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IPR001401 is a Dynamin, GTPase domain.
<p>Membrane transport between compartments in eukaryotic cells requires proteins that allow the budding and scission of nascent cargo vesicles from one compartment and their targeting and fusion with another. Dynamins are large GTPases that belong to a protein superfamily [[cite:PUB00014977]] that, in eukaryotic cells, includes classical dynamins, dynamin-like proteins, OPA1, Mx proteins, mitofusins and guanylate-binding proteins/atlastins [[cite:PUB00000075], [cite:PUB00000836], [cite:PUB00001910], [cite:PUB00003186], [cite:PUB00057048]], and are involved in the scission of a wide range of vesicles and organelles. They play a role in many processes including budding of transport vesicles, division of organelles, cytokinesis and pathogen resistance.</p> <p>The minimal distinguishing architectural features that are common to all dynamins and are distinct from other GTPases are the structure of the large GTPase domain (300 amino acids) and the presence of two additional domains; the middle domain and the GTPase effector domain (GED), which are involved in oligomerisation and regulation of the GTPase activity.</p> <p>This entry represents the GTPase domain, containing the GTP-binding motifs that are needed for guanine-nucleotide binding and hydrolysis. The conservation of these motifs is absolute except for the the final motif in guanylate-binding proteins. The GTPase catalytic activity can be stimulated by oligomerisation of the protein, which is mediated by interactions between the GTPase domain, the middle domain and the GED.</p>
This description is obtained from EB-eye REST.
GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on , while the GO metadata was last updated on .
GO term | Namespace | Name | Definition | Relationships |
---|---|---|---|---|
Molecular function | GTPase activity | Catalysis of the reaction: GTP + H2O = GDP + phosphate. | ||
Molecular function | GTP binding | Interacting selectively and non-covalently with GTP, guanosine triphosphate. |
Transcript | Name | Description | Predicted domains | Domain count |
---|---|---|---|---|
– | Interferon-induced GTP-binding protein Mx [Medicago truncatula] gi|357519157|ref|XP_003629867.1| | 20 | ||
– | PREDICTED: dynamin-related protein 1E-like [Cicer arietinum] gi|502152578|ref|XP_004508991.1| | 16 | ||
– | PREDICTED: dynamin-2B-like [Glycine max] gi|356522123|ref|XP_003529699.1| | 22 | ||
– | PREDICTED: dynamin-related protein 1E-like isoform 1 [Glycine max] gi|356527252|ref|XP_003532226.1| | 22 | ||
– | PREDICTED: dynamin-related protein 5A-like [Cicer arietinum] gi|502155333|ref|XP_004510036.1| | 14 | ||
– | Dynamin homolog [Astragalus sinicus] gi|6625788|gb|AAF19398.1|AF203882_1 | 28 | ||
– | PREDICTED: dynamin-related protein 1E-like isoform 1 [Glycine max] gi|356520720|ref|XP_003529008.1| | 21 | ||
