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IPR033133 is a Pumilio homology domain.
<p>Members of the Pumilio family of proteins (Puf) regulate translation and mRNA stability in a wide variety of eukaryotic organisms including mammals, flies, worms, slime mold, and yeast [[cite:PUB00018238]]. Pumilio family members are characterised by the presence of eight tandem copies of an imperfectly repeated 36 amino acids sequence motif, the Pumilio repeat, surrounded by a short N- and C-terminal conserved region. The eight repeats and the N- and C-terminal regions form the Pumilio homology domain (PUM-HD). The PUM-HD domain is a sequence-specific RNA binding domain. Several Puf members have been shown to bind specific RNA sequences mainly found in the 3' UTR of mRNA and repress their translation [[cite:PUB00018239]]. Frequently, Puf proteins function asymmetrically to create protein gradients, thus causing asymmetric cell division and regulating cell fate specification [[cite:PUB00018240]].</p> <p>Crystal structure of Pumilio repeats has been solved [[cite:PUB00018241]]. The PUM repeat with the N- and C-terminal regions pack together to form a right-handed superhelix that approximates a half doughnut structurally similar to the Armadillo (ARM) repeat proteins, beta-catenin and karyopherin alpha. The RNA binds the concave surface of the molecule, where each of the protein's eight repeats makes contacts with a different RNA base via three amino acid side chains at conserved positions [[cite:PUB00018242]].</p> <p>This entry represents the PUM-HD domain.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | RNA binding | Interacting selectively and non-covalently with an RNA molecule or a portion thereof. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | PREDICTED: pumilio homolog 1-like isoform X2 [Cicer arietinum] gi|502096967|ref|XP_004490876.1| | 17 | ||
– | PREDICTED: pumilio homolog 2-like [Cicer arietinum] gi|502081839|ref|XP_004486985.1| | 17 | ||
– | PREDICTED: pumilio homolog 2-like [Cicer arietinum] gi|502081839|ref|XP_004486985.1| | 17 | ||
– | PREDICTED: pumilio homolog 12-like [Cicer arietinum] gi|502132806|ref|XP_004501537.1| | 14 | ||
– | Pumilio-like protein [Medicago truncatula] gi|357454231|ref|XP_003597396.1| | 16 | ||
– | PREDICTED: pumilio homolog 11-like [Cicer arietinum] gi|502117968|ref|XP_004496035.1| | 10 | ||
– | PREDICTED: pumilio homolog 12-like [Cicer arietinum] gi|502132806|ref|XP_004501537.1| | 14 | ||
– | PREDICTED: LOW QUALITY PROTEIN: pumilio homolog 6, chloroplastic-like [Glycine max] gi|356550736|ref|XP_003543740.1| | 15 | ||
– | PREDICTED: pumilio homolog 24-like isoform 1 [Glycine max] gi|356564394|ref|XP_003550439.1| | 13 | ||
– | PREDICTED: pumilio homolog 4-like isoform X4 [Cicer arietinum] gi|502118396|ref|XP_004496246.1| | 17 | ||
– | PREDICTED: pumilio homolog 4-like isoform X5 [Cicer arietinum] gi|502118398|ref|XP_004496247.1| | 17 | ||
– | PREDICTED: pumilio homolog 5-like [Cicer arietinum] gi|502085772|ref|XP_004488002.1| | 15 | ||
