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IPR009008

Source: InterPro

Description

IPR009008 is a Valyl/Leucyl/Isoleucyl-tRNA synthetase, editing domain.

<p>Certain aminoacyl-tRNA synthetases prevent potential errors in protein synthesis through deacylation of mischarged tRNAs. The close homologues isoleucyl-tRNA synthetase (IleRS) and valyl-tRNA synthetase (ValRS) deacylate Val-tRNAIle and Thr-tRNAVal, respectively. These reactions strictly require the presence of the cognate tRNA. In the absence of tRNA, the enzymatically generated misactivated adenylates remain in the active site, sequestered from hydrolysis. Upon addition of cognate tRNA the misactivated amino acids are hydrolysed, regenerating the free tRNA and amino acid, while converting 1 equivalent of ATP to AMP. A prominent mechanism for editing misactivated amino acids is the rapid hydrolysis of transiently mischarged tRNA. This reaction is catalysed at a second active site on IleRS and ValRS. This site is located within a large insertion (termed CP1) into the canonical class I aminoacyl-tRNA synthetase active-site fold [[cite:PUB00038093], [cite:PUB00065057]]. The CP1 domain as an isolated polypeptide hydrolyses its cognate mischarged tRNA [[cite:PUB00011778]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .

GO term Namespace Name Definition Relationships
GO:0002161
Molecular function Aminoacyl-tRNA editing activity The hydrolysis of an incorrectly aminoacylated tRNA.
Subterm of
GO:0006418
Biological process TRNA aminoacylation for protein translation The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA and the alpha carboxylic acid group of an amino acid, to be used in ribosome-mediated polypeptide synthesis.
Subterm of
Part of