– | PREDICTED: dynamin-related protein 1E-like [Cicer arietinum] gi|502155644|ref|XP_004510142.1| | 23 | ||
– | PREDICTED: dynamin-2B-like [Glycine max] gi|356563206|ref|XP_003549855.1| | 30 | ||
– | PREDICTED: dynamin-like protein ARC5-like [Glycine max] gi|356524868|ref|XP_003531050.1| | 14 | ||
– | PREDICTED: dynamin-like protein ARC5-like [Glycine max] gi|356524868|ref|XP_003531050.1| | 13 | ||
– | PREDICTED: dynamin-related protein 3A-like [Glycine max] gi|356519473|ref|XP_003528397.1| | 28 | ||
– | PREDICTED: dynamin-related protein 4C-like [Cicer arietinum] gi|502140569|ref|XP_004504261.1| | 15 | ||
– | PREDICTED: dynamin-related protein 4C-like [Cicer arietinum] gi|502140569|ref|XP_004504261.1| | 12 | ||
– | PREDICTED: dynamin-related protein 5A-like [Cicer arietinum] gi|502139021|ref|XP_004503616.1| | 22 | ||
– | PREDICTED: dynamin-related protein 1C-like isoform X1 [Cicer arietinum] gi|502138270|ref|XP_004503345.1| | 23 | ||
– | PREDICTED: dynamin-related protein 3A-like [Glycine max] gi|356554800|ref|XP_003545730.1| | 15 | ||
– | Dynamin family protein; TAIR: AT1G60500.1 Dynamin related protein 4C; Swiss-Prot: sp|Q9ZP55|DRP4C_ARATH Dynamin-related protein 4C; TrEMBL-Plants: tr|G7L7C0|G7L7C0_MEDTR Dynamin 4C-like protein; Found in the gene: LotjaGi1g1v0191800 | 21 | ||
– | Dynamin, putative; TAIR: AT3G60190.1 DYNAMIN-like 1E; Swiss-Prot: sp|Q9FNX5|DRP1E_ARATH Dynamin-related protein 1E; TrEMBL-Plants: tr|I1KYV5|I1KYV5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0597700 | 23 | ||
– | Dynamin, putative; TAIR: AT3G60190.1 DYNAMIN-like 1E; Swiss-Prot: sp|Q9FNX5|DRP1E_ARATH Dynamin-related protein 1E; TrEMBL-Plants: tr|I1KYV5|I1KYV5_SOYBN Uncharacterized protein; Found in the gene: LotjaGi1g1v0597700 | 23 | ||
– | Dynamin, putative; TAIR: AT3G60190.1 DYNAMIN-like 1E; Swiss-Prot: sp|Q39821|SDLCA_SOYBN Dynamin-related protein 12A; TrEMBL-Plants: tr|I3SR93|I3SR93_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0720000_LC | 15 | ||
– | Dynamin, putative; TAIR: AT3G60190.1 DYNAMIN-like 1E; Swiss-Prot: sp|Q39821|SDLCA_SOYBN Dynamin-related protein 12A; TrEMBL-Plants: tr|I3SR93|I3SR93_LOTJA Uncharacterized protein; Found in the gene: LotjaGi1g1v0720000_LC | 15 | ||
– | Dynamin-like family protein; TAIR: AT5G42080.1 dynamin-like protein; Swiss-Prot: sp|Q39828|SDL5A_SOYBN Dynamin-related protein 5A; TrEMBL-Plants: tr|A0A151SCZ5|A0A151SCZ5_CAJCA Dynamin-related protein 5A; Found in the gene: LotjaGi2g1v0442100 | 23 | ||
– | Dynamin-like family protein; TAIR: AT5G42080.1 dynamin-like protein; Swiss-Prot: sp|Q39828|SDL5A_SOYBN Dynamin-related protein 5A; TrEMBL-Plants: tr|A0A0B2QVL7|A0A0B2QVL7_GLYSO Dynamin-related protein 5A; Found in the gene: LotjaGi2g1v0442100 | 21 | ||
– | Dynamin-like family protein; TAIR: AT5G42080.1 dynamin-like protein; Swiss-Prot: sp|Q39828|SDL5A_SOYBN Dynamin-related protein 5A; TrEMBL-Plants: tr|A0A0L9TH92|A0A0L9TH92_PHAAN Uncharacterized protein; Found in the gene: LotjaGi2g1v0442100 | 21 | ||