– | PREDICTED: pumilio homolog 2-like [Glycine max] gi|356557551|ref|XP_003547079.1| | 15 | ||
– | Pumilio, putative; TAIR: AT2G29200.1 pumilio 1; Swiss-Prot: sp|Q9ZW07|PUM1_ARATH Pumilio homolog 1; TrEMBL-Plants: tr|V7B957|V7B957_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0088100 | 17 | ||
– | Pumilio, putative; TAIR: AT2G29200.1 pumilio 1; Swiss-Prot: sp|Q9ZW07|PUM1_ARATH Pumilio homolog 1; TrEMBL-Plants: tr|V7B957|V7B957_PHAVU Uncharacterized protein; Found in the gene: LotjaGi1g1v0088100 | 17 | ||
– | Pumilio; TAIR: AT1G22240.1 pumilio 8; Swiss-Prot: sp|Q9C9R6|PUM7_ARATH Putative pumilio homolog 7, chloroplastic; TrEMBL-Plants: tr|G7KAF0|G7KAF0_MEDTR Pumilio-family RNA-binding repeatprotein; Found in the gene: LotjaGi1g1v0146700 | 14 | ||
– | Pumilio-like protein; TAIR: AT5G56510.1 pumilio 12; Swiss-Prot: sp|Q9LVC3|PUM12_ARATH Pumilio homolog 12; TrEMBL-Plants: tr|K7KT25|K7KT25_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0359500 | 15 | ||
– | Pumilio-like protein; TAIR: AT2G29190.1 pumilio 2; Swiss-Prot: sp|Q9ZW06|PUM2_ARATH Pumilio homolog 2; TrEMBL-Plants: tr|I1MDC9|I1MDC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0285500 | 17 | ||
– | Pumilio-like protein; TAIR: AT2G29190.1 pumilio 2; Swiss-Prot: sp|Q9ZW06|PUM2_ARATH Pumilio homolog 2; TrEMBL-Plants: tr|I1MDC9|I1MDC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0285500 | 17 | ||
– | Pumilio-like protein; TAIR: AT2G29190.1 pumilio 2; Swiss-Prot: sp|Q9ZW06|PUM2_ARATH Pumilio homolog 2; TrEMBL-Plants: tr|I1MDC9|I1MDC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0285500 | 17 | ||
– | Pumilio-like protein; TAIR: AT2G29190.1 pumilio 2; Swiss-Prot: sp|Q9ZW06|PUM2_ARATH Pumilio homolog 2; TrEMBL-Plants: tr|A0A0B2RMP3|A0A0B2RMP3_GLYSO Pumilio like 2; Found in the gene: LotjaGi3g1v0285500 | 17 | ||
– | Pumilio-like protein; TAIR: AT2G29190.1 pumilio 2; Swiss-Prot: sp|Q9ZW06|PUM2_ARATH Pumilio homolog 2; TrEMBL-Plants: tr|I1MDC9|I1MDC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0285500 | 17 | ||
– | Pumilio-like protein; TAIR: AT2G29190.1 pumilio 2; Swiss-Prot: sp|Q9ZW06|PUM2_ARATH Pumilio homolog 2; TrEMBL-Plants: tr|A0A0B2RMP3|A0A0B2RMP3_GLYSO Pumilio like 2; Found in the gene: LotjaGi3g1v0285500 | 17 | ||
– | Pumilio-like protein; TAIR: AT2G29190.1 pumilio 2; Swiss-Prot: sp|Q9ZW06|PUM2_ARATH Pumilio homolog 2; TrEMBL-Plants: tr|I1MDC9|I1MDC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0285800 | 17 | ||
– | Pumilio-like protein; TAIR: AT2G29190.1 pumilio 2; Swiss-Prot: sp|Q9ZW06|PUM2_ARATH Pumilio homolog 2; TrEMBL-Plants: tr|I1MDC9|I1MDC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0285800 | 17 | ||
– | Pumilio-like protein; TAIR: AT2G29190.1 pumilio 2; Swiss-Prot: sp|Q9ZW06|PUM2_ARATH Pumilio homolog 2; TrEMBL-Plants: tr|I1MDC9|I1MDC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0285800 | 17 | ||
– | Pumilio-like protein; TAIR: AT2G29190.1 pumilio 2; Swiss-Prot: sp|Q9ZW06|PUM2_ARATH Pumilio homolog 2; TrEMBL-Plants: tr|A0A0B2RMP3|A0A0B2RMP3_GLYSO Pumilio like 2; Found in the gene: LotjaGi3g1v0285800 | 17 | ||
