 18, catalytic domain.
<p>The glycosyl hydrolases family 18 (GH18) [cazy:GH18] is widely distributed in all kingdoms and contains hydrolytic enzymes with chitinase or endo-N-acetyl-beta-D-glucosaminidase (ENGase) activity as well as chitinase-like lectins (chi-lectins/proteins (CLPs). Chitinases ([ec:3.2.1.14]) are hydrolytic enzymes that cleave the beta-1,4-bond releasing oligomeric, dimeric (chitobiose) or monomeric (N-actetylglucosamine, GlcNAc) products. ENGases ([ec:3.2.1.96]) hydrolyze the beta-1,4 linkage in the chitobiose core of N-linked glycans from glycoproteins leaving one GlcNAc residue on the substrate. CLPs do not display chitinase activity but some of them have been reported to have specific functions and carbohydrate binding property [[cite:PUB00084156]]. This family also includes glycoproteins from mammals, such as oviduct-specific glycoproteins.</p> <p>This entry represents the catalytic domain of GH18s, which has a common (β/α)8 triosephosphate isomerase (TIM)-barrel structure that consists of a barrel-like framework made from eight internal parallel β-strands that are alternately connected by eight exterior α-helices. The active site motif DxxDxDxE is essential for the activity of the GH18 catalytic domain. [[cite:PUB00061053], [cite:PUB00093760], [cite:PUB00093762]].</p> <p>O-Glycosyl hydrolases ([ec:3.2.1.]) are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycosyl hydrolases, based on sequence similarity, has led to the definition of 85 different families [[cite:PUB00004870], [cite:PUB00005266]]. This classification is available on the CAZy (CArbohydrate-Active EnZymes) website.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
| GO term | Namespace | Name | Definition | Relationships |
|---|---|---|---|---|
| Biological process | Carbohydrate metabolic process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule. |
| Transcript | Name | Description | Predicted domains | Domain count |
|---|---|---|---|---|
| – | Chain A, Crystal Structure Of Tamarind Chitinase Like Lectin (tcll)gi|512125378|pdb|4B16|A Chain A, Crystal Structure Of Tamarind Chitinase Like Lectin (tcll) Complexed With N-acetyl Glucosamine (glcnac)] gi|512125377|pdb|4B15|A | 17 | ||
| – | PREDICTED: receptor-like serine/threonine-protein kinase SD1-6-like [Fragaria vesca subsp]. vesca] gi|470104631|ref|XP_004288701.1| | 17 | ||
| – | PREDICTED: acidic mammalian chitinase-like [Glycine max] gi|356565125|ref|XP_003550795.1| | 19 | ||
| – | PREDICTED: chitotriosidase-1-like [Glycine max] gi|356556606|ref|XP_003546615.1| | 23 | ||
| – | 21 | |||
| – | PREDICTED: G-type lectin S-receptor-like serine/threonine-protein kinase At1g11410-like, partial [Vitis vinifera] gi|359497026|ref|XP_003635401.1| | 29 | ||
| – | PREDICTED: chitinase domain-containing protein 1-like isoform X1 [Cicer arietinum] gi|502161879|ref|XP_004512315.1| | 7 | ||
| – | PREDICTED: chitinase domain-containing protein 1-like isoform X1 [Cicer arietinum] gi|502161879|ref|XP_004512315.1| | 15 | ||
| – | PREDICTED: acidic endochitinase [Vitis vinifera] gi|225454383|ref|XP_002279147.1| | 17 | ||
| – | PREDICTED: acidic endochitinase [Vitis vinifera] gi|225454383|ref|XP_002279147.1| | 17 | ||
| – | PREDICTED: acidic endochitinase-like [Cicer arietinum] gi|502094104|ref|XP_004490140.1| | 20 | ||
| – | Acidic endochitinase [Theobroma cacao] gi|508776152|gb|EOY23408.1| | 14 | ||
| – | Chitinase homologue [Sesbania rostrata] gi|2072742|emb|CAA88593.1| | 19 | ||
| – | PREDICTED: acidic endochitinase-like [Glycine max] gi|356535818|ref|XP_003536440.1| | 18 | ||