– | Dynamin-like family protein; TAIR: AT5G42080.1 dynamin-like protein; Swiss-Prot: sp|Q39828|SDL5A_SOYBN Dynamin-related protein 5A; TrEMBL-Plants: tr|A0A151SCZ5|A0A151SCZ5_CAJCA Dynamin-related protein 5A; Found in the gene: LotjaGi2g1v0442100 | 23 | ||
– | Dynamin family protein; TAIR: AT1G53140.1 Dynamin related protein 5A; Swiss-Prot: sp|F4HPR5|DRP5A_ARATH Dynamin-related protein 5A; TrEMBL-Plants: tr|A0A072U158|A0A072U158_MEDTR Dynamin 5A-like protein; Found in the gene: LotjaGi3g1v0047100 | 14 | ||
– | Dynamin homolog; TAIR: AT1G59610.1 dynamin-like 3; Swiss-Prot: sp|Q9LQ55|DRP2B_ARATH Dynamin-2B; TrEMBL-Plants: tr|Q9SDX4|Q9SDX4_ASTSI Dynamin homolog; Found in the gene: LotjaGi3g1v0054800 | 31 | ||
– | Dynamin homolog; TAIR: AT1G59610.1 dynamin-like 3; Swiss-Prot: sp|Q9LQ55|DRP2B_ARATH Dynamin-2B; TrEMBL-Plants: tr|I1LVI3|I1LVI3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0054800 | 18 | ||
– | Dynamin homolog; TAIR: AT1G59610.1 dynamin-like 3; Swiss-Prot: sp|Q9LQ55|DRP2B_ARATH Dynamin-2B; TrEMBL-Plants: tr|I1LVI3|I1LVI3_SOYBN Uncharacterized protein; Found in the gene: LotjaGi3g1v0054800 | 18 | ||
– | Dynamin, putative; TAIR: AT3G60190.1 DYNAMIN-like 1E; Swiss-Prot: sp|Q9FNX5|DRP1E_ARATH Dynamin-related protein 1E; TrEMBL-Plants: tr|A0A151SN43|A0A151SN43_CAJCA Dynamin-related protein 1E; Found in the gene: LotjaGi3g1v0073000 | 24 | ||
– | Dynamin, putative; TAIR: AT3G60190.1 DYNAMIN-like 1E; Swiss-Prot: sp|Q9FNX5|DRP1E_ARATH Dynamin-related protein 1E; TrEMBL-Plants: tr|A0A151SN43|A0A151SN43_CAJCA Dynamin-related protein 1E; Found in the gene: LotjaGi3g1v0073000 | 23 | ||
– | Dynamin, putative; TAIR: AT3G60190.1 DYNAMIN-like 1E; Swiss-Prot: sp|Q9FNX5|DRP1E_ARATH Dynamin-related protein 1E; TrEMBL-Plants: tr|A0A151SN43|A0A151SN43_CAJCA Dynamin-related protein 1E; Found in the gene: LotjaGi3g1v0073000 | 18 | ||
– | Dynamin, putative; TAIR: AT3G60190.1 DYNAMIN-like 1E; Swiss-Prot: sp|Q9FNX5|DRP1E_ARATH Dynamin-related protein 1E; TrEMBL-Plants: tr|A0A151SN43|A0A151SN43_CAJCA Dynamin-related protein 1E; Found in the gene: LotjaGi3g1v0073000 | 23 | ||
– | Dynamin, putative; TAIR: AT3G61760.1 DYNAMIN-like 1B; Swiss-Prot: sp|Q39828|SDL5A_SOYBN Dynamin-related protein 5A; TrEMBL-Plants: tr|A0A0S3SYT0|A0A0S3SYT0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0395300 | 23 | ||
– | Dynamin; TAIR: AT3G61760.1 DYNAMIN-like 1B; Swiss-Prot: sp|Q84XF3|DRP1B_ARATH Dynamin-related protein 1B; TrEMBL-Plants: tr|A0A0L9T6L3|A0A0L9T6L3_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0395300 | 18 | ||
– | Dynamin, putative; TAIR: AT3G61760.1 DYNAMIN-like 1B; Swiss-Prot: sp|Q39828|SDL5A_SOYBN Dynamin-related protein 5A; TrEMBL-Plants: tr|A0A0S3SYT0|A0A0S3SYT0_PHAAN Uncharacterized protein; Found in the gene: LotjaGi3g1v0395300 | 26 | ||