Associated Lotus transcripts 43

Transcript Name Description Predicted domains Domain count
Lj0g3v0063869.1
– PREDICTED: valine--tRNA ligase-like [Cicer arietinum] gi|502091866|ref|XP_004489655.1|
Domains
14
Lj1g3v3137930.1
– PREDICTED: leucyl-tRNA synthetase, cytoplasmic-like [Glycine max] gi|356497127|ref|XP_003517414.1|
Domains
24
Lj1g3v3918090.1
– PREDICTED: leucine--tRNA ligase, cytoplasmic-like isoform X2 [Cicer arietinum] gi|502147205|ref|XP_004506692.1|
Domains
10
Lj1g3v3918100.1
– PREDICTED: leucine--tRNA ligase, cytoplasmic-like isoform X2 [Cicer arietinum] gi|502147205|ref|XP_004506692.1|
Domains
5
Lj2g3v0911740.1
– PREDICTED: leucine--tRNA ligase, cytoplasmic-like isoform X1 [Cicer arietinum] gi|502147203|ref|XP_004506691.1|
Domains
5
Lj3g3v3032100.1
– PREDICTED: leucine--tRNA ligase, cytoplasmic-like isoform X1 [Cicer arietinum] gi|502147203|ref|XP_004506691.1|
Domains
23
Lj3g3v3032100.2
– PREDICTED: leucyl-tRNA synthetase, cytoplasmic-like [Glycine max] gi|356497127|ref|XP_003517414.1|
Domains
23
Lj3g3v3032100.3
– PREDICTED: leucyl-tRNA synthetase, cytoplasmic-like [Glycine max] gi|356497127|ref|XP_003517414.1|
Domains
20
Lj3g3v3599450.1
– PREDICTED: isoleucine--tRNA ligase, cytoplasmic-like [Cicer arietinum] gi|502144299|ref|XP_004505648.1|
Domains
24
Lj4g3v0134610.1
– PREDICTED: leucyl-tRNA synthetase-like [Glycine max] gi|356522021|ref|XP_003529648.1|
Domains
14
Lj4g3v0134610.2
– PREDICTED: leucyl-tRNA synthetase-like [Glycine max] gi|356522021|ref|XP_003529648.1|
Domains
35
Lj4g3v0134610.3
– PREDICTED: leucyl-tRNA synthetase-like [Glycine max] gi|356522021|ref|XP_003529648.1|
Domains
34
Lj5g3v2028360.1
– PREDICTED: valyl-tRNA synthetase-like isoform 1 [Glycine max] gi|356535908|ref|XP_003536484.1|
Domains
16
Lj5g3v2028360.2
– PREDICTED: valyl-tRNA synthetase-like isoform 1 [Glycine max] gi|356535908|ref|XP_003536484.1|
Domains
21
Lj6g3v0819090.1
– PREDICTED: leucyl-tRNA synthetase, cytoplasmic-like [Glycine max] gi|356497127|ref|XP_003517414.1|
Domains
23
Lj6g3v1445620.1
– PREDICTED: isoleucine--tRNA ligase-like [Cicer arietinum] gi|502085158|ref|XP_004487851.1|
Domains
28
LotjaGi1g1v0529100.1
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0529100
Domains
21
LotjaGi1g1v0529100.2
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0529100
Domains
20
LotjaGi1g1v0635300_LC.1
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|A0A0B2SEG7|A0A0B2SEG7_GLYSO Leucine--tRNA ligase, cytoplasmic; Found in the gene: LotjaGi1g1v0635300_LC
Domains
6
LotjaGi2g1v0111300.1
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
Domains
27
LotjaGi2g1v0111300.2
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
Domains
31
LotjaGi2g1v0111300.3
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
Domains
27
LotjaGi2g1v0111300.4
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
Domains
31
LotjaGi2g1v0111300.5
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
Domains
28
LotjaGi2g1v0111300.6
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
Domains
31
LotjaGi2g1v0111300.7
– Valine--tRNA ligase; TAIR: AT5G16715.1 protein EMBRYO DEFECTIVE 2247; Swiss-Prot: sp|F4KE63|SYVM2_ARATH Valine--tRNA ligase, chloroplastic/mitochondrial 2; TrEMBL-Plants: tr|A0A0B2SHS3|A0A0B2SHS3_GLYSO Valine--tRNA ligase; Found in the gene: LotjaGi2g1v0111300
Domains
31
LotjaGi3g1v0484200.2
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0484200
Domains
20
LotjaGi3g1v0484200.3
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0484200
Domains
20
LotjaGi3g1v0535700.1
– Isoleucine-tRNA ligase; TAIR: AT4G10320.1 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|F4JLM5|SYIC_ARATH Isoleucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|A0A0S3SEB7|A0A0S3SEB7_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0535700
Domains
23
LotjaGi4g1v0011900.1
– Leucine--tRNA ligase; TAIR: AT4G04350.1 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q9XEA0|SYLM_ARATH Leucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7JJA8|G7JJA8_MEDTR Leucyl-tRNA synthetase; Found in the gene: LotjaGi4g1v0011900
Domains
35
LotjaGi4g1v0011900.2
– Leucine--tRNA ligase; TAIR: AT4G04350.1 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q9XEA0|SYLM_ARATH Leucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|G7JJA8|G7JJA8_MEDTR Leucyl-tRNA synthetase; Found in the gene: LotjaGi4g1v0011900
Domains
35
LotjaGi4g1v0011900.3
– Leucine--tRNA ligase; TAIR: AT4G04350.1 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q9XEA0|SYLM_ARATH Leucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|I1KNG6|I1KNG6_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0011900
Domains
29
LotjaGi5g1v0305000.1
– Valine--tRNA ligase; TAIR: AT1G14610.1 valyl-tRNA synthetase / valine-tRNA ligase (VALRS); Swiss-Prot: sp|P93736|SYVM1_ARATH Valine--tRNA ligase, mitochondrial 1; TrEMBL-Plants: tr|A0A151U9X6|A0A151U9X6_CAJCA Valyl-tRNA synthetase; Found in the gene: LotjaGi5g1v0305000
Domains
27
LotjaGi5g1v0305000.2
– Valine--tRNA ligase; TAIR: AT1G14610.1 valyl-tRNA synthetase / valine-tRNA ligase (VALRS); Swiss-Prot: sp|P93736|SYVM1_ARATH Valine--tRNA ligase, mitochondrial 1; TrEMBL-Plants: tr|A0A151U9X6|A0A151U9X6_CAJCA Valyl-tRNA synthetase; Found in the gene: LotjaGi5g1v0305000
Domains
27
LotjaGi5g1v0305000.3
– Valine--tRNA ligase; TAIR: AT1G14610.1 valyl-tRNA synthetase / valine-tRNA ligase (VALRS); Swiss-Prot: sp|P93736|SYVM1_ARATH Valine--tRNA ligase, mitochondrial 1; TrEMBL-Plants: tr|A0A151U9X6|A0A151U9X6_CAJCA Valyl-tRNA synthetase; Found in the gene: LotjaGi5g1v0305000
Domains
33
LotjaGi5g1v0305000.4
– Valine--tRNA ligase; TAIR: AT1G14610.1 valyl-tRNA synthetase / valine-tRNA ligase (VALRS); Swiss-Prot: sp|P93736|SYVM1_ARATH Valine--tRNA ligase, mitochondrial 1; TrEMBL-Plants: tr|A0A151U9X6|A0A151U9X6_CAJCA Valyl-tRNA synthetase; Found in the gene: LotjaGi5g1v0305000
Domains
26
LotjaGi6g1v0153700.1
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0153700
Domains
20
LotjaGi6g1v0153700.2
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0153700
Domains
20
LotjaGi6g1v0153700.3
– Leucine--tRNA ligase; TAIR: AT1G09620.1 ATP binding/leucine-tRNA ligases/aminoacyl-tRNA ligase; Swiss-Prot: sp|F4I116|SYLC_ARATH Leucine--tRNA ligase, cytoplasmic; TrEMBL-Plants: tr|I1J9U5|I1J9U5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0153700
Domains
20
LotjaGi6g1v0249900.1
– Isoleucine-tRNA ligase; TAIR: AT5G49030.3 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q8RXK8|SYIM_ARATH Isoleucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072V611|A0A072V611_MEDTR Isoleucine-tRNA ligase; Found in the gene: LotjaGi6g1v0249900
Domains
29
LotjaGi6g1v0249900.2
– Isoleucine-tRNA ligase; TAIR: AT5G49030.3 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q8RXK8|SYIM_ARATH Isoleucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072V611|A0A072V611_MEDTR Isoleucine-tRNA ligase; Found in the gene: LotjaGi6g1v0249900
Domains
28
LotjaGi6g1v0249900.3
– Isoleucine-tRNA ligase; TAIR: AT5G49030.3 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q8RXK8|SYIM_ARATH Isoleucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072V611|A0A072V611_MEDTR Isoleucine-tRNA ligase; Found in the gene: LotjaGi6g1v0249900
Domains
27
LotjaGi6g1v0249900.4
– Isoleucine-tRNA ligase; TAIR: AT5G49030.3 tRNA synthetase class I (I, L, M and V) family protein; Swiss-Prot: sp|Q8RXK8|SYIM_ARATH Isoleucine--tRNA ligase, chloroplastic/mitochondrial; TrEMBL-Plants: tr|A0A072V611|A0A072V611_MEDTR Isoleucine-tRNA ligase; Found in the gene: LotjaGi6g1v0249900
Domains
29

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space:

Predicted domain Source Observations Saturation (%)
mobidb-lite MobiDBLite 1 2.33