| – | Chitinase [Medicago truncatula] gi|357499923|ref|XP_003620250.1| | 10 | ||
| – | Chitinase [Medicago truncatula] gi|357499923|ref|XP_003620250.1| | 20 | ||
| – | PREDICTED: chitotriosidase-1-like [Cicer arietinum] gi|502125066|ref|XP_004498784.1| | 15 | ||
| – | PREDICTED: acidic mammalian chitinase-like [Glycine max] gi|356563922|ref|XP_003550206.1| | 13 | ||
| – | PREDICTED: acidic mammalian chitinase-like [Glycine max] gi|356563922|ref|XP_003550206.1| | 8 | ||
| – | PREDICTED: acidic mammalian chitinase-like [Glycine max] gi|356563922|ref|XP_003550206.1| | 11 | ||
| – | PREDICTED: acidic endochitinase-like [Glycine max] gi|356567519|ref|XP_003551966.1| | 20 | ||
| – | Chitinase [Medicago truncatula] gi|357443753|ref|XP_003592154.1| | 20 | ||
| – | PREDICTED: acidic endochitinase-like [Glycine max] gi|356535818|ref|XP_003536440.1| | 9 | ||
| – | PREDICTED: acidic mammalian chitinase-like [Cicer arietinum] gi|502131776|ref|XP_004501097.1| | 21 | ||
| – | 21 | |||
| – | Chitinase domain-containing protein 1; TAIR: AT4G01040.1 Glycosyl hydrolase superfamily protein; Swiss-Prot: sp|Q66IL0|CHID1_XENTR Chitinase domain-containing protein 1; TrEMBL-Plants: tr|G7K407|G7K407_MEDTR Glycoside hydrolase family 18 protein; Found in the gene: LotjaGi1g1v0635600 | 17 | ||
| – | Chitinase domain-containing protein 1; TAIR: AT4G01040.1 Glycosyl hydrolase superfamily protein; Swiss-Prot: sp|Q922Q9|CHID1_MOUSE Chitinase domain-containing protein 1; TrEMBL-Plants: tr|K7KH31|K7KH31_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0635600 | 9 | ||
| – | Chitinase domain-containing protein 1; TAIR: AT4G01040.1 Glycosyl hydrolase superfamily protein; Swiss-Prot: sp|Q68EX9|CHID1_XENLA Chitinase domain-containing protein 1; TrEMBL-Plants: tr|K7KH31|K7KH31_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0635600 | 9 | ||
| – | Acidic endochitinase; TAIR: AT5G24090.1 chitinase A; Swiss-Prot: sp|P23472|CHLY_HEVBR Hevamine-A; TrEMBL-Plants: tr|G7L2X2|G7L2X2_MEDTR Class III chitinase; Found in the gene: LotjaGi1g1v0788000 | 16 | ||
| – | Acidic endochitinase; TAIR: AT5G24090.1 chitinase A; Swiss-Prot: sp|P51614|CHIT3_VITVI Acidic endochitinase; TrEMBL-Plants: tr|B9I8R4|B9I8R4_POPTR Chitinase family protein; Found in the gene: LotjaGi1g1v0788000 | 16 | ||
| – | Acidic endochitinase; TAIR: AT5G24090.1 chitinase A; Swiss-Prot: sp|P23472|CHLY_HEVBR Hevamine-A; TrEMBL-Plants: tr|A0A0D2RDX8|A0A0D2RDX8_GOSRA Uncharacterized protein; Found in the gene: LotjaGi1g1v0788100 | 16 | ||
| – | Acidic endochitinase; TAIR: AT5G24090.1 chitinase A; Swiss-Prot: sp|P29024|CHIA_PHAAN Acidic endochitinase; TrEMBL-Plants: tr|A0A151S757|A0A151S757_CAJCA Acidic endochitinase; Found in the gene: LotjaGi2g1v0137400 | 16 | ||
| – | Acidic endochitinase; TAIR: AT5G24090.1 chitinase A; Swiss-Prot: sp|P29024|CHIA_PHAAN Acidic endochitinase; TrEMBL-Plants: tr|I1N156|I1N156_SOYBN Uncharacterized protein; Found in the gene: LotjaGi2g1v0223200 | 18 | ||
| – | Acidic endochitinase; TAIR: AT5G24090.1 chitinase A; Swiss-Prot: sp|P29024|CHIA_PHAAN Acidic endochitinase; TrEMBL-Plants: tr|G7JXV4|G7JXV4_MEDTR Chitinase; Found in the gene: LotjaGi2g1v0297900 | 18 | ||
| – | Chitinase; TAIR: AT4G19800.1 Glycosyl hydrolase family protein with chitinase insertion domain-containing protein; Swiss-Prot: sp|Q7M443|CHIT2_TULBA Chitinase 2; TrEMBL-Plants: tr|A0A0L9V6Z7|A0A0L9V6Z7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0366100 | 18 | ||
| – | Chitinase; TAIR: AT4G19720.1 Glycosyl hydrolase family protein with chitinase insertion domain-containing protein; Swiss-Prot: sp|Q7M443|CHIT2_TULBA Chitinase 2; TrEMBL-Plants: tr|A0A0L9V6Z7|A0A0L9V6Z7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0366300 | 18 | ||