– | Pumilio-like protein; TAIR: AT2G29190.1 pumilio 2; Swiss-Prot: sp|Q9ZW06|PUM2_ARATH Pumilio homolog 2; TrEMBL-Plants: tr|I1MDC9|I1MDC9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0285800 | 17 | ||
– | Pumilio, putative; TAIR: AT4G25880.4 pumilio 6; Swiss-Prot: sp|Q9C5E7|PUM6_ARATH Pumilio homolog 6, chloroplastic; TrEMBL-Plants: tr|K7LWU3|K7LWU3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0304100 | 15 | ||
– | Pumilio, putative; TAIR: AT4G25880.1 pumilio 6; Swiss-Prot: sp|Q9C5E7|PUM6_ARATH Pumilio homolog 6, chloroplastic; TrEMBL-Plants: tr|K7LWU3|K7LWU3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0304100 | 15 | ||
– | Pumilio, putative; TAIR: AT4G25880.1 pumilio 6; Swiss-Prot: sp|Q9C5E7|PUM6_ARATH Pumilio homolog 6, chloroplastic; TrEMBL-Plants: tr|K7LWU3|K7LWU3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0304100 | 15 | ||
– | Pumilio-like protein; TAIR: AT3G16810.1 pumilio 24; Swiss-Prot: sp|Q9LRZ3|PUM24_ARATH Pumilio homolog 24; TrEMBL-Plants: tr|I1MRL9|I1MRL9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0337600 | 12 | ||
– | Pumilio-like protein; TAIR: AT3G16810.1 pumilio 24; Swiss-Prot: sp|Q9LRZ3|PUM24_ARATH Pumilio homolog 24; TrEMBL-Plants: tr|I1MRL9|I1MRL9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0337600 | 12 | ||
– | Pumilio-like protein; TAIR: AT3G16810.1 pumilio 24; Swiss-Prot: sp|Q9LRZ3|PUM24_ARATH Pumilio homolog 24; TrEMBL-Plants: tr|I1MRL9|I1MRL9_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0337600 | 12 | ||
– | Pumilio, putative; TAIR: AT3G10360.1 pumilio 4; Swiss-Prot: sp|Q9SS47|PUM4_ARATH Pumilio homolog 4; TrEMBL-Plants: tr|I1NHH7|I1NHH7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0271700 | 17 | ||
– | Pumilio, putative; TAIR: AT3G10360.1 pumilio 4; Swiss-Prot: sp|Q9SS47|PUM4_ARATH Pumilio homolog 4; TrEMBL-Plants: tr|I1NHH7|I1NHH7_SOYBN Uncharacterized protein; Found in the gene: LotjaGi5g1v0271700 | 17 | ||
– | Pumilio-like protein; TAIR: AT1G78160.1 pumilio 7; Swiss-Prot: sp|Q09829|YAD3_SCHPO Pumilio domain-containing protein C4G8.03c; TrEMBL-Plants: tr|V7BDT2|V7BDT2_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0217800_LC | 10 | ||
– | Pumilio, putative; TAIR: AT3G20250.2 pumilio 5; Swiss-Prot: sp|Q9LJX4|PUM5_ARATH Pumilio homolog 5; TrEMBL-Plants: tr|I1L1B8|I1L1B8_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0239800 | 15 | ||
– | Pumilio, putative; TAIR: AT3G20250.2 pumilio 5; Swiss-Prot: sp|Q9LJX4|PUM5_ARATH Pumilio homolog 5; TrEMBL-Plants: tr|A0A0B2RRT4|A0A0B2RRT4_GLYSO Pumilio like 5; Found in the gene: LotjaGi6g1v0239800 | 15 | ||
– | Pumilio; TAIR: AT1G78160.1 pumilio 7; Swiss-Prot: sp|Q9C9R6|PUM7_ARATH Putative pumilio homolog 7, chloroplastic; TrEMBL-Plants: tr|A0A0B2RFZ1|A0A0B2RFZ1_GLYSO Putative pumilio like 7, chloroplastic; Found in the gene: LotjaGi6g1v0353100 | 15 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
mobidb-lite | MobiDBLite | 1 | 2.50 |