– | Dynamin family protein; TAIR: AT1G59610.1 dynamin-like 3; Swiss-Prot: sp|Q9LQ55|DRP2B_ARATH Dynamin-2B; TrEMBL-Plants: tr|I1MQT0|I1MQT0_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0001200 | 31 | ||
– | Dynamin family protein, putative, expressed; TAIR: AT3G19720.1 P-loop containing nucleoside triphosphate hydrolases superfamily protein; Swiss-Prot: sp|Q84N64|ARC5_ARATH Dynamin-like protein ARC5; TrEMBL-Plants: tr|A0A072UN67|A0A072UN67_MEDTR Dynamin-related protein 5B-2; Found in the gene: LotjaGi4g1v0032700 | 14 | ||
– | Dynamin, putative; TAIR: AT4G33650.1 dynamin-related protein 3A; Swiss-Prot: sp|Q8S944|DRP3A_ARATH Dynamin-related protein 3A; TrEMBL-Plants: tr|K7L2I2|K7L2I2_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0040300 | 26 | ||
– | Dynamin, putative; TAIR: AT3G60190.1 DYNAMIN-like 1E; Swiss-Prot: sp|Q9FNX5|DRP1E_ARATH Dynamin-related protein 1E; TrEMBL-Plants: tr|A0A151R3B5|A0A151R3B5_CAJCA Dynamin-related protein 1E; Found in the gene: LotjaGi4g1v0191000 | 24 | ||
– | Dynamin-like family protein; TAIR: AT5G42080.1 dynamin-like protein; Swiss-Prot: sp|Q39828|SDL5A_SOYBN Dynamin-related protein 5A; TrEMBL-Plants: tr|I1K693|I1K693_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0435900 | 23 | ||
– | Dynamin-like family protein; TAIR: AT5G42080.1 dynamin-like protein; Swiss-Prot: sp|Q39828|SDL5A_SOYBN Dynamin-related protein 5A; TrEMBL-Plants: tr|I1K693|I1K693_SOYBN Uncharacterized protein; Found in the gene: LotjaGi4g1v0435900 | 21 | ||
– | Dynamin-like family protein; TAIR: AT5G42080.1 dynamin-like protein; Swiss-Prot: sp|Q39828|SDL5A_SOYBN Dynamin-related protein 5A; TrEMBL-Plants: tr|A0A0B2Q5E1|A0A0B2Q5E1_GLYSO Dynamin-related protein 5A; Found in the gene: LotjaGi4g1v0435900 | 18 | ||
– | Dynamin; TAIR: AT1G14830.1 DYNAMIN-like 1C; Swiss-Prot: sp|Q8LF21|DRP1C_ARATH Dynamin-related protein 1C; TrEMBL-Plants: tr|G7LBF4|G7LBF4_MEDTR Dynamin-like protein 1E; Found in the gene: LotjaGi4g1v0457600 | 24 | ||
– | Dynamin; TAIR: AT1G14830.1 DYNAMIN-like 1C; Swiss-Prot: sp|Q8LF21|DRP1C_ARATH Dynamin-related protein 1C; TrEMBL-Plants: tr|G7LBF4|G7LBF4_MEDTR Dynamin-like protein 1E; Found in the gene: LotjaGi4g1v0457600 | 15 | ||
– | Dynamin, putative; TAIR: AT4G33650.1 dynamin-related protein 3A; Swiss-Prot: sp|Q8S944|DRP3A_ARATH Dynamin-related protein 3A; TrEMBL-Plants: tr|I1ME12|I1ME12_SOYBN Uncharacterized protein; Found in the gene: LotjaGi6g1v0348900 | 25 | ||
– | Dynamin, putative; TAIR: AT4G33650.1 dynamin-related protein 3A; Swiss-Prot: sp|Q8S944|DRP3A_ARATH Dynamin-related protein 3A; TrEMBL-Plants: tr|V7BTI1|V7BTI1_PHAVU Uncharacterized protein; Found in the gene: LotjaGi6g1v0348900 | 16 |
A list of co-occurring predicted domains within the L. japonicus gene space:
Predicted domain | Source | Observations | Saturation (%) |
---|---|---|---|
cd08771 | CDD | 1 | 2.08 |