| – | Chitinase; TAIR: AT4G19810.1 Glycosyl hydrolase family protein with chitinase insertion domain-containing protein; Swiss-Prot: sp|Q91XA9|CHIA_MOUSE Acidic mammalian chitinase; TrEMBL-Plants: tr|A0A1B1J8W5|A0A1B1J8W5_MEDTR Class V chitinase b protein; Found in the gene: LotjaGi4g1v0284200 | 21 | ||
| – | Receptor protein kinase, putative; TAIR: AT4G23200.1 cysteine-rich RLK (RECEPTOR-like protein kinase) 12; Swiss-Prot: sp|O65472|CRK12_ARATH Putative cysteine-rich receptor-like protein kinase 12; TrEMBL-Plants: tr|A0A072US50|A0A072US50_MEDTR Cysteine-rich RLK (Receptor-like kinase) protein; Found in the gene: LotjaGi4g1v0284300 | 36 | ||
| – | Receptor protein kinase, putative; TAIR: AT1G11330.1 S-locus lectin protein kinase family protein; Swiss-Prot: sp|Q9SXB8|Y1133_ARATH G-type lectin S-receptor-like serine/threonine-protein kinase At1g11330; TrEMBL-Plants: tr|A0A151QSL2|A0A151QSL2_CAJCA Cysteine-rich receptor-like protein kinase 10; Found in the gene: LotjaGi4g1v0284600 | 35 | ||
| – | Chitinase, putative; TAIR: AT4G19810.1 Glycosyl hydrolase family protein with chitinase insertion domain-containing protein; Swiss-Prot: sp|Q13231|CHIT1_HUMAN Chitotriosidase-1; TrEMBL-Plants: tr|A0A1J7GHK5|A0A1J7GHK5_LUPAN Uncharacterized protein; Found in the gene: LotjaGi4g1v0284700 | 21 | ||
| – | Chitinase; TAIR: AT4G19810.1 Glycosyl hydrolase family protein with chitinase insertion domain-containing protein; Swiss-Prot: sp|Q9W5U2|CHIT3_DROME Probable chitinase 3; TrEMBL-Plants: tr|A0A1B1J8Z2|A0A1B1J8Z2_LOTJA Class V chitinase protein; Found in the gene: LotjaGi5g1v0054700 | 10 | ||
| – | Chitinase, putative; TAIR: AT4G19810.1 Glycosyl hydrolase family protein with chitinase insertion domain-containing protein; Swiss-Prot: sp|Q13231|CHIT1_HUMAN Chitotriosidase-1; TrEMBL-Plants: tr|A0A1B1J8Z2|A0A1B1J8Z2_LOTJA Class V chitinase protein; Found in the gene: LotjaGi5g1v0054800 | 21 | ||
| – | Chitinase; TAIR: AT4G19810.1 Glycosyl hydrolase family protein with chitinase insertion domain-containing protein; Swiss-Prot: sp|Q9W5U2|CHIT3_DROME Probable chitinase 3; TrEMBL-Plants: tr|A0A1B1J8Z2|A0A1B1J8Z2_LOTJA Class V chitinase protein; Found in the gene: LotjaGi5g1v0055200 | 12 | ||
| – | Acidic endochitinase; TAIR: AT5G24090.1 chitinase A; Swiss-Prot: sp|P36908|CHIA_CICAR Acidic endochitinase; TrEMBL-Plants: tr|I3SK63|I3SK63_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0294000 | 18 | ||
| – | Acidic chitinase; TAIR: AT5G24090.1 chitinase A; Swiss-Prot: sp|P29024|CHIA_PHAAN Acidic endochitinase; TrEMBL-Plants: tr|Q41401|Q41401_SESRO Chitinase homologue; Found in the gene: LotjaGi5g1v0294100 | 18 | ||
| – | Acidic endochitinase; TAIR: AT5G24090.1 chitinase A; Swiss-Prot: sp|P19172|CHIA_ARATH Acidic endochitinase; TrEMBL-Plants: tr|I3S5N5|I3S5N5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0294200 | 18 | ||
| – | Acidic endochitinase; TAIR: AT5G24090.1 chitinase A; Swiss-Prot: sp|P51614|CHIT3_VITVI Acidic endochitinase; TrEMBL-Plants: tr|I3S5N5|I3S5N5_LOTJA Uncharacterized protein; Found in the gene: LotjaGi5g1v0294200 | 15 | ||
| – | Chitinase; TAIR: AT4G19810.1 Glycosyl hydrolase family protein with chitinase insertion domain-containing protein; Swiss-Prot: sp|Q13231|CHIT1_HUMAN Chitotriosidase-1; TrEMBL-Plants: tr|I3S8H4|I3S8H4_LOTJA Uncharacterized protein; Found in the gene: LotjaGi6g1v0206300 | 21 |
A list of co-occurring predicted domains within the L. japonicus gene space:
| Predicted domain | Source | Observations | Saturation (%) |
|---|---|---|---|
| cd02879 | CDD | 1 | 2.08 |