Description

IPR031127 is a E3 ubiquitin ligase RBR family.

<p>This family of E3 ligases has a distinctive organisation of RING fingers called 'RING-betweenRING-RING' (RBR), characterised by two RING fingers with a cysteine-rich region called the 'in-between-RING' domain that separates them [[cite:PUB00033665], [cite:PUB00074865]]. The domains in the RBR E3 ligases have been further named as RING1-BRcat-Rcat according to their structure and function: the C-terminal Rcat (required-for-catalysis) domain is essential for catalytic activity, whereas the central BRcat (benign-catalytic) domain adopts the same fold as the Rcat, but lacks a catalytic cysteine residue and ubiquitination activity [[cite:PUB00074719]]. These ligases have a unique mechanism of elongating ubiquitin chains that distinguishes them from other E3 ligases [[cite:PUB00074717], [cite:PUB00074720]].</p> <p>On the basis of sequence conservation within the RBR segment, RBR proteins are assigned to 15 subfamilies (A-I, P, S, T, U, X, Z). There are two RBR proteins in the yeast Saccharomyces cerevisiae, six in Drosophila melanogaster, 10 in Caenorhabditis elegans, about 40 in Arabidopsis thaliana, around 23 in the zebrafish (Danio rerio), and about 15 in humans [[cite:PUB00074866]].</p>

This description is obtained from EB-eye REST.

Associated GO terms

GO predictions are based solely on the InterPro-to-GO mappings published by EMBL-EBI, which are in turn based on the mapping of predicted domains to the InterPro dataset. The InterPro-to-GO mapping was last updated on April 27, 2020, while the GO metadata was last updated on April 27, 2020.

Associated Lotus transcripts 55

Co-occuring domains 1

A list of co-occurring predicted domains within the L. japonicus gene space: